Influence of dietary protein intake and glycemic index on the association between TCF7L2 HapA and weight gain

Eva Fisher; Karina Meidtner; Lars Henrik Ängquist; Claus Holst; Rikke Dalgaard Hansen; Jytte Halkjær; Giovanna Masala; Jane Nautrup Ostergaard; Kim Overvad; Domenico Palli; Karani S Vimaleswaran; Anne Tjønneland; Daphne L van der A; Nicholas J Wareham; Thorkild Ia Sørensen; Ruth Jf Loos; Heiner Boeing

doi:10.3945/ajcn.111.014670

Influence of dietary protein intake and glycemic index on the association between TCF7L2 HapA and weight gain

Eva Fisher, Karina Meidtner, Lars Henrik Ängquist, Claus Holst, Rikke Dalgaard Hansen, Jytte Halkjær, Giovanna Masala, Jane Nautrup Ostergaard, Kim Overvad, Domenico Palli, Karani S Vimaleswaran, Anne Tjønneland, Daphne L van der A, Nicholas J Wareham, Thorkild Ia Sørensen, Ruth Jf Loos, Heiner Boeing

15 Citations (Scopus)

Abstract

Background: Genetic polymorphisms of transcription factor 7-like 2 (TCF7L2) have been associated with type 2 diabetes and BMI. Objective: The objective was to investigate whether TCF7L2 HapA is associated with weight development and whether such an association is modulated by protein intake or by the glycemic index (GI). Design: The investigation was based on prospective data from 5 cohort studies nested within the European Prospective Investigation into Cancer and Nutrition.Weight change was followed up for a mean (±SD) of 6.8 ± 2.5 y. TCF7L2 rs7903146 and rs10885406 were successfully genotyped in 11,069 individuals and used to derive HapA. Multiple logistic and linear regression analysis was applied to test for the main effect of HapA and its interaction with dietary protein or GI. Analyses from the cohorts were combined by random-effects meta-analysis. Results: HapA was associated neither with baseline BMI (0.03 ± 0.07 BMI units per allele; P = 0.6) nor with annual weight change (8.8 ± 11.7 g/y per allele; P = 0.5). However, a previously shown positive association between intake of protein, particularly of animal origin, and subsequent weight change in this population proved to be attenuated by TCF7L2 HapA (P-interaction = 0.01). We showed that weight gain becomes independent of protein intake with an increasing number of HapA alleles. Substitution of protein with either fat or carbohydrates showed the same effects. No interaction with GI was observed. Conclusion: TCF7L2 HapA attenuates the positive association between animal protein intake and long-term body weight change in middle-aged Europeans but does not interact with the GI of the diet.

Original language	English
Journal	American Journal of Clinical Nutrition
Volume	95
Issue number	6
Pages (from-to)	1468-76
Number of pages	9
ISSN	0002-9165
DOIs	https://doi.org/10.3945/ajcn.111.014670
Publication status	Published - 1 Jun 2012

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Fisher, E., Meidtner, K., Ängquist, L. H., Holst, C., Hansen, R. D., Halkjær, J., Masala, G., Ostergaard, J. N., Overvad, K., Palli, D., Vimaleswaran, K. S., Tjønneland, A., van der A, D. L., Wareham, N. J., Sørensen, T. I., Loos, R. J., & Boeing, H. (2012). Influence of dietary protein intake and glycemic index on the association between TCF7L2 HapA and weight gain. American Journal of Clinical Nutrition, 95(6), 1468-76. https://doi.org/10.3945/ajcn.111.014670

Fisher, E, Meidtner, K, Ängquist, LH, Holst, C, Hansen, RD, Halkjær, J, Masala, G, Ostergaard, JN, Overvad, K, Palli, D, Vimaleswaran, KS, Tjønneland, A, van der A, DL, Wareham, NJ, Sørensen, TI, Loos, RJ & Boeing, H 2012, 'Influence of dietary protein intake and glycemic index on the association between TCF7L2 HapA and weight gain', American Journal of Clinical Nutrition, vol. 95, no. 6, pp. 1468-76. https://doi.org/10.3945/ajcn.111.014670

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title = "Influence of dietary protein intake and glycemic index on the association between TCF7L2 HapA and weight gain",

abstract = "Background: Genetic polymorphisms of transcription factor 7-like 2 (TCF7L2) have been associated with type 2 diabetes and BMI. Objective: The objective was to investigate whether TCF7L2 HapA is associated with weight development and whether such an association is modulated by protein intake or by the glycemic index (GI). Design: The investigation was based on prospective data from 5 cohort studies nested within the European Prospective Investigation into Cancer and Nutrition.Weight change was followed up for a mean (±SD) of 6.8 ± 2.5 y. TCF7L2 rs7903146 and rs10885406 were successfully genotyped in 11,069 individuals and used to derive HapA. Multiple logistic and linear regression analysis was applied to test for the main effect of HapA and its interaction with dietary protein or GI. Analyses from the cohorts were combined by random-effects meta-analysis. Results: HapA was associated neither with baseline BMI (0.03 ± 0.07 BMI units per allele; P = 0.6) nor with annual weight change (8.8 ± 11.7 g/y per allele; P = 0.5). However, a previously shown positive association between intake of protein, particularly of animal origin, and subsequent weight change in this population proved to be attenuated by TCF7L2 HapA (P-interaction = 0.01). We showed that weight gain becomes independent of protein intake with an increasing number of HapA alleles. Substitution of protein with either fat or carbohydrates showed the same effects. No interaction with GI was observed. Conclusion: TCF7L2 HapA attenuates the positive association between animal protein intake and long-term body weight change in middle-aged Europeans but does not interact with the GI of the diet.",

