Increased orosomucoid in urine is an independent predictor of cardiovascular and all-cause mortality in patients with type 2 diabetes at 10 years of follow-up

TY - JOUR

T1 - Increased orosomucoid in urine is an independent predictor of cardiovascular and all-cause mortality in patients with type 2 diabetes at 10 years of follow-up

AU - Svendstrup, Mathilde

AU - Christiansen, Merete Skovdal

AU - Magid, Erik

AU - Hommel, Eva

AU - Feldt-Rasmussen, Bo

PY - 2013/11

Y1 - 2013/11

N2 - Aims To evaluate whether increased urinary orosomucoid excretion rate (UOER) is an independent predictor of cardiovascular and all-cause mortality in type 2 diabetes (T2DM) and type 1 diabetes (T1DM) at 10 years of follow-up. Method We followed 430 patients with T2DM and 148 patients with T1DM until emigration, death or November 2011. We measured UOER levels in overnight urine samples. Results Descriptive data are given in the article. In patients with T2DM and T1DM, all-cause mortality (log-rank test, p < 0.01 for both types) and cardiovascular mortality (log-rank test, p < 0.01 for T2DM and p = 0.04 for T1DM) were significantly higher in patients with increased UOER. Normoalbuminuric patients with T2DM and increased UOER levels had higher all-cause and cardiovascular mortality (log-rank test, p < 0.01 for both types). UOER was independently predictive of all-cause (HR 1.52; 95% CI 1.10-2.09; p = 0.01) and cardiovascular (HR 2.31; 95% CI 1.46-3.66; p < 0.01) mortality in patients with T2DM, but not in patients with T1DM. Conclusion UOER is an independent predictor of all-cause and cardiovascular mortality even in normoalbuminuric patients with T2DM at 10 years of follow-up. Further studies are needed in order to evaluate the prognostic and clinical relevance.

AB - Aims To evaluate whether increased urinary orosomucoid excretion rate (UOER) is an independent predictor of cardiovascular and all-cause mortality in type 2 diabetes (T2DM) and type 1 diabetes (T1DM) at 10 years of follow-up. Method We followed 430 patients with T2DM and 148 patients with T1DM until emigration, death or November 2011. We measured UOER levels in overnight urine samples. Results Descriptive data are given in the article. In patients with T2DM and T1DM, all-cause mortality (log-rank test, p < 0.01 for both types) and cardiovascular mortality (log-rank test, p < 0.01 for T2DM and p = 0.04 for T1DM) were significantly higher in patients with increased UOER. Normoalbuminuric patients with T2DM and increased UOER levels had higher all-cause and cardiovascular mortality (log-rank test, p < 0.01 for both types). UOER was independently predictive of all-cause (HR 1.52; 95% CI 1.10-2.09; p = 0.01) and cardiovascular (HR 2.31; 95% CI 1.46-3.66; p < 0.01) mortality in patients with T2DM, but not in patients with T1DM. Conclusion UOER is an independent predictor of all-cause and cardiovascular mortality even in normoalbuminuric patients with T2DM at 10 years of follow-up. Further studies are needed in order to evaluate the prognostic and clinical relevance.

U2 - 10.1016/j.jdiacomp.2013.05.008

DO - 10.1016/j.jdiacomp.2013.05.008

M3 - Journal article

C2 - 23932410

SN - 1056-8727

VL - 27

SP - 570

EP - 575

JO - Journal of Diabetes and its Complications

JF - Journal of Diabetes and its Complications

IS - 6

ER -