Increased serum YKL-40 in patients with pulmonary sarcoidosis--a potential marker of disease activity?

TY - JOUR

T1 - Increased serum YKL-40 in patients with pulmonary sarcoidosis--a potential marker of disease activity?

AU - Johansen, Julia S

AU - Milman, Nils

AU - Hansen, Michael

AU - Garbarsch, Charly

AU - Price, Paul A

AU - Graudal, Niels

PY - 2005/4/1

Y1 - 2005/4/1

N2 - YKL-40, a growth factor for fibroblasts and vascular endothelial cells, is secreted by macrophages and neutrophils. Elevated serum YKL-40 is found in patients with diseases characterized by inflammation, tissue remodelling and ongoing fibrosis. The aim was to evaluate whether macrophages and giant cells in the granulomatous sarcoid lesions of patients with pulmonary sarcoidosis produce YKL-40 and to determine whether serum YKL-40 in these patients were associated with disease activity.

AB - YKL-40, a growth factor for fibroblasts and vascular endothelial cells, is secreted by macrophages and neutrophils. Elevated serum YKL-40 is found in patients with diseases characterized by inflammation, tissue remodelling and ongoing fibrosis. The aim was to evaluate whether macrophages and giant cells in the granulomatous sarcoid lesions of patients with pulmonary sarcoidosis produce YKL-40 and to determine whether serum YKL-40 in these patients were associated with disease activity.

U2 - http://dx.doi.org/10.1016/j.rmed.2004.09.016

DO - http://dx.doi.org/10.1016/j.rmed.2004.09.016

M3 - Journal article

SN - 0954-6111

VL - 99

SP - 396

EP - 402

JO - Respiratory Medicine

JF - Respiratory Medicine

IS - 4

ER -