Influx of a choline analog to dog brain measured by positron emission tomography.

C Redies; M Diksic; B Collier; A Gjedde; C J Thompson; S Gauthier; W H Feindel

doi:10.1002/syn.890020407

Influx of a choline analog to dog brain measured by positron emission tomography.

C Redies, M Diksic, B Collier, A Gjedde, C J Thompson, S Gauthier, W H Feindel

9 Citations (Scopus)

Abstract

The influx of the 11C-labeled choline analog pyrrolidinocholine into tissue was measured in the brain of three dogs by positron emission tomography (PET). During the first 90 s after the intravenous bolus injection of the tracer, transfer of tracer from plasma to tissue was unidirectional. The influx constant for pyrrolidinocholine into intracranial tissue, Kin, was 0.017 ml/g/min (0.008 SD), and the initial volume of distribution, V0, was 0.08 ml/g (0.03 SD). The influx constant was at least five times larger than the value expected if simple diffusion were to account for tissue uptake. The method presented in this paper can be used to investigate the availability of plasma choline and its analogs to the living human brain and other tissue in degenerative diseases affecting the cholinergic system, and to provide in vivo information on a choline transport system.

Original language	English
Journal	Synapse
Volume	2
Issue number	4
Pages (from-to)	406-11
Number of pages	5
ISSN	0887-4476
DOIs	https://doi.org/10.1002/syn.890020407
Publication status	Published - 1988
Externally published	Yes

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10.1002/syn.890020407

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@article{2b1a1bb0b31511debc73000ea68e967b,

title = "Influx of a choline analog to dog brain measured by positron emission tomography.",

abstract = "The influx of the 11C-labeled choline analog pyrrolidinocholine into tissue was measured in the brain of three dogs by positron emission tomography (PET). During the first 90 s after the intravenous bolus injection of the tracer, transfer of tracer from plasma to tissue was unidirectional. The influx constant for pyrrolidinocholine into intracranial tissue, Kin, was 0.017 ml/g/min (0.008 SD), and the initial volume of distribution, V0, was 0.08 ml/g (0.03 SD). The influx constant was at least five times larger than the value expected if simple diffusion were to account for tissue uptake. The method presented in this paper can be used to investigate the availability of plasma choline and its analogs to the living human brain and other tissue in degenerative diseases affecting the cholinergic system, and to provide in vivo information on a choline transport system.",

author = "C Redies and M Diksic and B Collier and A Gjedde and Thompson, {C J} and S Gauthier and Feindel, {W H}",

year = "1988",

doi = "10.1002/syn.890020407",

language = "English",

volume = "2",

pages = "406--11",

journal = "Synapse",

issn = "0887-4476",

publisher = "Wiley",

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TY - JOUR

T1 - Influx of a choline analog to dog brain measured by positron emission tomography.

AU - Redies, C

AU - Diksic, M

AU - Collier, B

AU - Gjedde, A

AU - Thompson, C J

AU - Gauthier, S

AU - Feindel, W H

PY - 1988

Y1 - 1988

N2 - The influx of the 11C-labeled choline analog pyrrolidinocholine into tissue was measured in the brain of three dogs by positron emission tomography (PET). During the first 90 s after the intravenous bolus injection of the tracer, transfer of tracer from plasma to tissue was unidirectional. The influx constant for pyrrolidinocholine into intracranial tissue, Kin, was 0.017 ml/g/min (0.008 SD), and the initial volume of distribution, V0, was 0.08 ml/g (0.03 SD). The influx constant was at least five times larger than the value expected if simple diffusion were to account for tissue uptake. The method presented in this paper can be used to investigate the availability of plasma choline and its analogs to the living human brain and other tissue in degenerative diseases affecting the cholinergic system, and to provide in vivo information on a choline transport system.

AB - The influx of the 11C-labeled choline analog pyrrolidinocholine into tissue was measured in the brain of three dogs by positron emission tomography (PET). During the first 90 s after the intravenous bolus injection of the tracer, transfer of tracer from plasma to tissue was unidirectional. The influx constant for pyrrolidinocholine into intracranial tissue, Kin, was 0.017 ml/g/min (0.008 SD), and the initial volume of distribution, V0, was 0.08 ml/g (0.03 SD). The influx constant was at least five times larger than the value expected if simple diffusion were to account for tissue uptake. The method presented in this paper can be used to investigate the availability of plasma choline and its analogs to the living human brain and other tissue in degenerative diseases affecting the cholinergic system, and to provide in vivo information on a choline transport system.

U2 - 10.1002/syn.890020407

DO - 10.1002/syn.890020407

M3 - Journal article

C2 - 3263708

SN - 0887-4476

VL - 2

SP - 406

EP - 411

JO - Synapse

JF - Synapse

IS - 4

ER -

Influx of a choline analog to dog brain measured by positron emission tomography.

Abstract

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