Influence of disease process and duration on acute phase proteins in serum and peritoneal fluid of horses with colic

Tina Pihl; E. Scheepers; M. Sanz; A. Goddard; P. Page; Nils Toft; Pia Haubro Andersen; Stine Jacobsen

doi:10.1111/jvim.12542

Influence of disease process and duration on acute phase proteins in serum and peritoneal fluid of horses with colic

Tina Pihl, E. Scheepers, M. Sanz, A. Goddard, P. Page, Nils Toft, Pia Haubro Andersen, Stine Jacobsen

20 Citations (Scopus)

131 Downloads (Pure)

Abstract

Background: The acute phase proteins (APP) serum amyloid A (SAA), haptoglobin, and fibrinogen are valuable blood biomarkers in equine inflammatory diseases, but knowledge of factors influencing their concentrations in blood and peritoneal fluid (PF) of horses with colic is needed. Objectives: The objective of this study was to investigate the influence of demographics (age, sex, breed), disease process (simple obstruction, strangulating obstruction, inflammatory), disease location, disease duration, hypovolemia, and admission hospital on concentrations of APP, lactate and white blood cell counts (WBC) in horses with colic admitted to 2 referral hospitals. Animals: The study included 367 horses with colic admitted at 2 referral hospitals. Methods: Prospective multicenter observational study of clinical data, as well as blood and PF biomarkers. Associations between biomarker concentrations and clinical variables were analyzed using multivariate linear regression analysis. Results: Increasing pre-admission duration of colic was associated with increased concentrations of APP in blood and PF. Blood concentrations of SAA and fibrinogen were associated with disease process (inflammatory, strangulations, simple obstructions) in more colic duration groups (5-12 and >24 hours) than any of the other biomarkers. No relevant associations between demographic factors, hospital, or hydration status and the measured biomarkers were found. Conclusions and Clinical Importance: In horses with colic, concentrations of APP are associated mainly with disease process and duration of colic and may thus be used for assessment of disease independently of demographic or geographic factors. Serum amyloid A may be a diagnostic marker for use in colic differential diagnosis, but further evaluation is needed.

Original language	English
Journal	Journal of Veterinary Internal Medicine
Volume	29
Issue number	2
Pages (from-to)	651-658
Number of pages	8
ISSN	0891-6640
DOIs	https://doi.org/10.1111/jvim.12542
Publication status	Published - 1 Mar 2015

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Cite this

@article{ebabaf494d1b450aa41d58f9cc835228,

title = "Influence of disease process and duration on acute phase proteins in serum and peritoneal fluid of horses with colic",

abstract = "Background: The acute phase proteins (APP) serum amyloid A (SAA), haptoglobin, and fibrinogen are valuable blood biomarkers in equine inflammatory diseases, but knowledge of factors influencing their concentrations in blood and peritoneal fluid (PF) of horses with colic is needed. Objectives: The objective of this study was to investigate the influence of demographics (age, sex, breed), disease process (simple obstruction, strangulating obstruction, inflammatory), disease location, disease duration, hypovolemia, and admission hospital on concentrations of APP, lactate and white blood cell counts (WBC) in horses with colic admitted to 2 referral hospitals. Animals: The study included 367 horses with colic admitted at 2 referral hospitals. Methods: Prospective multicenter observational study of clinical data, as well as blood and PF biomarkers. Associations between biomarker concentrations and clinical variables were analyzed using multivariate linear regression analysis. Results: Increasing pre-admission duration of colic was associated with increased concentrations of APP in blood and PF. Blood concentrations of SAA and fibrinogen were associated with disease process (inflammatory, strangulations, simple obstructions) in more colic duration groups (5-12 and >24 hours) than any of the other biomarkers. No relevant associations between demographic factors, hospital, or hydration status and the measured biomarkers were found. Conclusions and Clinical Importance: In horses with colic, concentrations of APP are associated mainly with disease process and duration of colic and may thus be used for assessment of disease independently of demographic or geographic factors. Serum amyloid A may be a diagnostic marker for use in colic differential diagnosis, but further evaluation is needed.",

author = "Tina Pihl and E. Scheepers and M. Sanz and A. Goddard and P. Page and Nils Toft and Andersen, {Pia Haubro} and Stine Jacobsen",

year = "2015",

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language = "English",

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T1 - Influence of disease process and duration on acute phase proteins in serum and peritoneal fluid of horses with colic

AU - Pihl, Tina

AU - Scheepers, E.

