Inhibition of Cu-amyloid-β by using bifunctional peptides with β-sheet breaker and chelator moieties

TY - JOUR

T1 - Inhibition of Cu-amyloid-β by using bifunctional peptides with β-sheet breaker and chelator moieties

AU - Jensen, Madeleine

AU - Canning, Anne

AU - Chiha, Sabri

AU - Bouquerel, Pierre

AU - Pedersen, Jeppe Trudslev

AU - Østergaard, Jesper

AU - Cuvillier, Olivier

AU - Sasaki, Isabelle

AU - Hureau, Christelle

AU - Faller, Peter

PY - 2012/4/16

Y1 - 2012/4/16

N2 - Breaking the mold: Inhibition of toxic amyloid-β (Aβ) aggregates and disruption of Cu-Aβ with subsequent redox-silencing of Cu have been considered promising strategies against Alzheimer's disease. The design and proof of concept of simple peptides containing a Cu-chelating/redox-silencing unit and an Aβ-aggregation inhibition unit (β-sheet breaker) is described (see scheme).

AB - Breaking the mold: Inhibition of toxic amyloid-β (Aβ) aggregates and disruption of Cu-Aβ with subsequent redox-silencing of Cu have been considered promising strategies against Alzheimer's disease. The design and proof of concept of simple peptides containing a Cu-chelating/redox-silencing unit and an Aβ-aggregation inhibition unit (β-sheet breaker) is described (see scheme).

U2 - 10.1002/chem.201103546

DO - 10.1002/chem.201103546

M3 - Journal article

C2 - 22422637

SN - 0947-6539

VL - 18

SP - 4836

EP - 4839

JO - Chemistry: A European Journal

JF - Chemistry: A European Journal

IS - 16

ER -