Influence of metabolic indicators, smoking, alcohol and socioeconomic position on mortality after breast cancer

Signe Benzon Larsen; Niels Kroman; Else Helene Ibfelt; Jane Christensen; Anne Tjønneland; Susanne Oksbjerg Dalton

doi:10.3109/0284186X.2014.998774

Influence of metabolic indicators, smoking, alcohol and socioeconomic position on mortality after breast cancer

Signe Benzon Larsen, Niels Kroman, Else Helene Ibfelt, Jane Christensen, Anne Tjønneland, Susanne Oksbjerg Dalton

Department of Clinical Medicine

19 Citations (Scopus)

Abstract

BACKGROUND: Factors differently distributed among social groups like obesity, metabolic syndrome, diabetes, smoking, and alcohol intake predict survival after breast cancer diagnosis and therefore might mediate part of the observed social inequality in survival.

MATERIAL AND METHODS: We conducted a cohort study among 1250 postmenopausal breast cancer patients identified among 29 875 women in the Danish Diet, Cancer and Health Study. Participants completed questionnaires and anthropometric measurements were made at enrollment. Information on survival, socioeconomic position, and comorbidity was obtained by linkage to national Danish registries. Clinical information was obtained from the nationwide Danish Breast Cancer Database. Selected information was obtained from hospital records at time of diagnosis. All analyses were based on Cox proportional hazard models, using death from all causes as outcome.

RESULTS: Median follow-up was 9.6 years [interquartile range (IQR), 2.2-17.0 years]. The hazard ratio (HR) for death from all causes increased with lower education (p for trend, 0.01). Adjustment for disease-related prognostic factors, comorbidity and metabolic indicators measured as BMI, waist circumference and diabetes, and smoking and alcohol affected but did not explain the social gradient.

CONCLUSION: The findings indicate that these factors explain some but not all the social inequality in survival after breast cancer and that improvement of lifestyle to some extent would improve survival among women with low socioeconomic position.

Original language	English
Journal	Acta Oncologica
Volume	54
Issue number	5
Pages (from-to)	780-8
Number of pages	9
ISSN	0284-186X
DOIs	https://doi.org/10.3109/0284186X.2014.998774
Publication status	Published - 1 May 2015

Keywords

Aged
Alcohol Drinking
Body Mass Index
Breast Neoplasms
Cause of Death
Cohort Studies
Comorbidity
Denmark
Diabetes Mellitus, Type 2
Educational Status
Female
Humans
Life Style
Metabolic Syndrome X
Middle Aged
Obesity
Proportional Hazards Models
Smoking
Socioeconomic Factors
Waist Circumference

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3109/0284186X.2014.998774

Cite this

@article{12f3b8e2ea51454e8c9fbdcc4a7ea61c,

title = "Influence of metabolic indicators, smoking, alcohol and socioeconomic position on mortality after breast cancer",

abstract = "BACKGROUND: Factors differently distributed among social groups like obesity, metabolic syndrome, diabetes, smoking, and alcohol intake predict survival after breast cancer diagnosis and therefore might mediate part of the observed social inequality in survival.MATERIAL AND METHODS: We conducted a cohort study among 1250 postmenopausal breast cancer patients identified among 29 875 women in the Danish Diet, Cancer and Health Study. Participants completed questionnaires and anthropometric measurements were made at enrollment. Information on survival, socioeconomic position, and comorbidity was obtained by linkage to national Danish registries. Clinical information was obtained from the nationwide Danish Breast Cancer Database. Selected information was obtained from hospital records at time of diagnosis. All analyses were based on Cox proportional hazard models, using death from all causes as outcome.RESULTS: Median follow-up was 9.6 years [interquartile range (IQR), 2.2-17.0 years]. The hazard ratio (HR) for death from all causes increased with lower education (p for trend, 0.01). Adjustment for disease-related prognostic factors, comorbidity and metabolic indicators measured as BMI, waist circumference and diabetes, and smoking and alcohol affected but did not explain the social gradient.CONCLUSION: The findings indicate that these factors explain some but not all the social inequality in survival after breast cancer and that improvement of lifestyle to some extent would improve survival among women with low socioeconomic position.",

keywords = "Aged, Alcohol Drinking, Body Mass Index, Breast Neoplasms, Cause of Death, Cohort Studies, Comorbidity, Denmark, Diabetes Mellitus, Type 2, Educational Status, Female, Humans, Life Style, Metabolic Syndrome X, Middle Aged, Obesity, Proportional Hazards Models, Smoking, Socioeconomic Factors, Waist Circumference",

author = "Larsen, {Signe Benzon} and Niels Kroman and Ibfelt, {Else Helene} and Jane Christensen and Anne Tj{\o}nneland and Dalton, {Susanne Oksbjerg}",

year = "2015",

month = may,

day = "1",

doi = "10.3109/0284186X.2014.998774",

language = "English",

volume = "54",

pages = "780--8",

journal = "Acta Oncologica",

issn = "0284-186X",

publisher = "Taylor & Francis",

number = "5",

}

TY - JOUR

T1 - Influence of metabolic indicators, smoking, alcohol and socioeconomic position on mortality after breast cancer

