Incidence rates and trends of hip/femur fractures in five European countries: comparison using e-healthcare records databases

G Requena; V Abbing-Karahagopian; C Huerta; M L De Bruin; Y Alvarez; M Miret; U Hesse; H Gardarsdottir; P C Souverein; J Slattery; C Schneider; M Rottenkolber; S Schmiedl; M Gil; M C H De Groot; A Bate; A Ruigómez; L A García Rodríguez; S Johansson; F de Vries; D Montero; R Schlienger; R Reynolds; O H Klungel; F J de Abajo

doi:10.1007/s00223-014-9850-y

Incidence rates and trends of hip/femur fractures in five European countries: comparison using e-healthcare records databases

G Requena, V Abbing-Karahagopian, C Huerta, M L De Bruin, Y Alvarez, M Miret, U Hesse, H Gardarsdottir, P C Souverein, J Slattery, C Schneider, M Rottenkolber, S Schmiedl, M Gil, M C H De Groot, A Bate, A Ruigómez, L A García Rodríguez, S Johansson, F de VriesD Montero, R Schlienger, R Reynolds, O H Klungel, F J de Abajo

35 Citations (Scopus)

Abstract

Hip fractures represent a major public health challenge worldwide. Multinational studies using a common methodology are scarce. We aimed to estimate the incidence rates (IRs) and trends of hip/femur fractures over the period 2003-2009 in five European countries. The study was performed using seven electronic health-care records databases (DBs) from Denmark, The Netherlands, Germany, Spain, and the United Kingdom, based on the same protocol. Yearly IRs of hip/femur fractures were calculated for the general population and for those aged ≥50 years. Trends over time were evaluated using linear regression analysis for both crude and standardized IRs. Sex- and age-standardized IRs for the UK, Netherlands, and Spanish DBs varied from 9 to 11 per 10,000 person-years for the general population and from 22 to 26 for those ≥50 years old; the German DB showed slightly higher IRs (about 13 and 30, respectively), whereas the Danish DB yielded IRs twofold higher (19 and 52, respectively). IRs increased exponentially with age in both sexes. The ratio of females to males was ≥2 for patients aged ≥70-79 years in most DBs. Statistically significant trends over time were only shown for the UK DB (CPRD) (+0.7% per year, P < 0.01) and the Danish DB (-1.4% per year, P < 0.01). IRs of hip/femur fractures varied greatly across European countries. With the exception of Denmark, no decreasing trend was observed over the study period.

Original language	English
Journal	Calcified Tissue International
Volume	94
Issue number	6
Pages (from-to)	580-9
Number of pages	10
ISSN	0171-967X
DOIs	https://doi.org/10.1007/s00223-014-9850-y
Publication status	Published - Jun 2014

Keywords

Adult
Age Distribution
Aged
Aged, 80 and over
Databases, Factual
Denmark
Electronic Health Records
Female
Femoral Neck Fractures
Germany
Great Britain
Hip Fractures
Humans
Incidence
Male
Middle Aged
Netherlands
Sex Distribution
Spain
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00223-014-9850-y

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Requena, G., Abbing-Karahagopian, V., Huerta, C., De Bruin, M. L., Alvarez, Y., Miret, M., Hesse, U., Gardarsdottir, H., Souverein, P. C., Slattery, J., Schneider, C., Rottenkolber, M., Schmiedl, S., Gil, M., De Groot, M. C. H., Bate, A., Ruigómez, A., García Rodríguez, L. A., Johansson, S., ... de Abajo, F. J. (2014). Incidence rates and trends of hip/femur fractures in five European countries: comparison using e-healthcare records databases. Calcified Tissue International, 94(6), 580-9. https://doi.org/10.1007/s00223-014-9850-y

Requena, G, Abbing-Karahagopian, V, Huerta, C, De Bruin, ML, Alvarez, Y, Miret, M, Hesse, U, Gardarsdottir, H, Souverein, PC, Slattery, J, Schneider, C, Rottenkolber, M, Schmiedl, S, Gil, M, De Groot, MCH, Bate, A, Ruigómez, A, García Rodríguez, LA, Johansson, S, de Vries, F, Montero, D, Schlienger, R, Reynolds, R, Klungel, OH & de Abajo, FJ 2014, 'Incidence rates and trends of hip/femur fractures in five European countries: comparison using e-healthcare records databases', Calcified Tissue International, vol. 94, no. 6, pp. 580-9. https://doi.org/10.1007/s00223-014-9850-y

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title = "Incidence rates and trends of hip/femur fractures in five European countries: comparison using e-healthcare records databases",

abstract = "Hip fractures represent a major public health challenge worldwide. Multinational studies using a common methodology are scarce. We aimed to estimate the incidence rates (IRs) and trends of hip/femur fractures over the period 2003-2009 in five European countries. The study was performed using seven electronic health-care records databases (DBs) from Denmark, The Netherlands, Germany, Spain, and the United Kingdom, based on the same protocol. Yearly IRs of hip/femur fractures were calculated for the general population and for those aged ≥50 years. Trends over time were evaluated using linear regression analysis for both crude and standardized IRs. Sex- and age-standardized IRs for the UK, Netherlands, and Spanish DBs varied from 9 to 11 per 10,000 person-years for the general population and from 22 to 26 for those ≥50 years old; the German DB showed slightly higher IRs (about 13 and 30, respectively), whereas the Danish DB yielded IRs twofold higher (19 and 52, respectively). IRs increased exponentially with age in both sexes. The ratio of females to males was ≥2 for patients aged ≥70-79 years in most DBs. Statistically significant trends over time were only shown for the UK DB (CPRD) (+0.7% per year, P < 0.01) and the Danish DB (-1.4% per year, P < 0.01). IRs of hip/femur fractures varied greatly across European countries. With the exception of Denmark, no decreasing trend was observed over the study period.",

