Inference of historical changes in migration rate from the lengths of migrant tracts

John E Pool; Rasmus Nielsen

doi:10.1534/genetics.108.098095

Inference of historical changes in migration rate from the lengths of migrant tracts

John E Pool, Rasmus Nielsen

Computational and RNA Biology

113 Citations (Scopus)

Abstract

After migrant chromosomes enter a population, they are progressively sliced into smaller pieces by recombination. Therefore, the length distribution of "migrant tracts" (chromosome segments with recent migrant ancestry) contains information about historical patterns of migration. Here we introduce a theoretical framework describing the migrant tract length distribution and propose a likelihood inference method to test demographic hypotheses and estimate parameters related to a historical change in migration rate. Applying this method to data from the hybridizing subspecies Mus musculus domesticus and M. m. musculus, we find evidence for an increase in the rate of hybridization. Our findings could indicate an evolutionary trajectory toward fusion rather than speciation in these taxa.

Original language	English
Journal	Genetics
Volume	181
Issue number	2
Pages (from-to)	711-9
Number of pages	8
ISSN	0016-6731
DOIs	https://doi.org/10.1534/genetics.108.098095
Publication status	Published - 2009

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10.1534/genetics.108.098095

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title = "Inference of historical changes in migration rate from the lengths of migrant tracts",

abstract = "After migrant chromosomes enter a population, they are progressively sliced into smaller pieces by recombination. Therefore, the length distribution of {"}migrant tracts{"} (chromosome segments with recent migrant ancestry) contains information about historical patterns of migration. Here we introduce a theoretical framework describing the migrant tract length distribution and propose a likelihood inference method to test demographic hypotheses and estimate parameters related to a historical change in migration rate. Applying this method to data from the hybridizing subspecies Mus musculus domesticus and M. m. musculus, we find evidence for an increase in the rate of hybridization. Our findings could indicate an evolutionary trajectory toward fusion rather than speciation in these taxa.",

author = "Pool, {John E} and Rasmus Nielsen",

note = "Keywords: Animals; Biometry; Computer Simulation; Databases, Nucleic Acid; Genetics, Population; Hybridization, Genetic; Likelihood Functions; Mice; Models, Genetic; Polymorphism, Single Nucleotide; Population Dynamics; Selection, Genetic; Species Specificity",

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AU - Pool, John E

AU - Nielsen, Rasmus

N1 - Keywords: Animals; Biometry; Computer Simulation; Databases, Nucleic Acid; Genetics, Population; Hybridization, Genetic; Likelihood Functions; Mice; Models, Genetic; Polymorphism, Single Nucleotide; Population Dynamics; Selection, Genetic; Species Specificity

PY - 2009

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N2 - After migrant chromosomes enter a population, they are progressively sliced into smaller pieces by recombination. Therefore, the length distribution of "migrant tracts" (chromosome segments with recent migrant ancestry) contains information about historical patterns of migration. Here we introduce a theoretical framework describing the migrant tract length distribution and propose a likelihood inference method to test demographic hypotheses and estimate parameters related to a historical change in migration rate. Applying this method to data from the hybridizing subspecies Mus musculus domesticus and M. m. musculus, we find evidence for an increase in the rate of hybridization. Our findings could indicate an evolutionary trajectory toward fusion rather than speciation in these taxa.

AB - After migrant chromosomes enter a population, they are progressively sliced into smaller pieces by recombination. Therefore, the length distribution of "migrant tracts" (chromosome segments with recent migrant ancestry) contains information about historical patterns of migration. Here we introduce a theoretical framework describing the migrant tract length distribution and propose a likelihood inference method to test demographic hypotheses and estimate parameters related to a historical change in migration rate. Applying this method to data from the hybridizing subspecies Mus musculus domesticus and M. m. musculus, we find evidence for an increase in the rate of hybridization. Our findings could indicate an evolutionary trajectory toward fusion rather than speciation in these taxa.

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DO - 10.1534/genetics.108.098095

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EP - 719

JO - Genetics

JF - Genetics

IS - 2

ER -

Inference of historical changes in migration rate from the lengths of migrant tracts

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