Increased risk of arterial thromboembolic events after Staphylococcus aureus bacteremia: A matched cohort study

TY - JOUR

T1 - Increased risk of arterial thromboembolic events after Staphylococcus aureus bacteremia

T2 - A matched cohort study

AU - Mejer, N

AU - Gotland, N

AU - Uhre, M L

AU - Westh, H

AU - Schønheyder, H C

AU - Petersen, A

AU - Jensen, A G

AU - Larsen, A R

AU - Skov, R

AU - Benfield, T

AU - Danish Staphylococcal Bacteremia Study Group

N1 - Copyright © 2015 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

PY - 2015/8/1

Y1 - 2015/8/1

N2 - Objectives: An association between infection and arterial thromboembolic events (ATE) has been suggested. Here we examined the risk of myocardial infarction (MI), stroke and other ATE after Staphylococcus aureus bacteremia (SAB). Methods: Danish register-based nation-wide observational cohort study between 1995 and 2008 with matched control subjects from the general population. Results: Within a year, 278 of 15,669 SAB patients and 2570 of 156,690 controls developed MI, stroke or another ATE. The incidence rates among SAB patients were highest within the first 30 days and decreased over a year. The adjusted relative risk of MI, stroke and other ATE during the first 30 days after SAB in patients compared to controls were 2.2 (95% CI: 1.6-3.1), 5.5 (95% CI: 3.8-8.3) and 15.5 (95% CI: 6.9-35), respectively. Compared to controls, the increased adjusted relative risk persisted for 30 days for MI, 180 days for stroke and one year for other ATE. Increasing age, hypertension, atrial flutter/fibrillation, prior ATE and endocarditis in SAB patients were associated with an increased risk of ATE. Conclusions: SAB was associated with a short-term increased risk of ATE that persisted longer dependent on type of event. Studies are warranted to investigate treatment strategies to diminish ATE after SAB.

AB - Objectives: An association between infection and arterial thromboembolic events (ATE) has been suggested. Here we examined the risk of myocardial infarction (MI), stroke and other ATE after Staphylococcus aureus bacteremia (SAB). Methods: Danish register-based nation-wide observational cohort study between 1995 and 2008 with matched control subjects from the general population. Results: Within a year, 278 of 15,669 SAB patients and 2570 of 156,690 controls developed MI, stroke or another ATE. The incidence rates among SAB patients were highest within the first 30 days and decreased over a year. The adjusted relative risk of MI, stroke and other ATE during the first 30 days after SAB in patients compared to controls were 2.2 (95% CI: 1.6-3.1), 5.5 (95% CI: 3.8-8.3) and 15.5 (95% CI: 6.9-35), respectively. Compared to controls, the increased adjusted relative risk persisted for 30 days for MI, 180 days for stroke and one year for other ATE. Increasing age, hypertension, atrial flutter/fibrillation, prior ATE and endocarditis in SAB patients were associated with an increased risk of ATE. Conclusions: SAB was associated with a short-term increased risk of ATE that persisted longer dependent on type of event. Studies are warranted to investigate treatment strategies to diminish ATE after SAB.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Bacteremia

KW - Cohort Studies

KW - Denmark

KW - Female

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Myocardial Infarction

KW - Risk Assessment

KW - Staphylococcal Infections

KW - Stroke

KW - Thromboembolism

KW - Time Factors

KW - Young Adult

U2 - 10.1016/j.jinf.2015.03.010

DO - 10.1016/j.jinf.2015.03.010

M3 - Journal article

C2 - 25936743

SN - 0163-4453

VL - 71

SP - 167

EP - 178

JO - Journal of Infection

JF - Journal of Infection

IS - 2

ER -