Induction of DNA damage by oxidised amino acids and proteins

TY - JOUR

T1 - Induction of DNA damage by oxidised amino acids and proteins

AU - Luxford, Catherine

AU - Dean, Roger T

AU - Davies, Michael Jonathan

PY - 2002

Y1 - 2002

N2 - Exposure of amino acids, peptides and proteins to radicals in the presence of O2 generates hydroperoxides in a dose-dependent manner. These hydroperoxides are stable in the absence of exogenous catalysts (e.g. heat, light, redox-active transition metal ions), but decompose rapidly in the presence of these agents to give a variety of radicals including alkoxyl (RO*), peroxyl (ROO*) and carbon-centred (R) species. These radicals are shown to react with DNA to give DNA-protein cross-links and single strand breaks.

AB - Exposure of amino acids, peptides and proteins to radicals in the presence of O2 generates hydroperoxides in a dose-dependent manner. These hydroperoxides are stable in the absence of exogenous catalysts (e.g. heat, light, redox-active transition metal ions), but decompose rapidly in the presence of these agents to give a variety of radicals including alkoxyl (RO*), peroxyl (ROO*) and carbon-centred (R) species. These radicals are shown to react with DNA to give DNA-protein cross-links and single strand breaks.

KW - Amino Acids

KW - Animals

KW - Cattle

KW - DNA Damage

KW - Electrophoresis, Agar Gel

KW - Hydrogen Peroxide

KW - Oxidation-Reduction

KW - Proteins

M3 - Journal article

C2 - 12014851

SN - 1389-5729

VL - 3

SP - 95

EP - 102

JO - Biogerontology

JF - Biogerontology

IS - 1-2

ER -