Increasing incidence and survival of head and neck cancers in Denmark: a nation-wide study from 1980 to 2014

Kathrine Kronberg Jakobsen; Christian Grønhøj; David Hebbelstrup Jensen; Kirstine Kim Schmidt Karnov; Tina Klitmøller Agander; Lena Specht; Christian von Buchwald

doi:10.1080/0284186x.2018.1438657

Increasing incidence and survival of head and neck cancers in Denmark: a nation-wide study from 1980 to 2014

Kathrine Kronberg Jakobsen, Christian Grønhøj, David Hebbelstrup Jensen, Kirstine Kim Schmidt Karnov, Tina Klitmøller Agander, Lena Specht, Christian von Buchwald

Department of Clinical Medicine

23 Citations (Scopus)

Abstract

BACKGROUND: The purpose of the study was to determine trends in age-adjusted incidence rates (AAIR) and survival probability in head and neck cancers (HNCs) in the Danish population from 1980 to 2014.

MATERIAL AND METHODS: All patients registered with HNC in the nationwide Danish Cancer Registry from 1980 to 2014 were included. We evaluated the AAIR per 100,000 and the average annual percent change (AAPC). The relative survival probability at 5 years was calculated in relation to gender, anatomical location and histology, and we constructed age-period-cohort models of incidence.

RESULTS: About 34,606 patients were included (64.7% men). The AAIR increased from 9.1 per 100,000 in 1980 to 17.4 per 100,000 in 2014 with an AAPC of 2.1%. The greatest incidence increase was observed in oropharyngeal cancer (AAPC: 5.4%) followed by hypopharyngeal cancer (AAPC: 4.2%). Adenocarcinomas had the highest AAPC (5.0%) followed by squamous cell carcinomas (AAPC: 2.0%). The AAPC was significantly higher in women (2.4%) compared with men (1.6%). For all HNC patients, the relative survival at 5 years rose significantly from 49.0% in 1980-1984 to 62.4% in 2010-2014. Women had a significantly higher survival than men with a relative survival of 61.7% compared to 50.0% in men. Laryngeal cancer had the best survival probability of cancers in the upper aerodigestive tract with hypopharyngeal cancer having the poorest survival.

CONCLUSION: This nation-wide study showed a significant rise in incidence of HNC for men and women along with a significant increase in relative survival. Oropharyngeal cancer had the highest increase in incidence followed by hypopharyngeal cancer which showed the poorest survival of HNCs.

Original language	English
Journal	Acta Oncologica
Volume	57
Issue number	9
Pages (from-to)	1143-1151
Number of pages	9
ISSN	0284-186X
DOIs	https://doi.org/10.1080/0284186x.2018.1438657
Publication status	Published - 2 Sept 2018

Keywords

Denmark/epidemiology
Female
Follow-Up Studies
Head and Neck Neoplasms/classification
Humans
Incidence
Male
Middle Aged
Registries
Survival Rate/trends

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1080/0284186x.2018.1438657

0284186X.2018.1438657?needAccess=trueFinal published version, 2.94 MB

Cite this

@article{a36cce2b02b64ea68fbc03e06d96dcab,

title = "Increasing incidence and survival of head and neck cancers in Denmark: a nation-wide study from 1980 to 2014",

abstract = "BACKGROUND: The purpose of the study was to determine trends in age-adjusted incidence rates (AAIR) and survival probability in head and neck cancers (HNCs) in the Danish population from 1980 to 2014.MATERIAL AND METHODS: All patients registered with HNC in the nationwide Danish Cancer Registry from 1980 to 2014 were included. We evaluated the AAIR per 100,000 and the average annual percent change (AAPC). The relative survival probability at 5 years was calculated in relation to gender, anatomical location and histology, and we constructed age-period-cohort models of incidence.RESULTS: About 34,606 patients were included (64.7% men). The AAIR increased from 9.1 per 100,000 in 1980 to 17.4 per 100,000 in 2014 with an AAPC of 2.1%. The greatest incidence increase was observed in oropharyngeal cancer (AAPC: 5.4%) followed by hypopharyngeal cancer (AAPC: 4.2%). Adenocarcinomas had the highest AAPC (5.0%) followed by squamous cell carcinomas (AAPC: 2.0%). The AAPC was significantly higher in women (2.4%) compared with men (1.6%). For all HNC patients, the relative survival at 5 years rose significantly from 49.0% in 1980-1984 to 62.4% in 2010-2014. Women had a significantly higher survival than men with a relative survival of 61.7% compared to 50.0% in men. Laryngeal cancer had the best survival probability of cancers in the upper aerodigestive tract with hypopharyngeal cancer having the poorest survival.CONCLUSION: This nation-wide study showed a significant rise in incidence of HNC for men and women along with a significant increase in relative survival. Oropharyngeal cancer had the highest increase in incidence followed by hypopharyngeal cancer which showed the poorest survival of HNCs.",

keywords = "Denmark/epidemiology, Female, Follow-Up Studies, Head and Neck Neoplasms/classification, Humans, Incidence, Male, Middle Aged, Registries, Survival Rate/trends",

