Inflammatory markers of CHMP2B-mediated frontotemporal dementia

Peter Roos; Marina Rode von Essen; Troels Tolstrup Nielsen; Peter Johannsen; Jette Stokholm; Anne Sigaard Bie; Gunhild Waldemar; Anja Hviid Simonsen; Amanda Heslegrave; Henrik Zetterberg; FReJA Consortium; Finn Sellebjerg; Jørgen Erik Nielsen

doi:10.1016/j.jneuroim.2018.08.009

Inflammatory markers of CHMP2B-mediated frontotemporal dementia

Peter Roos, Marina Rode von Essen, Troels Tolstrup Nielsen, Peter Johannsen, Jette Stokholm, Anne Sigaard Bie, Gunhild Waldemar, Anja Hviid Simonsen, Amanda Heslegrave, Henrik Zetterberg, FReJA Consortium, Finn Sellebjerg, Jørgen Erik Nielsen

Department of Clinical Medicine

2 Citations (Scopus)

Abstract

Histopathological studies and animal models have suggested an inflammatory component in the pathomechanism of the CHMP2B associated frontotemporal dementia (FTD-3). In this cross-sectional study, serum and cerebrospinal fluid were analyzed for inflammatory markers in CHMP2B mutation carriers. Serum levels of CCL4 were increased throughout life. Serum levels of IL-15, CXCL10, CCL22 and TNF-α were significantly associated with cognitive decline, suggesting a peripheral inflammatory response to neurodegeneration. CSF levels of sTREM2 appeared to increase more rapidly with age in CHMP2B mutation carriers. The identification of a peripheral inflammatory response to disease progression supports the involvement of an inflammatory component in FTD-3.

Original language	English
Journal	Journal of Neuroimmunology
Volume	324
Pages (from-to)	136-142
Number of pages	7
ISSN	0165-5728
DOIs	https://doi.org/10.1016/j.jneuroim.2018.08.009
Publication status	Published - 15 Nov 2018

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title = "Inflammatory markers of CHMP2B-mediated frontotemporal dementia",

abstract = "Histopathological studies and animal models have suggested an inflammatory component in the pathomechanism of the CHMP2B associated frontotemporal dementia (FTD-3). In this cross-sectional study, serum and cerebrospinal fluid were analyzed for inflammatory markers in CHMP2B mutation carriers. Serum levels of CCL4 were increased throughout life. Serum levels of IL-15, CXCL10, CCL22 and TNF-α were significantly associated with cognitive decline, suggesting a peripheral inflammatory response to neurodegeneration. CSF levels of sTREM2 appeared to increase more rapidly with age in CHMP2B mutation carriers. The identification of a peripheral inflammatory response to disease progression supports the involvement of an inflammatory component in FTD-3.",

author = "Peter Roos and {von Essen}, {Marina Rode} and Nielsen, {Troels Tolstrup} and Peter Johannsen and Jette Stokholm and Bie, {Anne Sigaard} and Gunhild Waldemar and Simonsen, {Anja Hviid} and Amanda Heslegrave and Henrik Zetterberg and {FReJA Consortium} and Finn Sellebjerg and Nielsen, {J{\o}rgen Erik}",

year = "2018",

month = nov,

day = "15",

doi = "10.1016/j.jneuroim.2018.08.009",

language = "English",

volume = "324",

pages = "136--142",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier",

}

TY - JOUR

T1 - Inflammatory markers of CHMP2B-mediated frontotemporal dementia

AU - Roos, Peter

AU - von Essen, Marina Rode

AU - Nielsen, Troels Tolstrup

AU - Johannsen, Peter

AU - Stokholm, Jette

AU - Bie, Anne Sigaard

AU - Waldemar, Gunhild

AU - Simonsen, Anja Hviid

AU - Heslegrave, Amanda

AU - Zetterberg, Henrik

AU - FReJA Consortium

AU - Sellebjerg, Finn

AU - Nielsen, Jørgen Erik

PY - 2018/11/15

Y1 - 2018/11/15

N2 - Histopathological studies and animal models have suggested an inflammatory component in the pathomechanism of the CHMP2B associated frontotemporal dementia (FTD-3). In this cross-sectional study, serum and cerebrospinal fluid were analyzed for inflammatory markers in CHMP2B mutation carriers. Serum levels of CCL4 were increased throughout life. Serum levels of IL-15, CXCL10, CCL22 and TNF-α were significantly associated with cognitive decline, suggesting a peripheral inflammatory response to neurodegeneration. CSF levels of sTREM2 appeared to increase more rapidly with age in CHMP2B mutation carriers. The identification of a peripheral inflammatory response to disease progression supports the involvement of an inflammatory component in FTD-3.

AB - Histopathological studies and animal models have suggested an inflammatory component in the pathomechanism of the CHMP2B associated frontotemporal dementia (FTD-3). In this cross-sectional study, serum and cerebrospinal fluid were analyzed for inflammatory markers in CHMP2B mutation carriers. Serum levels of CCL4 were increased throughout life. Serum levels of IL-15, CXCL10, CCL22 and TNF-α were significantly associated with cognitive decline, suggesting a peripheral inflammatory response to neurodegeneration. CSF levels of sTREM2 appeared to increase more rapidly with age in CHMP2B mutation carriers. The identification of a peripheral inflammatory response to disease progression supports the involvement of an inflammatory component in FTD-3.

U2 - 10.1016/j.jneuroim.2018.08.009

DO - 10.1016/j.jneuroim.2018.08.009

M3 - Journal article

C2 - 30193769

SN - 0165-5728

VL - 324

SP - 136

EP - 142

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

ER -

Inflammatory markers of CHMP2B-mediated frontotemporal dementia

Abstract

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