Influence of sympathectomy in humans on the rhythmicity of 6-sulphatoxymelatonin urinary excretion

Morten Møller; Ole Osgaard; Michael Grønbech-Jensen

doi:10.1016/j.mce.2006.03.023

Influence of sympathectomy in humans on the rhythmicity of 6-sulphatoxymelatonin urinary excretion

Morten Møller, Ole Osgaard, Michael Grønbech-Jensen

Department of Neuroscience

5 Citations (Scopus)

Abstract

The amount of 6-sulphatoxymelatonin, the chief metabolite of melatonin, in the urine was measured in nine patients, who were subjected to bilateral sympathectomy at the second thoracic ganglionic level for treatment of hyperhidrosis of the palms. All patients showed before surgery a normal 6-sulphatoxymelatonin excretion with a peak in the excretion during the night time. After the sympathectomy, the high night time excretion was clearly abolished in five patients but remained high in four patients. This indicates that the segmental locations of the preganglionic sympathetic perikarya in the spinal cord, stimulating the melatonin secretion in the pineal gland in humans, vary between individuals. An increase in daytime melatonin excretion was observed in the patients responding to the sympathectomy with an abolished 6-sulphatoxymelatonin rhythm. This increase could indicate that the final sympathetic neurons innervating the pineal gland might have a both stimulatory and inhibitory function.

Original language	English
Journal	Molecular and Cellular Endocrinology
Volume	252
Issue number	1-2
Pages (from-to)	40-5
Number of pages	5
ISSN	0303-7207
DOIs	https://doi.org/10.1016/j.mce.2006.03.023
Publication status	Published - 2006

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@article{7027369046d511de87b8000ea68e967b,

title = "Influence of sympathectomy in humans on the rhythmicity of 6-sulphatoxymelatonin urinary excretion",

abstract = "The amount of 6-sulphatoxymelatonin, the chief metabolite of melatonin, in the urine was measured in nine patients, who were subjected to bilateral sympathectomy at the second thoracic ganglionic level for treatment of hyperhidrosis of the palms. All patients showed before surgery a normal 6-sulphatoxymelatonin excretion with a peak in the excretion during the night time. After the sympathectomy, the high night time excretion was clearly abolished in five patients but remained high in four patients. This indicates that the segmental locations of the preganglionic sympathetic perikarya in the spinal cord, stimulating the melatonin secretion in the pineal gland in humans, vary between individuals. An increase in daytime melatonin excretion was observed in the patients responding to the sympathectomy with an abolished 6-sulphatoxymelatonin rhythm. This increase could indicate that the final sympathetic neurons innervating the pineal gland might have a both stimulatory and inhibitory function.",

author = "Morten M{\o}ller and Ole Osgaard and Michael Gr{\o}nbech-Jensen",

note = "Keywords: Adult; Circadian Rhythm; Female; Ganglia, Spinal; Humans; Hyperhidrosis; Male; Melatonin; Middle Aged; Sympathectomy",

year = "2006",

doi = "10.1016/j.mce.2006.03.023",

language = "English",

volume = "252",

pages = "40--5",

journal = "Molecular and Cellular Endocrinology",

issn = "0303-7207",

publisher = "Elsevier Ireland Ltd",

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TY - JOUR

T1 - Influence of sympathectomy in humans on the rhythmicity of 6-sulphatoxymelatonin urinary excretion

AU - Møller, Morten

AU - Osgaard, Ole

AU - Grønbech-Jensen, Michael

N1 - Keywords: Adult; Circadian Rhythm; Female; Ganglia, Spinal; Humans; Hyperhidrosis; Male; Melatonin; Middle Aged; Sympathectomy

PY - 2006

Y1 - 2006

N2 - The amount of 6-sulphatoxymelatonin, the chief metabolite of melatonin, in the urine was measured in nine patients, who were subjected to bilateral sympathectomy at the second thoracic ganglionic level for treatment of hyperhidrosis of the palms. All patients showed before surgery a normal 6-sulphatoxymelatonin excretion with a peak in the excretion during the night time. After the sympathectomy, the high night time excretion was clearly abolished in five patients but remained high in four patients. This indicates that the segmental locations of the preganglionic sympathetic perikarya in the spinal cord, stimulating the melatonin secretion in the pineal gland in humans, vary between individuals. An increase in daytime melatonin excretion was observed in the patients responding to the sympathectomy with an abolished 6-sulphatoxymelatonin rhythm. This increase could indicate that the final sympathetic neurons innervating the pineal gland might have a both stimulatory and inhibitory function.

AB - The amount of 6-sulphatoxymelatonin, the chief metabolite of melatonin, in the urine was measured in nine patients, who were subjected to bilateral sympathectomy at the second thoracic ganglionic level for treatment of hyperhidrosis of the palms. All patients showed before surgery a normal 6-sulphatoxymelatonin excretion with a peak in the excretion during the night time. After the sympathectomy, the high night time excretion was clearly abolished in five patients but remained high in four patients. This indicates that the segmental locations of the preganglionic sympathetic perikarya in the spinal cord, stimulating the melatonin secretion in the pineal gland in humans, vary between individuals. An increase in daytime melatonin excretion was observed in the patients responding to the sympathectomy with an abolished 6-sulphatoxymelatonin rhythm. This increase could indicate that the final sympathetic neurons innervating the pineal gland might have a both stimulatory and inhibitory function.

U2 - 10.1016/j.mce.2006.03.023

DO - 10.1016/j.mce.2006.03.023

M3 - Journal article

C2 - 16647807

SN - 0303-7207

VL - 252

SP - 40

EP - 45

JO - Molecular and Cellular Endocrinology

JF - Molecular and Cellular Endocrinology

IS - 1-2

ER -

Influence of sympathectomy in humans on the rhythmicity of 6-sulphatoxymelatonin urinary excretion

Abstract

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