Inhibition of Type III CRISPR-Cas Immunity by an Archaeal Virus-Encoded Anti-CRISPR Protein

Yuvaraj Bhoobalan-Chitty; Thomas Baek Johansen; Nadia Di Cianni; Xu Peng

doi:10.1016/j.cell.2019.09.003

Inhibition of Type III CRISPR-Cas Immunity by an Archaeal Virus-Encoded Anti-CRISPR Protein

Yuvaraj Bhoobalan-Chitty, Thomas Baek Johansen, Nadia Di Cianni, Xu Peng^*

^*Corresponding author for this work

33 Citations (Scopus)

Abstract

Viruses infecting the archaeon Sulfolobus encode an inhibitor of the type III-B CRISPR-Cas system of their host, which specifically inhibits CRISPR-based targeting of viral middle and late genes.

Original language	English
Journal	Cell
Volume	179
Issue number	2
Pages (from-to)	448-458, e1-e11
ISSN	0092-8674
DOIs	https://doi.org/10.1016/j.cell.2019.09.003
Publication status	Published - 2019

Keywords

AcrIIIB
anti-CRISPR
cell dormancy
Cmr
Cmr2 (Cas10)
collateral RNA degradation
CRISPR-Cas type III accessory RNase
middle/late viral genes

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http://www.cell.com/article/S0092867419310098/pdf

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title = "Inhibition of Type III CRISPR-Cas Immunity by an Archaeal Virus-Encoded Anti-CRISPR Protein",

abstract = "Viruses infecting the archaeon Sulfolobus encode an inhibitor of the type III-B CRISPR-Cas system of their host, which specifically inhibits CRISPR-based targeting of viral middle and late genes.",

keywords = "AcrIIIB, anti-CRISPR, cell dormancy, Cmr, Cmr2 (Cas10), collateral RNA degradation, CRISPR-Cas type III accessory RNase, middle/late viral genes",

author = "Yuvaraj Bhoobalan-Chitty and Johansen, {Thomas Baek} and {Di Cianni}, Nadia and Xu Peng",

year = "2019",

doi = "10.1016/j.cell.2019.09.003",

language = "English",

volume = "179",

pages = "448--458, e1--e11",

journal = "Cell",

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T1 - Inhibition of Type III CRISPR-Cas Immunity by an Archaeal Virus-Encoded Anti-CRISPR Protein

AU - Bhoobalan-Chitty, Yuvaraj

AU - Johansen, Thomas Baek

AU - Di Cianni, Nadia

AU - Peng, Xu

PY - 2019

Y1 - 2019

N2 - Viruses infecting the archaeon Sulfolobus encode an inhibitor of the type III-B CRISPR-Cas system of their host, which specifically inhibits CRISPR-based targeting of viral middle and late genes.

AB - Viruses infecting the archaeon Sulfolobus encode an inhibitor of the type III-B CRISPR-Cas system of their host, which specifically inhibits CRISPR-based targeting of viral middle and late genes.

KW - AcrIIIB

KW - anti-CRISPR

KW - cell dormancy

KW - Cmr

KW - Cmr2 (Cas10)

KW - collateral RNA degradation

KW - CRISPR-Cas type III accessory RNase

KW - middle/late viral genes

U2 - 10.1016/j.cell.2019.09.003

DO - 10.1016/j.cell.2019.09.003

M3 - Journal article

C2 - 31564454

AN - SCOPUS:85072727639

SN - 0092-8674

VL - 179

SP - 448-458, e1-e11

JO - Cell

JF - Cell

IS - 2

ER -

Inhibition of Type III CRISPR-Cas Immunity by an Archaeal Virus-Encoded Anti-CRISPR Protein

Abstract

Keywords

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