AU - Larsen, Signe Benzon

AU - Kroman, Niels

AU - Ibfelt, Else Helene

AU - Christensen, Jane

AU - Tjønneland, Anne

AU - Dalton, Susanne Oksbjerg

PY - 2015/5/1

Y1 - 2015/5/1

N2 - BACKGROUND: Factors differently distributed among social groups like obesity, metabolic syndrome, diabetes, smoking, and alcohol intake predict survival after breast cancer diagnosis and therefore might mediate part of the observed social inequality in survival.MATERIAL AND METHODS: We conducted a cohort study among 1250 postmenopausal breast cancer patients identified among 29 875 women in the Danish Diet, Cancer and Health Study. Participants completed questionnaires and anthropometric measurements were made at enrollment. Information on survival, socioeconomic position, and comorbidity was obtained by linkage to national Danish registries. Clinical information was obtained from the nationwide Danish Breast Cancer Database. Selected information was obtained from hospital records at time of diagnosis. All analyses were based on Cox proportional hazard models, using death from all causes as outcome.RESULTS: Median follow-up was 9.6 years [interquartile range (IQR), 2.2-17.0 years]. The hazard ratio (HR) for death from all causes increased with lower education (p for trend, 0.01). Adjustment for disease-related prognostic factors, comorbidity and metabolic indicators measured as BMI, waist circumference and diabetes, and smoking and alcohol affected but did not explain the social gradient.CONCLUSION: The findings indicate that these factors explain some but not all the social inequality in survival after breast cancer and that improvement of lifestyle to some extent would improve survival among women with low socioeconomic position.

AB - BACKGROUND: Factors differently distributed among social groups like obesity, metabolic syndrome, diabetes, smoking, and alcohol intake predict survival after breast cancer diagnosis and therefore might mediate part of the observed social inequality in survival.MATERIAL AND METHODS: We conducted a cohort study among 1250 postmenopausal breast cancer patients identified among 29 875 women in the Danish Diet, Cancer and Health Study. Participants completed questionnaires and anthropometric measurements were made at enrollment. Information on survival, socioeconomic position, and comorbidity was obtained by linkage to national Danish registries. Clinical information was obtained from the nationwide Danish Breast Cancer Database. Selected information was obtained from hospital records at time of diagnosis. All analyses were based on Cox proportional hazard models, using death from all causes as outcome.RESULTS: Median follow-up was 9.6 years [interquartile range (IQR), 2.2-17.0 years]. The hazard ratio (HR) for death from all causes increased with lower education (p for trend, 0.01). Adjustment for disease-related prognostic factors, comorbidity and metabolic indicators measured as BMI, waist circumference and diabetes, and smoking and alcohol affected but did not explain the social gradient.CONCLUSION: The findings indicate that these factors explain some but not all the social inequality in survival after breast cancer and that improvement of lifestyle to some extent would improve survival among women with low socioeconomic position.

KW - Aged

KW - Alcohol Drinking

KW - Body Mass Index

KW - Breast Neoplasms

KW - Cause of Death

KW - Cohort Studies

KW - Comorbidity

KW - Denmark

KW - Diabetes Mellitus, Type 2

KW - Educational Status

KW - Female

KW - Humans

KW - Life Style

KW - Metabolic Syndrome X

KW - Middle Aged

KW - Obesity

KW - Proportional Hazards Models

KW - Smoking

KW - Socioeconomic Factors

KW - Waist Circumference

U2 - 10.3109/0284186X.2014.998774

DO - 10.3109/0284186X.2014.998774

M3 - Journal article

C2 - 25761087

SN - 0284-186X

VL - 54

SP - 780

EP - 788

JO - Acta Oncologica

JF - Acta Oncologica

IS - 5

ER -

Influence of metabolic indicators, smoking, alcohol and socioeconomic position on mortality after breast cancer

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this