TY - JOUR
T1 - Incidence of head and neck cancer in children
T2 - A Danish nationwide study from 1978 to 2014
AU - Grønhøj, Christian
AU - Hjalgrim, Lisa
AU - Jakobsen, Kathrine K
AU - Charabi, Birgitte
AU - Mirian, Christian
AU - Laier, Gunnar H
AU - Kiss, Katalin
AU - Rechnitzer, Catherine
AU - Friborg, Jeppe
AU - von Buchwald, Christian
AU - Hjuler, Thomas
N1 - © 2018 Wiley Periodicals, Inc.
PY - 2018/7
Y1 - 2018/7
N2 - Background: Pediatric head and neck malignancies are rare and only a few descriptive epidemiological studies have been published. Using unique nationwide registries, we report age-specific incidence rates of head and neck cancer (HNC) among children during four decades. Methods: Data were obtained from the Danish Cancer Registry. We included children aged 0–14 years diagnosed between January 1, 1978 and December 31, 2014 with extra-orbital, nonskin and nonbone HNC. Patients were divided into nine groups in regard to tumor location: oral cavity, oropharynx, nasopharynx, hypopharynx, thyroid, major salivary glands, larynx, and middle ear. Based on the World Health Organization standard population and Danish age-specific population counts, age-adjusted incidence rates (AAIR) and average annual percentage change (AAPC) were calculated and examined for trends. Results: In total, 169 children (55.6% females) were registered with a malignant tumor in the head and neck region. The AAIR increased with an AAPC of 2.2% (95% CI, 0.8–3.7%). Females showed an AAIR of 0.54 per 100,000 person years compared to that of males, with 0.41 per 100,000 person years (P < 0.01). The AAIR was higher among children aged 10–14 years compared to 0–9-year-old children (P < 0.01). Based on morphology, a significant increase in AAIR was observed for sarcomas, with an increase of 0.16–0.27 per 100,000 person years (P < 0.05). Conclusions: The incidence rate of pediatric HNC was higher among females and evidence of increasing rates was observed during 1978–2014, explained by an increase mainly in sarcomas.
AB - Background: Pediatric head and neck malignancies are rare and only a few descriptive epidemiological studies have been published. Using unique nationwide registries, we report age-specific incidence rates of head and neck cancer (HNC) among children during four decades. Methods: Data were obtained from the Danish Cancer Registry. We included children aged 0–14 years diagnosed between January 1, 1978 and December 31, 2014 with extra-orbital, nonskin and nonbone HNC. Patients were divided into nine groups in regard to tumor location: oral cavity, oropharynx, nasopharynx, hypopharynx, thyroid, major salivary glands, larynx, and middle ear. Based on the World Health Organization standard population and Danish age-specific population counts, age-adjusted incidence rates (AAIR) and average annual percentage change (AAPC) were calculated and examined for trends. Results: In total, 169 children (55.6% females) were registered with a malignant tumor in the head and neck region. The AAIR increased with an AAPC of 2.2% (95% CI, 0.8–3.7%). Females showed an AAIR of 0.54 per 100,000 person years compared to that of males, with 0.41 per 100,000 person years (P < 0.01). The AAIR was higher among children aged 10–14 years compared to 0–9-year-old children (P < 0.01). Based on morphology, a significant increase in AAIR was observed for sarcomas, with an increase of 0.16–0.27 per 100,000 person years (P < 0.05). Conclusions: The incidence rate of pediatric HNC was higher among females and evidence of increasing rates was observed during 1978–2014, explained by an increase mainly in sarcomas.
U2 - 10.1002/pbc.27037
DO - 10.1002/pbc.27037
M3 - Journal article
C2 - 29603576
SN - 1545-5009
VL - 65
JO - Pediatric Blood and Cancer
JF - Pediatric Blood and Cancer
IS - 7
M1 - e27037
ER -
