Abstract
Cerebrovascular reactivity during hypocapnia was tested in 20 migraineurs (8 with aura, 12 without aura) and 30 sex- and age-matched healthy subjects, and during nitroglycerin-induced headache in 12 healthy subjects. Before and during hyperventilation, mean blood-flow velocity (Vmean) in the middle cerebral artery was measured with transcranial Doppler. In each subject a pCO2 reactivity index (RI) was calculated as (delta Vmean/baseline Vmean)/delta pCO2. Interictally, patients with migraine with aura showed higher RI (p < 0.05 ANOVA and multiple range test) than controls, whereas migraineurs without aura did not differ from healthy subjects. Ictal and interictal RIs were similar in 9 patients suffering from migraine without aura. No side-to-side differences were detected in RI. During nitroglycerin-induced headache, the RIs were no different from those recorded during migraine attacks and in non-nitroglycerin-provoked healthy controls (p > 0.05, ANOVA and multiple range test). The exaggerated response in migraine with aura might predispose for the characteristic changes in rCBF seen during attacks.
| Original language | English |
|---|---|
| Journal | Cephalalgia : an international journal of headache |
| Volume | 15 |
| Issue number | 3 |
| Pages (from-to) | 211-5 |
| Number of pages | 5 |
| ISSN | 0333-1024 |
| Publication status | Published - Jun 1995 |
Keywords
- Adult
- Analysis of Variance
- Cerebrovascular Circulation
- Female
- Humans
- Hyperventilation
- Hypocapnia
- Male
- Middle Aged
- Migraine Disorders
- Ultrasonography, Doppler, Transcranial