Infants with prenatally diagnosed kidney anomalies have an increased risk of urinary tract infections

TY - JOUR

T1 - Infants with prenatally diagnosed kidney anomalies have an increased risk of urinary tract infections

AU - Rasmussen, Maria

AU - Sunde, Lone

AU - Andersen, René F.

AU - Petersen, Olav B.

AU - Danish Fetal Medicine Research Group

AU - Olsen, Morten S.

AU - Tabor, Ann

AU - Zingenberg, Helle

AU - Krebs, Lone

AU - Skibsted, Lillian

PY - 2017/11

Y1 - 2017/11

N2 - Aim: This study estimated the urinary tract infection (UTI) risk in a nationwide cohort of infants prenatally diagnosed with parenchymal kidney anomalies compared with a comparison cohort. Methods: A Danish population-based nationwide cohort of foetuses diagnosed with parenchymal kidney anomalies between 2007 and 2012 had previously been identified. These were compared with foetuses without kidney anomalies who were prenatally scanned the same year. Live born infants were followed from birth until the diagnosis of UTI, emigration, death or two years of age. Cumulative incidences of UTIs were computed. Mortality was estimated using the Kaplan–Meier method. Results: We identified 412 foetuses with parenchymal kidney anomalies out of 362 069 who underwent ultrasound scans and 277 were born alive. The overall risk of a UTI before the age of two years was 19%, and it was 14% among infants without prenatally diagnosed co-occurring urinary tract malformations. The corresponding risk in the 4074 controls was 1%. After two years, mortality was 2.2% in infants with prenatally diagnosed parenchymal kidney anomalies and 0.2% in the controls. Conclusion: Infants prenatally diagnosed with parenchymal kidney anomalies had a substantially increased risk of UTI. Awareness of this increased risk may facilitate earlier diagnosis of UTIs in this population.

AB - Aim: This study estimated the urinary tract infection (UTI) risk in a nationwide cohort of infants prenatally diagnosed with parenchymal kidney anomalies compared with a comparison cohort. Methods: A Danish population-based nationwide cohort of foetuses diagnosed with parenchymal kidney anomalies between 2007 and 2012 had previously been identified. These were compared with foetuses without kidney anomalies who were prenatally scanned the same year. Live born infants were followed from birth until the diagnosis of UTI, emigration, death or two years of age. Cumulative incidences of UTIs were computed. Mortality was estimated using the Kaplan–Meier method. Results: We identified 412 foetuses with parenchymal kidney anomalies out of 362 069 who underwent ultrasound scans and 277 were born alive. The overall risk of a UTI before the age of two years was 19%, and it was 14% among infants without prenatally diagnosed co-occurring urinary tract malformations. The corresponding risk in the 4074 controls was 1%. After two years, mortality was 2.2% in infants with prenatally diagnosed parenchymal kidney anomalies and 0.2% in the controls. Conclusion: Infants prenatally diagnosed with parenchymal kidney anomalies had a substantially increased risk of UTI. Awareness of this increased risk may facilitate earlier diagnosis of UTIs in this population.

KW - Kidney dysplasia

KW - Mortality

KW - Parenchymal kidney anomalies

KW - Prenatal screening

KW - Urinary tract infections

UR - http://www.scopus.com/inward/record.url?scp=85028702032&partnerID=8YFLogxK

U2 - 10.1111/apa.14014

DO - 10.1111/apa.14014

M3 - Journal article

C2 - 28793177

AN - SCOPUS:85028702032

SN - 0803-5253

VL - 106

SP - 1875

EP - 1881

JO - Acta Paediatrica, International Journal of Paediatrics, Supplement

JF - Acta Paediatrica, International Journal of Paediatrics, Supplement

IS - 11

ER -