Influence of oleic acid on self-assembled liquid crystalline nanostructures

TY - CHAP

T1 - Influence of oleic acid on self-assembled liquid crystalline nanostructures

AU - Yaghmur, Anan

AU - Azmi, Intan Diana Mat

PY - 2014/4/1

Y1 - 2014/4/1

N2 - Various studies in the literature suggested a link between the consumption of olive oil and different food products enriched with oleic acid (OA) and various positive health effects. The central focus of this research field is on learning and predicting how OA intake induces these health benefits. In recent years, there is a growing interest in understanding the biological role of this monounsaturated cis fatty acid in regulating cell membranes and its effect on biological processes. In this context, it is interesting to explore the effect of its incorporation on the model membrane characteristics and properties. These studies are considered as first steps towards a deeper understanding of the molecular mechanisms underlying OA beneficial health effects and their association with the biological membrane properties. This chapter summarizes recent studies conducted on the influence of OA and its counterparts (saturated and trans fatty acids) on model lipid membranes. In particular, the main focus is to present recent investigations on the structural characterization and also the potential applications of lipidic non-lamellar self-assembled nanostructures loaded with OA. These lyotropic liquid crystalline (LLC) phases and microemulsions are attractive as drug delivery systems. The most investigated LLC phases are the inverted-type hexagonal (H2) and the inverted-type bicontinuous cubic (V2) nanostructures. These unique inverted type self-assembled systems are compatible, digestible, and bioadhesive matrices that are able to co-exist under equilibrium conditions with excess water. They display nanostructures closely related to those observed in biological membranes and posess interesting characteristics such as the high interfacial area (specific interfacial area up to ~400 m2/g), the high solubilization capacities of drugs with different physicochemical properties (hydrophilic, amphiphilic, and hydrophobic molecules), and the potential of controlling drug release. In particular, there is an enormous interest in testing the possibility of utilizing these LLC phases for enhancing the solubilization of poorly water-soluble drugs, obtaining sustained drug release, and improving the in vivo performance of various drug substances. The scope of this chapter also covers recent studies that have attempted to shed light on the possible fragmentation of these inverted type self-assembled nanostructures for forming nanoparticlulate formulations attractive for food and pharmaceutical applications. These nanostructured aqueous dispersions (mainly cubosomes, hexosomes, and micellar cubosomes) in which the submicron-sized dispersed particles envelope distinctive well-defined self-assembled nanostructures can be utilized in different applications owing to their low viscosity as compared to the corresponding non-dispersed bulk liquid crystalline phases and their biological relevance.

AB - Various studies in the literature suggested a link between the consumption of olive oil and different food products enriched with oleic acid (OA) and various positive health effects. The central focus of this research field is on learning and predicting how OA intake induces these health benefits. In recent years, there is a growing interest in understanding the biological role of this monounsaturated cis fatty acid in regulating cell membranes and its effect on biological processes. In this context, it is interesting to explore the effect of its incorporation on the model membrane characteristics and properties. These studies are considered as first steps towards a deeper understanding of the molecular mechanisms underlying OA beneficial health effects and their association with the biological membrane properties. This chapter summarizes recent studies conducted on the influence of OA and its counterparts (saturated and trans fatty acids) on model lipid membranes. In particular, the main focus is to present recent investigations on the structural characterization and also the potential applications of lipidic non-lamellar self-assembled nanostructures loaded with OA. These lyotropic liquid crystalline (LLC) phases and microemulsions are attractive as drug delivery systems. The most investigated LLC phases are the inverted-type hexagonal (H2) and the inverted-type bicontinuous cubic (V2) nanostructures. These unique inverted type self-assembled systems are compatible, digestible, and bioadhesive matrices that are able to co-exist under equilibrium conditions with excess water. They display nanostructures closely related to those observed in biological membranes and posess interesting characteristics such as the high interfacial area (specific interfacial area up to ~400 m2/g), the high solubilization capacities of drugs with different physicochemical properties (hydrophilic, amphiphilic, and hydrophobic molecules), and the potential of controlling drug release. In particular, there is an enormous interest in testing the possibility of utilizing these LLC phases for enhancing the solubilization of poorly water-soluble drugs, obtaining sustained drug release, and improving the in vivo performance of various drug substances. The scope of this chapter also covers recent studies that have attempted to shed light on the possible fragmentation of these inverted type self-assembled nanostructures for forming nanoparticlulate formulations attractive for food and pharmaceutical applications. These nanostructured aqueous dispersions (mainly cubosomes, hexosomes, and micellar cubosomes) in which the submicron-sized dispersed particles envelope distinctive well-defined self-assembled nanostructures can be utilized in different applications owing to their low viscosity as compared to the corresponding non-dispersed bulk liquid crystalline phases and their biological relevance.

M3 - Book chapter

SN - 978-1-63117-576-3

SP - 9

EP - 34

BT - Oleic Acid

A2 - Whelan, Lynette

PB - Nova Science Publishers

CY - New York

ER -