author = "Jakobsen, {Kathrine Kronberg} and Christian Gr{\o}nh{\o}j and Jensen, {David Hebbelstrup} and Karnov, {Kirstine Kim Schmidt} and Agander, {Tina Klitm{\o}ller} and Lena Specht and {von Buchwald}, Christian",

year = "2018",

month = sep,

day = "2",

doi = "10.1080/0284186x.2018.1438657",

language = "English",

volume = "57",

pages = "1143--1151",

journal = "Acta Oncologica",

issn = "0284-186X",

publisher = "Taylor & Francis",

number = "9",

}

TY - JOUR

T1 - Increasing incidence and survival of head and neck cancers in Denmark

T2 - a nation-wide study from 1980 to 2014

AU - Jakobsen, Kathrine Kronberg

AU - Grønhøj, Christian

AU - Jensen, David Hebbelstrup

AU - Karnov, Kirstine Kim Schmidt

AU - Agander, Tina Klitmøller

AU - Specht, Lena

AU - von Buchwald, Christian

PY - 2018/9/2

Y1 - 2018/9/2

N2 - BACKGROUND: The purpose of the study was to determine trends in age-adjusted incidence rates (AAIR) and survival probability in head and neck cancers (HNCs) in the Danish population from 1980 to 2014.MATERIAL AND METHODS: All patients registered with HNC in the nationwide Danish Cancer Registry from 1980 to 2014 were included. We evaluated the AAIR per 100,000 and the average annual percent change (AAPC). The relative survival probability at 5 years was calculated in relation to gender, anatomical location and histology, and we constructed age-period-cohort models of incidence.RESULTS: About 34,606 patients were included (64.7% men). The AAIR increased from 9.1 per 100,000 in 1980 to 17.4 per 100,000 in 2014 with an AAPC of 2.1%. The greatest incidence increase was observed in oropharyngeal cancer (AAPC: 5.4%) followed by hypopharyngeal cancer (AAPC: 4.2%). Adenocarcinomas had the highest AAPC (5.0%) followed by squamous cell carcinomas (AAPC: 2.0%). The AAPC was significantly higher in women (2.4%) compared with men (1.6%). For all HNC patients, the relative survival at 5 years rose significantly from 49.0% in 1980-1984 to 62.4% in 2010-2014. Women had a significantly higher survival than men with a relative survival of 61.7% compared to 50.0% in men. Laryngeal cancer had the best survival probability of cancers in the upper aerodigestive tract with hypopharyngeal cancer having the poorest survival.CONCLUSION: This nation-wide study showed a significant rise in incidence of HNC for men and women along with a significant increase in relative survival. Oropharyngeal cancer had the highest increase in incidence followed by hypopharyngeal cancer which showed the poorest survival of HNCs.

AB - BACKGROUND: The purpose of the study was to determine trends in age-adjusted incidence rates (AAIR) and survival probability in head and neck cancers (HNCs) in the Danish population from 1980 to 2014.MATERIAL AND METHODS: All patients registered with HNC in the nationwide Danish Cancer Registry from 1980 to 2014 were included. We evaluated the AAIR per 100,000 and the average annual percent change (AAPC). The relative survival probability at 5 years was calculated in relation to gender, anatomical location and histology, and we constructed age-period-cohort models of incidence.RESULTS: About 34,606 patients were included (64.7% men). The AAIR increased from 9.1 per 100,000 in 1980 to 17.4 per 100,000 in 2014 with an AAPC of 2.1%. The greatest incidence increase was observed in oropharyngeal cancer (AAPC: 5.4%) followed by hypopharyngeal cancer (AAPC: 4.2%). Adenocarcinomas had the highest AAPC (5.0%) followed by squamous cell carcinomas (AAPC: 2.0%). The AAPC was significantly higher in women (2.4%) compared with men (1.6%). For all HNC patients, the relative survival at 5 years rose significantly from 49.0% in 1980-1984 to 62.4% in 2010-2014. Women had a significantly higher survival than men with a relative survival of 61.7% compared to 50.0% in men. Laryngeal cancer had the best survival probability of cancers in the upper aerodigestive tract with hypopharyngeal cancer having the poorest survival.CONCLUSION: This nation-wide study showed a significant rise in incidence of HNC for men and women along with a significant increase in relative survival. Oropharyngeal cancer had the highest increase in incidence followed by hypopharyngeal cancer which showed the poorest survival of HNCs.

KW - Denmark/epidemiology

KW - Female

KW - Follow-Up Studies

KW - Head and Neck Neoplasms/classification

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Registries

KW - Survival Rate/trends

U2 - 10.1080/0284186x.2018.1438657

DO - 10.1080/0284186x.2018.1438657

M3 - Journal article

C2 - 29447088

SN - 0284-186X

VL - 57

SP - 1143

EP - 1151

JO - Acta Oncologica

JF - Acta Oncologica

IS - 9

ER -

Increasing incidence and survival of head and neck cancers in Denmark: a nation-wide study from 1980 to 2014

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this