Alifrangis, M., Nag, S., Schousboe, M. L., Ishengoma, D., Lusingu, J., Pota, H., Kavishe, R. A., Pearce, R., Ord, R., Lynch, C., Dejene, S., Cox, J., Rwakimari, J., Minja, D. T. R., Lemnge, M. M., & Roper, C. (2014). Independent origin of Plasmodium falciparum antifolate super-resistance, Uganda, Tanzania, and Ethiopia. Emerging Infectious Diseases (Print Edition), 20(8), 1280-6. https://doi.org/10.3201/eid2008.131897
Independent origin of Plasmodium falciparum antifolate super-resistance, Uganda, Tanzania, and Ethiopia. /
Alifrangis, Michael; Nag, Sidsel; Schousboe, Mette L et al.
In:
Emerging Infectious Diseases (Print Edition), Vol. 20, No. 8, 08.2014, p. 1280-6.
Research output: Contribution to journal › Journal article › Research › peer-review
Alifrangis, M, Nag, S, Schousboe, ML, Ishengoma, D, Lusingu, J, Pota, H, Kavishe, RA, Pearce, R, Ord, R, Lynch, C, Dejene, S, Cox, J, Rwakimari, J, Minja, DTR, Lemnge, MM & Roper, C 2014, 'Independent origin of Plasmodium falciparum antifolate super-resistance, Uganda, Tanzania, and Ethiopia', Emerging Infectious Diseases (Print Edition), vol. 20, no. 8, pp. 1280-6. https://doi.org/10.3201/eid2008.131897
Alifrangis M, Nag S, Schousboe ML, Ishengoma D, Lusingu J, Pota H et al. Independent origin of Plasmodium falciparum antifolate super-resistance, Uganda, Tanzania, and Ethiopia. Emerging Infectious Diseases (Print Edition). 2014 Aug;20(8):1280-6. doi: 10.3201/eid2008.131897
Alifrangis, Michael ; Nag, Sidsel ; Schousboe, Mette L et al. / Independent origin of Plasmodium falciparum antifolate super-resistance, Uganda, Tanzania, and Ethiopia. In: Emerging Infectious Diseases (Print Edition). 2014 ; Vol. 20, No. 8. pp. 1280-6.
@article{30537c4b0e9f4a8d8e59cfbc01792d48,
title = "Independent origin of Plasmodium falciparum antifolate super-resistance, Uganda, Tanzania, and Ethiopia",
abstract = "Super-resistant Plasmodium falciparum threatens the effectiveness of sulfadoxine-pyrimethamine in intermittent preventive treatment for malaria during pregnancy. It is characterized by the A581G Pfdhps mutation on a background of the double-mutant Pfdhps and the triple-mutant Pfdhfr. Using samples collected during 2004-2008, we investigated the evolutionary origin of the A581G mutation by characterizing microsatellite diversity flanking Pfdhps triple-mutant (437G+540E+581G) alleles from 3 locations in eastern Africa and comparing it with double-mutant (437G+540E) alleles from the same area. In Ethiopia, both alleles derived from 1 lineage that was distinct from those in Uganda and Tanzania. Uganda and Tanzania triple mutants derived from the previously characterized southeastern Africa double-mutant lineage. The A581G mutation has occurred multiple times on local Pfdhps double-mutant backgrounds; however, a novel microsatellite allele incorporated into the Tanzania lineage since 2004 illustrates the local expansion of emergent triple-mutant lineages.",
author = "Michael Alifrangis and Sidsel Nag and Schousboe, {Mette L} and Deus Ishengoma and John Lusingu and Hirva Pota and Kavishe, {Reginald A} and Richard Pearce and Rosalynn Ord and Caroline Lynch and Seyoum Dejene and Jonathan Cox and John Rwakimari and Minja, {Daniel T R} and Lemnge, {Martha M} and Cally Roper",
year = "2014",
month = aug,
doi = "10.3201/eid2008.131897",
language = "English",
volume = "20",
pages = "1280--6",
journal = "Emerging Infectious Diseases (Print Edition)",
issn = "1080-6040",
publisher = "CDC Centers for Disease Control and Prevention",
number = "8",
}
TY - JOUR
T1 - Independent origin of Plasmodium falciparum antifolate super-resistance, Uganda, Tanzania, and Ethiopia
AU - Alifrangis, Michael
AU - Nag, Sidsel
AU - Schousboe, Mette L
AU - Ishengoma, Deus
AU - Lusingu, John
AU - Pota, Hirva
AU - Kavishe, Reginald A
AU - Pearce, Richard
AU - Ord, Rosalynn
AU - Lynch, Caroline
AU - Dejene, Seyoum
AU - Cox, Jonathan
AU - Rwakimari, John
AU - Minja, Daniel T R
AU - Lemnge, Martha M
AU - Roper, Cally
PY - 2014/8
Y1 - 2014/8
N2 - Super-resistant Plasmodium falciparum threatens the effectiveness of sulfadoxine-pyrimethamine in intermittent preventive treatment for malaria during pregnancy. It is characterized by the A581G Pfdhps mutation on a background of the double-mutant Pfdhps and the triple-mutant Pfdhfr. Using samples collected during 2004-2008, we investigated the evolutionary origin of the A581G mutation by characterizing microsatellite diversity flanking Pfdhps triple-mutant (437G+540E+581G) alleles from 3 locations in eastern Africa and comparing it with double-mutant (437G+540E) alleles from the same area. In Ethiopia, both alleles derived from 1 lineage that was distinct from those in Uganda and Tanzania. Uganda and Tanzania triple mutants derived from the previously characterized southeastern Africa double-mutant lineage. The A581G mutation has occurred multiple times on local Pfdhps double-mutant backgrounds; however, a novel microsatellite allele incorporated into the Tanzania lineage since 2004 illustrates the local expansion of emergent triple-mutant lineages.
AB - Super-resistant Plasmodium falciparum threatens the effectiveness of sulfadoxine-pyrimethamine in intermittent preventive treatment for malaria during pregnancy. It is characterized by the A581G Pfdhps mutation on a background of the double-mutant Pfdhps and the triple-mutant Pfdhfr. Using samples collected during 2004-2008, we investigated the evolutionary origin of the A581G mutation by characterizing microsatellite diversity flanking Pfdhps triple-mutant (437G+540E+581G) alleles from 3 locations in eastern Africa and comparing it with double-mutant (437G+540E) alleles from the same area. In Ethiopia, both alleles derived from 1 lineage that was distinct from those in Uganda and Tanzania. Uganda and Tanzania triple mutants derived from the previously characterized southeastern Africa double-mutant lineage. The A581G mutation has occurred multiple times on local Pfdhps double-mutant backgrounds; however, a novel microsatellite allele incorporated into the Tanzania lineage since 2004 illustrates the local expansion of emergent triple-mutant lineages.
U2 - 10.3201/eid2008.131897
DO - 10.3201/eid2008.131897
M3 - Journal article
C2 - 25061906
SN - 1080-6040
VL - 20
SP - 1280
EP - 1286
JO - Emerging Infectious Diseases (Print Edition)
JF - Emerging Infectious Diseases (Print Edition)
IS - 8
ER -
