Incidence of HACEK bacteraemia in Denmark: A 6-year population-based study

Lisbeth Lützen; Bente Olesen; Marianne Voldstedlund; Jens J Christensen; Claus Moser; Jenny D Knudsen; Kurt Fuursted; Gitte N Hartmeyer; Ming Chen; Turid S Søndergaard; Flemming S Rosenvinge; Esad Dzajic; Henrik C Schønheyder; Niels Nørskov-Lauritsen

doi:10.1016/j.ijid.2018.01.025

Incidence of HACEK bacteraemia in Denmark: A 6-year population-based study

Lisbeth Lützen, Bente Olesen, Marianne Voldstedlund, Jens J Christensen, Claus Moser, Jenny D Knudsen, Kurt Fuursted, Gitte N Hartmeyer, Ming Chen, Turid S Søndergaard, Flemming S Rosenvinge, Esad Dzajic, Henrik C Schønheyder, Niels Nørskov-Lauritsen

Department of Clinical Medicine

12 Citations (Scopus)

24 Downloads (Pure)

Abstract

OBJECTIVES: Bacteria with common microbiological and clinical characteristics are often recognized as a particular group. The acronym HACEK stands for five fastidious genera associated with infective endocarditis (Haemophilus, Aggregatibacter, Cardiobacterium, Eikenella, and Kingella). Data on the epidemiology of HACEK are sparse. This article reports a 6-year nationwide study of HACEK bacteraemia in Denmark.

METHODS: Cases of HACEK bacteraemia occurring during the years 2010-2015 were retrieved from the national Danish microbiology database, covering an average surveillance population of 5.6 million per year.

RESULTS: A total of 147 cases of HACEK bacteraemia were identified, corresponding to an annual incidence of 0.44 per 100000 population. The annual incidence for males was 0.56 per 100000 and for females was 0.31 per 100000. The median age was 56 years (range 0-97 years), with variation among the genera. One hundred and forty-three isolates were identified to the species level and six to the genus level: Haemophilus spp, n=55; Aggregatibacter spp, n=37; Cardiobacterium spp, n=9; Eikenella corrodens n=21; and Kingella spp, n=27.

CONCLUSIONS: This is the first study on the incidence of HACEK bacteraemia in a large surveillance population and may inspire further studies on the HACEK group. Haemophilus spp other than Haemophilus influenzae accounted for most cases of HACEK bacteraemia in Denmark, with Aggregatibacter spp in second place.

Original language	English
Journal	International Journal of Infectious Diseases
Volume	68
Pages (from-to)	83-87
ISSN	1201-9712
DOIs	https://doi.org/10.1016/j.ijid.2018.01.025
Publication status	Published - Mar 2018

Keywords

Adolescent
Adult
Aged
Aged, 80 and over
Aggregatibacter
Bacteremia/diagnosis
Cardiobacterium
Child
Child, Preschool
Denmark/epidemiology
Eikenella corrodens
Endocarditis, Bacterial/diagnosis
Female
Haemophilus
Humans
Incidence
Infant
Kingella
Male
Middle Aged
Retrospective Studies
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Young Adult

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10.1016/j.ijid.2018.01.025Licence: CC BY-NC-ND

1-s2.0-S1201971218300262Final published version, 545 KBLicence: CC BY-NC-ND

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Lützen, L., Olesen, B., Voldstedlund, M., Christensen, J. J., Moser, C., Knudsen, J. D., Fuursted, K., Hartmeyer, G. N., Chen, M., Søndergaard, T. S., Rosenvinge, F. S., Dzajic, E., Schønheyder, H. C., & Nørskov-Lauritsen, N. (2018). Incidence of HACEK bacteraemia in Denmark: A 6-year population-based study. International Journal of Infectious Diseases, 68, 83-87. https://doi.org/10.1016/j.ijid.2018.01.025

Lützen, L, Olesen, B, Voldstedlund, M, Christensen, JJ, Moser, C, Knudsen, JD, Fuursted, K, Hartmeyer, GN, Chen, M, Søndergaard, TS, Rosenvinge, FS, Dzajic, E, Schønheyder, HC & Nørskov-Lauritsen, N 2018, 'Incidence of HACEK bacteraemia in Denmark: A 6-year population-based study', International Journal of Infectious Diseases, vol. 68, pp. 83-87. https://doi.org/10.1016/j.ijid.2018.01.025

