Increase in natural killer cell activity during diethylcarbamazine treatment of patients with filariasis

TY - JOUR

T1 - Increase in natural killer cell activity during diethylcarbamazine treatment of patients with filariasis

AU - Pedersen, B K

AU - Bygbjerg, Ib Christian

AU - Svenson, M

PY - 1987/9/1

Y1 - 1987/9/1

N2 - Two patients, one with Bancroftian filariasis and the other with onchocerciasis, and two healthy controls were treated with diethylcarbamazine (DEC). The natural killer (NK) cell activity of the two patients increased during DEC treatment to 2.5 and 2.8 times, respectively, while that of the controls remained unchanged. We conclude that the augmentation of baseline NK cell activity, as well as interferon- and interleukin-2-enhanced NK cell activity seen in the patients, is not a direct effect of DEC, but is related to the reaction to DEC in lymphatic filariasis and onchocerciasis.

AB - Two patients, one with Bancroftian filariasis and the other with onchocerciasis, and two healthy controls were treated with diethylcarbamazine (DEC). The natural killer (NK) cell activity of the two patients increased during DEC treatment to 2.5 and 2.8 times, respectively, while that of the controls remained unchanged. We conclude that the augmentation of baseline NK cell activity, as well as interferon- and interleukin-2-enhanced NK cell activity seen in the patients, is not a direct effect of DEC, but is related to the reaction to DEC in lymphatic filariasis and onchocerciasis.

KW - Adult

KW - Animals

KW - Diethylcarbamazine

KW - Elephantiasis, Filarial

KW - Female

KW - Filariasis

KW - Humans

KW - Killer Cells, Natural

KW - Male

KW - Middle Aged

KW - Onchocerciasis

M3 - Journal article

C2 - 2892372

SN - 0001-706X

VL - 44

SP - 353

EP - 355

JO - Acta Tropica

JF - Acta Tropica

IS - 3

ER -