Influenza A (H1N1) neuraminidase inhibitors from Vitis amurensis

Ngoc Anh Nguyen; Trong Tuan Dao; Bui Thanh Tung; Hwanwon Choi; Eunhee Kim; Junsoo Park; Seong Il Lim; Won Keun Oh

Influenza A (H1N1) neuraminidase inhibitors from Vitis amurensis

Ngoc Anh Nguyen, Trong Tuan Dao, Bui Thanh Tung, Hwanwon Choi, Eunhee Kim, Junsoo Park, Seong Il Lim, Won Keun Oh

35 Citations (Scopus)

Abstract

Recently, a novel H1N1 influenza A virus (H1N1/09 virus) was identified and considered a strong candidate for a novel influenza pandemic. As part of an ongoing anti-influenza screening programme on natural products, eight oligostilbenes were isolated as active principles from the methanol extract of Vitis amurensis. This manuscript reports the isolation, structural elucidation, and anti-viral activities of eight compounds on various neuraminidases from influenza A/PR/8/34 (H1N1), novel swine-origin influenza A (H1N1), and oseltamivir-resistant novel H1N1 (H274Y) expressed in 293T cells. The inhibition model of compounds 4, 6, and 7 which showed the strongest activity on the neuraminidases was examined. Detailed kinetic analysis indicated that they were all non-competitive. The synergistic effect of a combination of these non-competitive inhibitors with oseltamivir makes them a potential possibility for the control of influenza infections.

Original language	English
Journal	Food Chemistry
Volume	124
Issue number	2
Pages (from-to)	437-443
ISSN	0308-8146
Publication status	Published - 15 Jan 2011

Cite this

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title = "Influenza A (H1N1) neuraminidase inhibitors from Vitis amurensis",

abstract = "Recently, a novel H1N1 influenza A virus (H1N1/09 virus) was identified and considered a strong candidate for a novel influenza pandemic. As part of an ongoing anti-influenza screening programme on natural products, eight oligostilbenes were isolated as active principles from the methanol extract of Vitis amurensis. This manuscript reports the isolation, structural elucidation, and anti-viral activities of eight compounds on various neuraminidases from influenza A/PR/8/34 (H1N1), novel swine-origin influenza A (H1N1), and oseltamivir-resistant novel H1N1 (H274Y) expressed in 293T cells. The inhibition model of compounds 4, 6, and 7 which showed the strongest activity on the neuraminidases was examined. Detailed kinetic analysis indicated that they were all non-competitive. The synergistic effect of a combination of these non-competitive inhibitors with oseltamivir makes them a potential possibility for the control of influenza infections.",

author = "Nguyen, {Ngoc Anh} and Dao, {Trong Tuan} and Tung, {Bui Thanh} and Hwanwon Choi and Eunhee Kim and Junsoo Park and Lim, {Seong Il} and Oh, {Won Keun}",

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T1 - Influenza A (H1N1) neuraminidase inhibitors from Vitis amurensis

AU - Nguyen, Ngoc Anh

AU - Dao, Trong Tuan

AU - Tung, Bui Thanh

AU - Choi, Hwanwon

AU - Kim, Eunhee

AU - Park, Junsoo

AU - Lim, Seong Il

AU - Oh, Won Keun

PY - 2011/1/15

Y1 - 2011/1/15

N2 - Recently, a novel H1N1 influenza A virus (H1N1/09 virus) was identified and considered a strong candidate for a novel influenza pandemic. As part of an ongoing anti-influenza screening programme on natural products, eight oligostilbenes were isolated as active principles from the methanol extract of Vitis amurensis. This manuscript reports the isolation, structural elucidation, and anti-viral activities of eight compounds on various neuraminidases from influenza A/PR/8/34 (H1N1), novel swine-origin influenza A (H1N1), and oseltamivir-resistant novel H1N1 (H274Y) expressed in 293T cells. The inhibition model of compounds 4, 6, and 7 which showed the strongest activity on the neuraminidases was examined. Detailed kinetic analysis indicated that they were all non-competitive. The synergistic effect of a combination of these non-competitive inhibitors with oseltamivir makes them a potential possibility for the control of influenza infections.

AB - Recently, a novel H1N1 influenza A virus (H1N1/09 virus) was identified and considered a strong candidate for a novel influenza pandemic. As part of an ongoing anti-influenza screening programme on natural products, eight oligostilbenes were isolated as active principles from the methanol extract of Vitis amurensis. This manuscript reports the isolation, structural elucidation, and anti-viral activities of eight compounds on various neuraminidases from influenza A/PR/8/34 (H1N1), novel swine-origin influenza A (H1N1), and oseltamivir-resistant novel H1N1 (H274Y) expressed in 293T cells. The inhibition model of compounds 4, 6, and 7 which showed the strongest activity on the neuraminidases was examined. Detailed kinetic analysis indicated that they were all non-competitive. The synergistic effect of a combination of these non-competitive inhibitors with oseltamivir makes them a potential possibility for the control of influenza infections.

M3 - Journal article

SN - 0308-8146

VL - 124

SP - 437

EP - 443

JO - Food Chemistry

JF - Food Chemistry

IS - 2

ER -

Influenza A (H1N1) neuraminidase inhibitors from Vitis amurensis

Abstract

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