Increased metabolic flexibility and complexity in a long-lived growth hormone insensitive mouse model

TY - JOUR

T1 - Increased metabolic flexibility and complexity in a long-lived growth hormone insensitive mouse model

AU - Lee Hong, S.

AU - Longo, Kenneth A.

AU - Gosney, Elahu

AU - Kopchick, John J.

PY - 2014/3/17

Y1 - 2014/3/17

N2 - The goal of this study was to test whether the "loss of the complexity" hypothesis can be applied to compare the metabolic patterns of mouse models with known differences in metabolic and endocrine function as well as life span. Here, we compare the complexity of locomotor activity and metabolic patterns (energy expenditure, VO2, and respiratory quotient) of the long-lived growth hormone receptor gene deleted mice (GHR -/-) and their wild-type littermates. Using approximate entropy as a measure of complexity, we observed greater metabolic complexity, as indicated by greater irregularity in the physiological fluctuations of the GHR-/- mice. Further analysis of the data also revealed lower energy costs of locomotor activity and a stronger relationship between locomotor activity and respiratory quotient in the GHR-/- mice relative to controls. These findings suggest underlying differences in metabolic modulation in the GHR -/- mice revealed especially through measures of complexity of their time-dependent fluctuations.

AB - The goal of this study was to test whether the "loss of the complexity" hypothesis can be applied to compare the metabolic patterns of mouse models with known differences in metabolic and endocrine function as well as life span. Here, we compare the complexity of locomotor activity and metabolic patterns (energy expenditure, VO2, and respiratory quotient) of the long-lived growth hormone receptor gene deleted mice (GHR -/-) and their wild-type littermates. Using approximate entropy as a measure of complexity, we observed greater metabolic complexity, as indicated by greater irregularity in the physiological fluctuations of the GHR-/- mice. Further analysis of the data also revealed lower energy costs of locomotor activity and a stronger relationship between locomotor activity and respiratory quotient in the GHR-/- mice relative to controls. These findings suggest underlying differences in metabolic modulation in the GHR -/- mice revealed especially through measures of complexity of their time-dependent fluctuations.

KW - Animal model

KW - Growth hormone

KW - Longevity

KW - Metabolism

UR - http://www.scopus.com/inward/record.url?scp=84896747719&partnerID=8YFLogxK

U2 - 10.1093/gerona/glt090

DO - 10.1093/gerona/glt090

M3 - Journal article

C2 - 23788654

AN - SCOPUS:84896747719

SN - 1079-5006

VL - 69 A

SP - 274

EP - 281

JO - Journals of Gerontology. Series A: Biological Sciences & Medical Sciences

JF - Journals of Gerontology. Series A: Biological Sciences & Medical Sciences

IS - 3

ER -