Increased short-term variability of repolarization predicts d-sotalol-induced torsades de pointes in dogs

TY - JOUR

T1 - Increased short-term variability of repolarization predicts d-sotalol-induced torsades de pointes in dogs

AU - Thomsen, Morten Bækgaard

AU - Verduyn, S Cora

AU - Stengl, Milan

AU - Beekman, Jet D M

AU - de Pater, Geert

AU - van Opstal, Jurren

AU - Volders, Paul G A

AU - Vos, Marc A

PY - 2004/10/19

Y1 - 2004/10/19

N2 - Identification of patients at risk for drug-induced torsades de pointes arrhythmia (TdP) is difficult. Increased temporal lability of repolarization has been suggested as being valuable to predict proarrhythmia. The predictive value of different repolarization parameters, including beat-to-beat variability of repolarization (BVR), was compared in this serial investigation in dogs with chronic AV block.

AB - Identification of patients at risk for drug-induced torsades de pointes arrhythmia (TdP) is difficult. Increased temporal lability of repolarization has been suggested as being valuable to predict proarrhythmia. The predictive value of different repolarization parameters, including beat-to-beat variability of repolarization (BVR), was compared in this serial investigation in dogs with chronic AV block.

KW - Action Potentials

KW - Adrenergic beta-Antagonists

KW - Animals

KW - Cardiac Complexes, Premature

KW - Chronic Disease

KW - Disease Susceptibility

KW - Dogs

KW - Dose-Response Relationship, Drug

KW - Electrocardiography

KW - Female

KW - Heart Block

KW - Heart Conduction System

KW - Heart Ventricles

KW - Male

KW - Predictive Value of Tests

KW - Sotalol

KW - Torsades de Pointes

U2 - 10.1161/01.CIR.0000145162.64183.C8

DO - 10.1161/01.CIR.0000145162.64183.C8

M3 - Journal article

C2 - 15477402

SN - 0009-7322

VL - 110

SP - 2453

EP - 2459

JO - Circulation

JF - Circulation

IS - 16

ER -