Increased mortality in patients hospitalized with primary hyperparathyroidism during the period 1977-1993 in Denmark

TY - JOUR

T1 - Increased mortality in patients hospitalized with primary hyperparathyroidism during the period 1977-1993 in Denmark

AU - Øgard, Christina G

AU - Engholm, Gerda

AU - Almdal, Thomas P

AU - Vestergaard, Henrik

PY - 2004/1

Y1 - 2004/1

N2 - The aim of the present study was to determine whether patients with the incident hospital diagnosis of primary hyperparathyroidism (PHPT) in Denmark during the period 1977-1993 had an increased mortality from cardiovascular disease and cancer compared to the rest of the Danish population. In a random sample of half of the Danish population, all patients with an incident hospital diagnosis of PHPT were identified in the National Hospital Patients Register. The mortality in the cohort was analyzed and compared with the background population. A cohort of 1578 patients was identified. Follow-up of 1179 women and 376 men, who did not die in the same month as the incident PHPT diagnosis, was made through 1993. Of these, 312 (20%) died within the follow-up period. The standard mortality ratio (SMR) for women was 1.7 (95% confidence interval [95% CI]: 1.5-1.9). SMR for men was 1.6 (95% CI: 1.3-2.0). In women an increased mortality from ischemic heart disease, cerebrovascular disease, and cancer was found. In men an increased mortality from cerebrovascular disease and cancer was found.

AB - The aim of the present study was to determine whether patients with the incident hospital diagnosis of primary hyperparathyroidism (PHPT) in Denmark during the period 1977-1993 had an increased mortality from cardiovascular disease and cancer compared to the rest of the Danish population. In a random sample of half of the Danish population, all patients with an incident hospital diagnosis of PHPT were identified in the National Hospital Patients Register. The mortality in the cohort was analyzed and compared with the background population. A cohort of 1578 patients was identified. Follow-up of 1179 women and 376 men, who did not die in the same month as the incident PHPT diagnosis, was made through 1993. Of these, 312 (20%) died within the follow-up period. The standard mortality ratio (SMR) for women was 1.7 (95% confidence interval [95% CI]: 1.5-1.9). SMR for men was 1.6 (95% CI: 1.3-2.0). In women an increased mortality from ischemic heart disease, cerebrovascular disease, and cancer was found. In men an increased mortality from cerebrovascular disease and cancer was found.

KW - Cardiovascular Diseases

KW - Denmark

KW - Female

KW - Follow-Up Studies

KW - Hospitalization

KW - Humans

KW - Hyperparathyroidism

KW - Male

KW - Middle Aged

KW - Neoplasms

U2 - 10.1007/s00268-003-7046-0

DO - 10.1007/s00268-003-7046-0

M3 - Journal article

C2 - 14648050

SN - 0364-2313

VL - 28

SP - 108

EP - 111

JO - World Journal of Surgery

JF - World Journal of Surgery

IS - 1

ER -