author = "Eva Fisher and Karina Meidtner and {\"A}ngquist, {Lars Henrik} and Claus Holst and Hansen, {Rikke Dalgaard} and Jytte Halkj{\ae}r and Giovanna Masala and Ostergaard, {Jane Nautrup} and Kim Overvad and Domenico Palli and Vimaleswaran, {Karani S} and Anne Tj{\o}nneland and {van der A}, {Daphne L} and Wareham, {Nicholas J} and S{\o}rensen, {Thorkild Ia} and Loos, {Ruth Jf} and Heiner Boeing",

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TY - JOUR

T1 - Influence of dietary protein intake and glycemic index on the association between TCF7L2 HapA and weight gain

AU - Fisher, Eva

AU - Meidtner, Karina

AU - Ängquist, Lars Henrik

AU - Holst, Claus

AU - Hansen, Rikke Dalgaard

AU - Halkjær, Jytte

AU - Masala, Giovanna

AU - Ostergaard, Jane Nautrup

AU - Overvad, Kim

AU - Palli, Domenico

AU - Vimaleswaran, Karani S

AU - Tjønneland, Anne

AU - van der A, Daphne L

AU - Wareham, Nicholas J

AU - Sørensen, Thorkild Ia

AU - Loos, Ruth Jf

AU - Boeing, Heiner

PY - 2012/6/1

Y1 - 2012/6/1

N2 - Background: Genetic polymorphisms of transcription factor 7-like 2 (TCF7L2) have been associated with type 2 diabetes and BMI. Objective: The objective was to investigate whether TCF7L2 HapA is associated with weight development and whether such an association is modulated by protein intake or by the glycemic index (GI). Design: The investigation was based on prospective data from 5 cohort studies nested within the European Prospective Investigation into Cancer and Nutrition.Weight change was followed up for a mean (±SD) of 6.8 ± 2.5 y. TCF7L2 rs7903146 and rs10885406 were successfully genotyped in 11,069 individuals and used to derive HapA. Multiple logistic and linear regression analysis was applied to test for the main effect of HapA and its interaction with dietary protein or GI. Analyses from the cohorts were combined by random-effects meta-analysis. Results: HapA was associated neither with baseline BMI (0.03 ± 0.07 BMI units per allele; P = 0.6) nor with annual weight change (8.8 ± 11.7 g/y per allele; P = 0.5). However, a previously shown positive association between intake of protein, particularly of animal origin, and subsequent weight change in this population proved to be attenuated by TCF7L2 HapA (P-interaction = 0.01). We showed that weight gain becomes independent of protein intake with an increasing number of HapA alleles. Substitution of protein with either fat or carbohydrates showed the same effects. No interaction with GI was observed. Conclusion: TCF7L2 HapA attenuates the positive association between animal protein intake and long-term body weight change in middle-aged Europeans but does not interact with the GI of the diet.

AB - Background: Genetic polymorphisms of transcription factor 7-like 2 (TCF7L2) have been associated with type 2 diabetes and BMI. Objective: The objective was to investigate whether TCF7L2 HapA is associated with weight development and whether such an association is modulated by protein intake or by the glycemic index (GI). Design: The investigation was based on prospective data from 5 cohort studies nested within the European Prospective Investigation into Cancer and Nutrition.Weight change was followed up for a mean (±SD) of 6.8 ± 2.5 y. TCF7L2 rs7903146 and rs10885406 were successfully genotyped in 11,069 individuals and used to derive HapA. Multiple logistic and linear regression analysis was applied to test for the main effect of HapA and its interaction with dietary protein or GI. Analyses from the cohorts were combined by random-effects meta-analysis. Results: HapA was associated neither with baseline BMI (0.03 ± 0.07 BMI units per allele; P = 0.6) nor with annual weight change (8.8 ± 11.7 g/y per allele; P = 0.5). However, a previously shown positive association between intake of protein, particularly of animal origin, and subsequent weight change in this population proved to be attenuated by TCF7L2 HapA (P-interaction = 0.01). We showed that weight gain becomes independent of protein intake with an increasing number of HapA alleles. Substitution of protein with either fat or carbohydrates showed the same effects. No interaction with GI was observed. Conclusion: TCF7L2 HapA attenuates the positive association between animal protein intake and long-term body weight change in middle-aged Europeans but does not interact with the GI of the diet.

U2 - 10.3945/ajcn.111.014670

DO - 10.3945/ajcn.111.014670

M3 - Journal article

C2 - 22552033

SN - 0002-9165

VL - 95

SP - 1468

EP - 1476

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

IS - 6

ER -

Influence of dietary protein intake and glycemic index on the association between TCF7L2 HapA and weight gain

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