Infiltrating/sealing proximal caries lesions: a 3-year randomized clinical trial

S Martignon; K R Ekstrand; J Gomez; J S Lara; A Cortes

doi:10.1177/0022034511435328

Infiltrating/sealing proximal caries lesions: a 3-year randomized clinical trial

S Martignon, K R Ekstrand, J Gomez, J S Lara, A Cortes

Section 05 - Community Dentistry

94 Citations (Scopus)

Abstract

This randomized split-mouth controlled clinical trial aimed at assessing the therapeutic effects of infiltration vs. sealing for controlling caries progression on proximal surfaces. Out of 90 adult students/patients assessed at university clinics and agreeing to participate, 39, each with 3 proximal lesions identified radiographically around the enamel-dentin junction to the outer third of the dentin, were included. Lesions were randomly allocated for treatment to test-A (Infiltration: ICON-pre-product; DMG), test-B (Sealing: Prime-Bond-NT; Dentsply), or control-C (Placebo). Primary outcome after 1, 2, and 3 yrs of radiographically observed lesion progression was assessed by an independent examiner blinded to groups, using pair-wise and digital-subtraction readings. No adverse events occurred. In 37 participants assessed after 3 yrs, 10 lesions (A-4; B-2; C-4) progressed deep into dentin and needed operative treatment. The 3-year therapeutic effect, based on pair-wise radiographic readings between infiltration and placebo, was 37.8% (95%CI: 20.5-55.2%) and that between sealing and placebo was 29.7% (95%CI: 20.2-35.0%). One-year follow-up digital-subtraction readings showed significant differences in lesion progression between infiltration and placebo (P = 0.0012) and between sealing and placebo (P = 0.0269). The study showed that infiltration and sealing are significantly better than placebo treatment for controlling caries progression on proximal lesions. No significant difference was seen between infiltration and sealing (ClinicalTrials.gov number CT01417832).

Original language	English
Journal	The Chinese Journal of Dental Research
Volume	91
Issue number	3
Pages (from-to)	288-92
Number of pages	5
ISSN	1462-6446
DOIs	https://doi.org/10.1177/0022034511435328
Publication status	Published - Mar 2012

Keywords

Adolescent
Adult
Cariostatic Agents
Chi-Square Distribution
DMF Index
Dental Caries
Female
Humans
Male
Pit and Fissure Sealants
Radiography, Bitewing
Single-Blind Method
Statistics, Nonparametric
Subtraction Technique
Young Adult

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10.1177/0022034511435328

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title = "Infiltrating/sealing proximal caries lesions: a 3-year randomized clinical trial",

abstract = "This randomized split-mouth controlled clinical trial aimed at assessing the therapeutic effects of infiltration vs. sealing for controlling caries progression on proximal surfaces. Out of 90 adult students/patients assessed at university clinics and agreeing to participate, 39, each with 3 proximal lesions identified radiographically around the enamel-dentin junction to the outer third of the dentin, were included. Lesions were randomly allocated for treatment to test-A (Infiltration: ICON-pre-product; DMG), test-B (Sealing: Prime-Bond-NT; Dentsply), or control-C (Placebo). Primary outcome after 1, 2, and 3 yrs of radiographically observed lesion progression was assessed by an independent examiner blinded to groups, using pair-wise and digital-subtraction readings. No adverse events occurred. In 37 participants assessed after 3 yrs, 10 lesions (A-4; B-2; C-4) progressed deep into dentin and needed operative treatment. The 3-year therapeutic effect, based on pair-wise radiographic readings between infiltration and placebo, was 37.8% (95%CI: 20.5-55.2%) and that between sealing and placebo was 29.7% (95%CI: 20.2-35.0%). One-year follow-up digital-subtraction readings showed significant differences in lesion progression between infiltration and placebo (P = 0.0012) and between sealing and placebo (P = 0.0269). The study showed that infiltration and sealing are significantly better than placebo treatment for controlling caries progression on proximal lesions. No significant difference was seen between infiltration and sealing (ClinicalTrials.gov number CT01417832).",

keywords = "Adolescent, Adult, Cariostatic Agents, Chi-Square Distribution, DMF Index, Dental Caries, Female, Humans, Male, Pit and Fissure Sealants, Radiography, Bitewing, Single-Blind Method, Statistics, Nonparametric, Subtraction Technique, Young Adult",

