Influence of nanoparticles of platinum on chicken embryo development and brain morphology

Marta  Prasek; Ewa Saworz; Slawomir Jaworski; Marta Grodzik; Teresa Ostaszewska; Maciej Kamaszewski; Mateusz Wierzbicki; André Chwalibog

doi:10.1186/1556-276X-8-251

Influence of nanoparticles of platinum on chicken embryo development and brain morphology

Marta Prasek, Ewa Saworz, Slawomir Jaworski, Marta Grodzik, Teresa Ostaszewska, Maciej Kamaszewski, Mateusz Wierzbicki, André Chwalibog

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Abstract

Platinum nanoparticles (NP-Pt) are noble metal nanoparticles with unique physiochemical properties that have recently elicited much interest in medical research. However, we still know little about their toxicity and influence on general health. We investigated effects of NP-Pt on the growth and development of the chicken embryo model with emphasis on brain tissue micro-and ultrastructure. The embryos were administered solutions of NP-Pt injected in ovo at concentrations from 1 to 20 μg/ml. The results demonstrate that NP-Pt did not affect the growth and development of the embryos; however, they induced apoptosis and decreased the number of proliferating cells in the brain tissue. These preliminary results indicate that properties of NP-Pt might be utilized in brain cancer therapy, but potential toxic side effects must be elucidated in extensive follow-up research.

Original language	English
Article number	251
Journal	Nanoscale Research Letters
Volume	8
Number of pages	9
ISSN	1931-7573
DOIs	https://doi.org/10.1186/1556-276X-8-251
Publication status	Published - 2013

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title = "Influence of nanoparticles of platinum on chicken embryo development and brain morphology",

abstract = "Platinum nanoparticles (NP-Pt) are noble metal nanoparticles with unique physiochemical properties that have recently elicited much interest in medical research. However, we still know little about their toxicity and influence on general health. We investigated effects of NP-Pt on the growth and development of the chicken embryo model with emphasis on brain tissue micro-and ultrastructure. The embryos were administered solutions of NP-Pt injected in ovo at concentrations from 1 to 20 μg/ml. The results demonstrate that NP-Pt did not affect the growth and development of the embryos; however, they induced apoptosis and decreased the number of proliferating cells in the brain tissue. These preliminary results indicate that properties of NP-Pt might be utilized in brain cancer therapy, but potential toxic side effects must be elucidated in extensive follow-up research.",

author = "Marta Prasek and Ewa Saworz and Slawomir Jaworski and Marta Grodzik and Teresa Ostaszewska and Maciej Kamaszewski and Mateusz Wierzbicki and Andr{\'e} Chwalibog",

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doi = "10.1186/1556-276X-8-251",

language = "English",

volume = "8",

journal = "Nanoscale Research Letters",

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T1 - Influence of nanoparticles of platinum on chicken embryo development and brain morphology

AU - Prasek, Marta

AU - Saworz, Ewa

AU - Jaworski, Slawomir

AU - Grodzik, Marta

AU - Ostaszewska, Teresa

AU - Kamaszewski, Maciej

AU - Wierzbicki, Mateusz

AU - Chwalibog, André

PY - 2013

Y1 - 2013

N2 - Platinum nanoparticles (NP-Pt) are noble metal nanoparticles with unique physiochemical properties that have recently elicited much interest in medical research. However, we still know little about their toxicity and influence on general health. We investigated effects of NP-Pt on the growth and development of the chicken embryo model with emphasis on brain tissue micro-and ultrastructure. The embryos were administered solutions of NP-Pt injected in ovo at concentrations from 1 to 20 μg/ml. The results demonstrate that NP-Pt did not affect the growth and development of the embryos; however, they induced apoptosis and decreased the number of proliferating cells in the brain tissue. These preliminary results indicate that properties of NP-Pt might be utilized in brain cancer therapy, but potential toxic side effects must be elucidated in extensive follow-up research.

AB - Platinum nanoparticles (NP-Pt) are noble metal nanoparticles with unique physiochemical properties that have recently elicited much interest in medical research. However, we still know little about their toxicity and influence on general health. We investigated effects of NP-Pt on the growth and development of the chicken embryo model with emphasis on brain tissue micro-and ultrastructure. The embryos were administered solutions of NP-Pt injected in ovo at concentrations from 1 to 20 μg/ml. The results demonstrate that NP-Pt did not affect the growth and development of the embryos; however, they induced apoptosis and decreased the number of proliferating cells in the brain tissue. These preliminary results indicate that properties of NP-Pt might be utilized in brain cancer therapy, but potential toxic side effects must be elucidated in extensive follow-up research.

U2 - 10.1186/1556-276X-8-251

DO - 10.1186/1556-276X-8-251

M3 - Journal article

C2 - 23705751

SN - 1931-7573

VL - 8

JO - Nanoscale Research Letters

JF - Nanoscale Research Letters

M1 - 251

ER -

Influence of nanoparticles of platinum on chicken embryo development and brain morphology

Abstract

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