TY - JOUR
T1 - Increased risk of borderline ovarian tumors in women with a history of pelvic inflammatory disease
T2 - A nationwide population-based cohort study
AU - Rasmussen, Christina B
AU - Jensen, Allan
AU - Albieri, Vanna
AU - Andersen, Klaus K.
AU - Kjaer, Susanne K.
PY - 2016
Y1 - 2016
N2 - Objective Some studies suggest that pelvic inflammatory disease (PID) is a potential risk factor for ovarian cancer. However, only few studies have investigated the association between PID and risk of borderline ovarian tumors. We conducted a population-based cohort study to investigate the association between PID and risk of borderline ovarian tumors. Methods Using various nationwide Danish registries we identified all women in Denmark during 1978–2012, who were born during 1940–1970 (n = 1,318,925). Of these, 81,263 women were diagnosed with PID in the study period, and 2736 women had a borderline ovarian tumor (1290 serous and 1344 mucinous). Hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between PID and risk of borderline tumors were estimated using Cox regression models with adjustment for potential confounders. Results A history of PID was associated with an increased risk of borderline ovarian tumors (HR = 1.39; 95% CI: 1.19–1.61). However, histotype-specific analyses revealed significant variation in risk as PID was only associated with an increased risk of serous borderline tumors (HR = 1.85; 95% CI: 1.52–2.24), but not with mucinous borderline tumors (HR = 1.06; 95% CI: 0.83–1.35). Conclusions PID is associated with an increased risk of serous borderline tumors. Further research on the potential underlying biological mechanisms and on the identification of the subset of women with PID who are at increased risk of serous borderline tumors is warranted.
AB - Objective Some studies suggest that pelvic inflammatory disease (PID) is a potential risk factor for ovarian cancer. However, only few studies have investigated the association between PID and risk of borderline ovarian tumors. We conducted a population-based cohort study to investigate the association between PID and risk of borderline ovarian tumors. Methods Using various nationwide Danish registries we identified all women in Denmark during 1978–2012, who were born during 1940–1970 (n = 1,318,925). Of these, 81,263 women were diagnosed with PID in the study period, and 2736 women had a borderline ovarian tumor (1290 serous and 1344 mucinous). Hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between PID and risk of borderline tumors were estimated using Cox regression models with adjustment for potential confounders. Results A history of PID was associated with an increased risk of borderline ovarian tumors (HR = 1.39; 95% CI: 1.19–1.61). However, histotype-specific analyses revealed significant variation in risk as PID was only associated with an increased risk of serous borderline tumors (HR = 1.85; 95% CI: 1.52–2.24), but not with mucinous borderline tumors (HR = 1.06; 95% CI: 0.83–1.35). Conclusions PID is associated with an increased risk of serous borderline tumors. Further research on the potential underlying biological mechanisms and on the identification of the subset of women with PID who are at increased risk of serous borderline tumors is warranted.
KW - Borderline ovarian tumor
KW - Cohort study
KW - Inflammation
KW - Pelvic inflammatory disease
KW - Risk factor
U2 - 10.1016/j.ygyno.2016.08.318
DO - 10.1016/j.ygyno.2016.08.318
M3 - Journal article
C2 - 27549433
AN - SCOPUS:84995380054
SN - 0090-8258
VL - 143
SP - 346
EP - 351
JO - Gynecologic Oncology
JF - Gynecologic Oncology
IS - 2
ER -