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author = "G Requena and V Abbing-Karahagopian and C Huerta and {De Bruin}, {M L} and Y Alvarez and M Miret and U Hesse and H Gardarsdottir and Souverein, {P C} and J Slattery and C Schneider and M Rottenkolber and S Schmiedl and M Gil and {De Groot}, {M C H} and A Bate and A Ruig{\'o}mez and {Garc{\'i}a Rodr{\'i}guez}, {L A} and S Johansson and {de Vries}, F and D Montero and R Schlienger and R Reynolds and Klungel, {O H} and {de Abajo}, {F J}",

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T1 - Incidence rates and trends of hip/femur fractures in five European countries

T2 - comparison using e-healthcare records databases

AU - Requena, G

AU - Abbing-Karahagopian, V

AU - Huerta, C

AU - De Bruin, M L

AU - Alvarez, Y

AU - Miret, M

AU - Hesse, U

AU - Gardarsdottir, H

AU - Souverein, P C

AU - Slattery, J

AU - Schneider, C

AU - Rottenkolber, M

AU - Schmiedl, S

AU - Gil, M

AU - De Groot, M C H

AU - Bate, A

AU - Ruigómez, A

AU - García Rodríguez, L A

AU - Johansson, S

AU - de Vries, F

AU - Montero, D

AU - Schlienger, R

AU - Reynolds, R

AU - Klungel, O H

AU - de Abajo, F J

PY - 2014/6

Y1 - 2014/6

N2 - Hip fractures represent a major public health challenge worldwide. Multinational studies using a common methodology are scarce. We aimed to estimate the incidence rates (IRs) and trends of hip/femur fractures over the period 2003-2009 in five European countries. The study was performed using seven electronic health-care records databases (DBs) from Denmark, The Netherlands, Germany, Spain, and the United Kingdom, based on the same protocol. Yearly IRs of hip/femur fractures were calculated for the general population and for those aged ≥50 years. Trends over time were evaluated using linear regression analysis for both crude and standardized IRs. Sex- and age-standardized IRs for the UK, Netherlands, and Spanish DBs varied from 9 to 11 per 10,000 person-years for the general population and from 22 to 26 for those ≥50 years old; the German DB showed slightly higher IRs (about 13 and 30, respectively), whereas the Danish DB yielded IRs twofold higher (19 and 52, respectively). IRs increased exponentially with age in both sexes. The ratio of females to males was ≥2 for patients aged ≥70-79 years in most DBs. Statistically significant trends over time were only shown for the UK DB (CPRD) (+0.7% per year, P < 0.01) and the Danish DB (-1.4% per year, P < 0.01). IRs of hip/femur fractures varied greatly across European countries. With the exception of Denmark, no decreasing trend was observed over the study period.

AB - Hip fractures represent a major public health challenge worldwide. Multinational studies using a common methodology are scarce. We aimed to estimate the incidence rates (IRs) and trends of hip/femur fractures over the period 2003-2009 in five European countries. The study was performed using seven electronic health-care records databases (DBs) from Denmark, The Netherlands, Germany, Spain, and the United Kingdom, based on the same protocol. Yearly IRs of hip/femur fractures were calculated for the general population and for those aged ≥50 years. Trends over time were evaluated using linear regression analysis for both crude and standardized IRs. Sex- and age-standardized IRs for the UK, Netherlands, and Spanish DBs varied from 9 to 11 per 10,000 person-years for the general population and from 22 to 26 for those ≥50 years old; the German DB showed slightly higher IRs (about 13 and 30, respectively), whereas the Danish DB yielded IRs twofold higher (19 and 52, respectively). IRs increased exponentially with age in both sexes. The ratio of females to males was ≥2 for patients aged ≥70-79 years in most DBs. Statistically significant trends over time were only shown for the UK DB (CPRD) (+0.7% per year, P < 0.01) and the Danish DB (-1.4% per year, P < 0.01). IRs of hip/femur fractures varied greatly across European countries. With the exception of Denmark, no decreasing trend was observed over the study period.

KW - Adult

KW - Age Distribution

KW - Aged

KW - Aged, 80 and over

KW - Databases, Factual

KW - Denmark

KW - Electronic Health Records

KW - Female

KW - Femoral Neck Fractures

KW - Germany

KW - Great Britain

KW - Hip Fractures

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Netherlands

KW - Sex Distribution

KW - Spain

KW - Comparative Study

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1007/s00223-014-9850-y

DO - 10.1007/s00223-014-9850-y

M3 - Journal article

C2 - 24687523

SN - 0171-967X

VL - 94

SP - 580

EP - 589

JO - Calcified Tissue International

JF - Calcified Tissue International

IS - 6

ER -

Incidence rates and trends of hip/femur fractures in five European countries: comparison using e-healthcare records databases

Abstract

Keywords

UN SDGs

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