author = "S Martignon and Ekstrand, {K R} and J Gomez and Lara, {J S} and A Cortes",

year = "2012",

month = mar,

doi = "10.1177/0022034511435328",

language = "English",

volume = "91",

pages = "288--92",

journal = "The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA)",

issn = "1462-6446",

publisher = "Quintessence Publishing",

number = "3",

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TY - JOUR

T1 - Infiltrating/sealing proximal caries lesions

T2 - a 3-year randomized clinical trial

AU - Martignon, S

AU - Ekstrand, K R

AU - Gomez, J

AU - Lara, J S

AU - Cortes, A

PY - 2012/3

Y1 - 2012/3

N2 - This randomized split-mouth controlled clinical trial aimed at assessing the therapeutic effects of infiltration vs. sealing for controlling caries progression on proximal surfaces. Out of 90 adult students/patients assessed at university clinics and agreeing to participate, 39, each with 3 proximal lesions identified radiographically around the enamel-dentin junction to the outer third of the dentin, were included. Lesions were randomly allocated for treatment to test-A (Infiltration: ICON-pre-product; DMG), test-B (Sealing: Prime-Bond-NT; Dentsply), or control-C (Placebo). Primary outcome after 1, 2, and 3 yrs of radiographically observed lesion progression was assessed by an independent examiner blinded to groups, using pair-wise and digital-subtraction readings. No adverse events occurred. In 37 participants assessed after 3 yrs, 10 lesions (A-4; B-2; C-4) progressed deep into dentin and needed operative treatment. The 3-year therapeutic effect, based on pair-wise radiographic readings between infiltration and placebo, was 37.8% (95%CI: 20.5-55.2%) and that between sealing and placebo was 29.7% (95%CI: 20.2-35.0%). One-year follow-up digital-subtraction readings showed significant differences in lesion progression between infiltration and placebo (P = 0.0012) and between sealing and placebo (P = 0.0269). The study showed that infiltration and sealing are significantly better than placebo treatment for controlling caries progression on proximal lesions. No significant difference was seen between infiltration and sealing (ClinicalTrials.gov number CT01417832).

AB - This randomized split-mouth controlled clinical trial aimed at assessing the therapeutic effects of infiltration vs. sealing for controlling caries progression on proximal surfaces. Out of 90 adult students/patients assessed at university clinics and agreeing to participate, 39, each with 3 proximal lesions identified radiographically around the enamel-dentin junction to the outer third of the dentin, were included. Lesions were randomly allocated for treatment to test-A (Infiltration: ICON-pre-product; DMG), test-B (Sealing: Prime-Bond-NT; Dentsply), or control-C (Placebo). Primary outcome after 1, 2, and 3 yrs of radiographically observed lesion progression was assessed by an independent examiner blinded to groups, using pair-wise and digital-subtraction readings. No adverse events occurred. In 37 participants assessed after 3 yrs, 10 lesions (A-4; B-2; C-4) progressed deep into dentin and needed operative treatment. The 3-year therapeutic effect, based on pair-wise radiographic readings between infiltration and placebo, was 37.8% (95%CI: 20.5-55.2%) and that between sealing and placebo was 29.7% (95%CI: 20.2-35.0%). One-year follow-up digital-subtraction readings showed significant differences in lesion progression between infiltration and placebo (P = 0.0012) and between sealing and placebo (P = 0.0269). The study showed that infiltration and sealing are significantly better than placebo treatment for controlling caries progression on proximal lesions. No significant difference was seen between infiltration and sealing (ClinicalTrials.gov number CT01417832).

KW - Adolescent

KW - Adult

KW - Cariostatic Agents

KW - Chi-Square Distribution

KW - DMF Index

KW - Dental Caries

KW - Female

KW - Humans

KW - Male

KW - Pit and Fissure Sealants

KW - Radiography, Bitewing

KW - Single-Blind Method

KW - Statistics, Nonparametric

KW - Subtraction Technique

KW - Young Adult

U2 - 10.1177/0022034511435328

DO - 10.1177/0022034511435328

M3 - Journal article

C2 - 22257664

SN - 1462-6446

VL - 91

SP - 288

EP - 292

JO - The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA)

JF - The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA)

IS - 3

ER -

Infiltrating/sealing proximal caries lesions: a 3-year randomized clinical trial

Abstract

Keywords

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