@article{ff8067f689e340e9ad6fdee065864493,

title = "Incidence of HACEK bacteraemia in Denmark: A 6-year population-based study",

abstract = "OBJECTIVES: Bacteria with common microbiological and clinical characteristics are often recognized as a particular group. The acronym HACEK stands for five fastidious genera associated with infective endocarditis (Haemophilus, Aggregatibacter, Cardiobacterium, Eikenella, and Kingella). Data on the epidemiology of HACEK are sparse. This article reports a 6-year nationwide study of HACEK bacteraemia in Denmark.METHODS: Cases of HACEK bacteraemia occurring during the years 2010-2015 were retrieved from the national Danish microbiology database, covering an average surveillance population of 5.6 million per year.RESULTS: A total of 147 cases of HACEK bacteraemia were identified, corresponding to an annual incidence of 0.44 per 100000 population. The annual incidence for males was 0.56 per 100000 and for females was 0.31 per 100000. The median age was 56 years (range 0-97 years), with variation among the genera. One hundred and forty-three isolates were identified to the species level and six to the genus level: Haemophilus spp, n=55; Aggregatibacter spp, n=37; Cardiobacterium spp, n=9; Eikenella corrodens n=21; and Kingella spp, n=27.CONCLUSIONS: This is the first study on the incidence of HACEK bacteraemia in a large surveillance population and may inspire further studies on the HACEK group. Haemophilus spp other than Haemophilus influenzae accounted for most cases of HACEK bacteraemia in Denmark, with Aggregatibacter spp in second place.",

keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Aggregatibacter, Bacteremia/diagnosis, Cardiobacterium, Child, Child, Preschool, Denmark/epidemiology, Eikenella corrodens, Endocarditis, Bacterial/diagnosis, Female, Haemophilus, Humans, Incidence, Infant, Kingella, Male, Middle Aged, Retrospective Studies, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Young Adult",

author = "Lisbeth L{\"u}tzen and Bente Olesen and Marianne Voldstedlund and Christensen, {Jens J} and Claus Moser and Knudsen, {Jenny D} and Kurt Fuursted and Hartmeyer, {Gitte N} and Ming Chen and S{\o}ndergaard, {Turid S} and Rosenvinge, {Flemming S} and Esad Dzajic and Sch{\o}nheyder, {Henrik C} and Niels N{\o}rskov-Lauritsen",

year = "2018",

month = mar,

doi = "10.1016/j.ijid.2018.01.025",

language = "English",

volume = "68",

pages = "83--87",

journal = "International Journal of Infectious Diseases",

issn = "1201-9712",

publisher = "Elsevier",

}

TY - JOUR

T1 - Incidence of HACEK bacteraemia in Denmark

T2 - A 6-year population-based study

AU - Lützen, Lisbeth

AU - Olesen, Bente

AU - Voldstedlund, Marianne

AU - Christensen, Jens J

AU - Moser, Claus

AU - Knudsen, Jenny D

AU - Fuursted, Kurt

AU - Hartmeyer, Gitte N

AU - Chen, Ming

AU - Søndergaard, Turid S

AU - Rosenvinge, Flemming S

AU - Dzajic, Esad

AU - Schønheyder, Henrik C

AU - Nørskov-Lauritsen, Niels

PY - 2018/3

Y1 - 2018/3

N2 - OBJECTIVES: Bacteria with common microbiological and clinical characteristics are often recognized as a particular group. The acronym HACEK stands for five fastidious genera associated with infective endocarditis (Haemophilus, Aggregatibacter, Cardiobacterium, Eikenella, and Kingella). Data on the epidemiology of HACEK are sparse. This article reports a 6-year nationwide study of HACEK bacteraemia in Denmark.METHODS: Cases of HACEK bacteraemia occurring during the years 2010-2015 were retrieved from the national Danish microbiology database, covering an average surveillance population of 5.6 million per year.RESULTS: A total of 147 cases of HACEK bacteraemia were identified, corresponding to an annual incidence of 0.44 per 100000 population. The annual incidence for males was 0.56 per 100000 and for females was 0.31 per 100000. The median age was 56 years (range 0-97 years), with variation among the genera. One hundred and forty-three isolates were identified to the species level and six to the genus level: Haemophilus spp, n=55; Aggregatibacter spp, n=37; Cardiobacterium spp, n=9; