TY - JOUR
T1 - Inflammatory single nucleotide polymorphisms and the risk of atrial fibrillation: a case control study
AU - Henningsen, Kristoffer M
AU - Olesen, Morten Sig
AU - Ravn, Lasse S
AU - Dixen, Ulrik
AU - Haunsoe, Stig
AU - Bruunsgaard, Helle
AU - Svendsen, Jesper Hastrup
PY - 2011/3
Y1 - 2011/3
N2 - INTRODUCTION: Systemic inflammation is associated with atrial fibrillation (AF) and inflammatory processes are involved in the pathophysiology of AF. We hypothesized that genetic polymorphisms, which determine the rate of inflammatory cytokines, are associated with increased risk of AF. MATERIALS AND METHODS: We included 158 patients with AF and 188 healthy controls. All patients were genotyped for common single nucleotide polymorphisms (SNPs) in selected inflammatory genes. RESULTS: A case-control analysis of the investigated SNPs (IL1A-889, TNF-308, IL1B-511, IL10-592, IL10-1082, IL18-137 and IL18-607) revealed no significant differences in the frequencies of genotypes between the AF patients and the healthy controls.
AB - INTRODUCTION: Systemic inflammation is associated with atrial fibrillation (AF) and inflammatory processes are involved in the pathophysiology of AF. We hypothesized that genetic polymorphisms, which determine the rate of inflammatory cytokines, are associated with increased risk of AF. MATERIALS AND METHODS: We included 158 patients with AF and 188 healthy controls. All patients were genotyped for common single nucleotide polymorphisms (SNPs) in selected inflammatory genes. RESULTS: A case-control analysis of the investigated SNPs (IL1A-889, TNF-308, IL1B-511, IL10-592, IL10-1082, IL18-137 and IL18-607) revealed no significant differences in the frequencies of genotypes between the AF patients and the healthy controls.
U2 - 10.1007/s00011-010-0285-2
DO - 10.1007/s00011-010-0285-2
M3 - Journal article
C2 - 21132345
SN - 1023-3830
VL - 60
SP - 209
EP - 211
JO - Inflammation Research
JF - Inflammation Research
IS - 3
ER -