Inhibition of molar eruption and root elongation in MT1-MMP-deficient mice

W Beertsen; K Holmbeck; A Niehof; P Bianco; K Chrysovergis; H Birkedal-Hansen; V Everts

Inhibition of molar eruption and root elongation in MT1-MMP-deficient mice

W Beertsen, K Holmbeck, A Niehof, P Bianco, K Chrysovergis, H Birkedal-Hansen, V Everts

11 Citations (Scopus)

Abstract

To study whether eruption of teeth and root growth require remodeling of collagen in the peridental tissues, we studied molar development in mice deficient in MT1-MMP, an enzyme essential for remodeling of soft tissue-hard tissue interfaces. The lower jaws of deficient mice and their wildtype littermates were subjected to stereologic analysis. It was shown that in deficient animals, eruption and root elongation were severely inhibited, signifying a role of the enzyme in these developmental processes.

Original language	English
Journal	Connective Tissue Research
Volume	44 Suppl 1
Pages (from-to)	298-9
Number of pages	2
ISSN	0300-8207
Publication status	Published - 2003

Keywords

Animals
Bone Remodeling/physiology
Calcification, Physiologic/physiology
Fibrillar Collagens/metabolism
Matrix Metalloproteinase 14
Matrix Metalloproteinases, Membrane-Associated
Metalloendopeptidases/deficiency
Mice
Mice, Knockout
Molar/enzymology
Periodontal Ligament/cytology
Tooth Eruption/physiology
Tooth Root/cytology

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title = "Inhibition of molar eruption and root elongation in MT1-MMP-deficient mice",

abstract = "To study whether eruption of teeth and root growth require remodeling of collagen in the peridental tissues, we studied molar development in mice deficient in MT1-MMP, an enzyme essential for remodeling of soft tissue-hard tissue interfaces. The lower jaws of deficient mice and their wildtype littermates were subjected to stereologic analysis. It was shown that in deficient animals, eruption and root elongation were severely inhibited, signifying a role of the enzyme in these developmental processes.",

keywords = "Animals, Bone Remodeling/physiology, Calcification, Physiologic/physiology, Fibrillar Collagens/metabolism, Matrix Metalloproteinase 14, Matrix Metalloproteinases, Membrane-Associated, Metalloendopeptidases/deficiency, Mice, Mice, Knockout, Molar/enzymology, Periodontal Ligament/cytology, Tooth Eruption/physiology, Tooth Root/cytology",

author = "W Beertsen and K Holmbeck and A Niehof and P Bianco and K Chrysovergis and H Birkedal-Hansen and V Everts",

year = "2003",

language = "English",

volume = "44 Suppl 1",

pages = "298--9",

journal = "Connective Tissue Research",

issn = "0300-8207",

publisher = "Taylor & Francis",

}

TY - JOUR

T1 - Inhibition of molar eruption and root elongation in MT1-MMP-deficient mice

AU - Beertsen, W

AU - Holmbeck, K

AU - Niehof, A

AU - Bianco, P

AU - Chrysovergis, K

AU - Birkedal-Hansen, H

AU - Everts, V

PY - 2003

Y1 - 2003

N2 - To study whether eruption of teeth and root growth require remodeling of collagen in the peridental tissues, we studied molar development in mice deficient in MT1-MMP, an enzyme essential for remodeling of soft tissue-hard tissue interfaces. The lower jaws of deficient mice and their wildtype littermates were subjected to stereologic analysis. It was shown that in deficient animals, eruption and root elongation were severely inhibited, signifying a role of the enzyme in these developmental processes.

AB - To study whether eruption of teeth and root growth require remodeling of collagen in the peridental tissues, we studied molar development in mice deficient in MT1-MMP, an enzyme essential for remodeling of soft tissue-hard tissue interfaces. The lower jaws of deficient mice and their wildtype littermates were subjected to stereologic analysis. It was shown that in deficient animals, eruption and root elongation were severely inhibited, signifying a role of the enzyme in these developmental processes.

KW - Animals

KW - Bone Remodeling/physiology

KW - Calcification, Physiologic/physiology

KW - Fibrillar Collagens/metabolism

KW - Matrix Metalloproteinase 14

KW - Matrix Metalloproteinases, Membrane-Associated

KW - Metalloendopeptidases/deficiency

KW - Mice

KW - Mice, Knockout

KW - Molar/enzymology

KW - Periodontal Ligament/cytology

KW - Tooth Eruption/physiology

KW - Tooth Root/cytology

M3 - Journal article

C2 - 12952212

SN - 0300-8207

VL - 44 Suppl 1

SP - 298

EP - 299

JO - Connective Tissue Research

JF - Connective Tissue Research

ER -

Inhibition of molar eruption and root elongation in MT1-MMP-deficient mice

Abstract

Keywords

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