AU - Sanz, M.

AU - Goddard, A.

AU - Page, P.

AU - Toft, Nils

AU - Andersen, Pia Haubro

AU - Jacobsen, Stine

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Background: The acute phase proteins (APP) serum amyloid A (SAA), haptoglobin, and fibrinogen are valuable blood biomarkers in equine inflammatory diseases, but knowledge of factors influencing their concentrations in blood and peritoneal fluid (PF) of horses with colic is needed. Objectives: The objective of this study was to investigate the influence of demographics (age, sex, breed), disease process (simple obstruction, strangulating obstruction, inflammatory), disease location, disease duration, hypovolemia, and admission hospital on concentrations of APP, lactate and white blood cell counts (WBC) in horses with colic admitted to 2 referral hospitals. Animals: The study included 367 horses with colic admitted at 2 referral hospitals. Methods: Prospective multicenter observational study of clinical data, as well as blood and PF biomarkers. Associations between biomarker concentrations and clinical variables were analyzed using multivariate linear regression analysis. Results: Increasing pre-admission duration of colic was associated with increased concentrations of APP in blood and PF. Blood concentrations of SAA and fibrinogen were associated with disease process (inflammatory, strangulations, simple obstructions) in more colic duration groups (5-12 and >24 hours) than any of the other biomarkers. No relevant associations between demographic factors, hospital, or hydration status and the measured biomarkers were found. Conclusions and Clinical Importance: In horses with colic, concentrations of APP are associated mainly with disease process and duration of colic and may thus be used for assessment of disease independently of demographic or geographic factors. Serum amyloid A may be a diagnostic marker for use in colic differential diagnosis, but further evaluation is needed.

AB - Background: The acute phase proteins (APP) serum amyloid A (SAA), haptoglobin, and fibrinogen are valuable blood biomarkers in equine inflammatory diseases, but knowledge of factors influencing their concentrations in blood and peritoneal fluid (PF) of horses with colic is needed. Objectives: The objective of this study was to investigate the influence of demographics (age, sex, breed), disease process (simple obstruction, strangulating obstruction, inflammatory), disease location, disease duration, hypovolemia, and admission hospital on concentrations of APP, lactate and white blood cell counts (WBC) in horses with colic admitted to 2 referral hospitals. Animals: The study included 367 horses with colic admitted at 2 referral hospitals. Methods: Prospective multicenter observational study of clinical data, as well as blood and PF biomarkers. Associations between biomarker concentrations and clinical variables were analyzed using multivariate linear regression analysis. Results: Increasing pre-admission duration of colic was associated with increased concentrations of APP in blood and PF. Blood concentrations of SAA and fibrinogen were associated with disease process (inflammatory, strangulations, simple obstructions) in more colic duration groups (5-12 and >24 hours) than any of the other biomarkers. No relevant associations between demographic factors, hospital, or hydration status and the measured biomarkers were found. Conclusions and Clinical Importance: In horses with colic, concentrations of APP are associated mainly with disease process and duration of colic and may thus be used for assessment of disease independently of demographic or geographic factors. Serum amyloid A may be a diagnostic marker for use in colic differential diagnosis, but further evaluation is needed.

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DO - 10.1111/jvim.12542

M3 - Journal article

C2 - 25644457

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JO - Journal of Veterinary Internal Medicine

JF - Journal of Veterinary Internal Medicine

IS - 2

ER -

Influence of disease process and duration on acute phase proteins in serum and peritoneal fluid of horses with colic

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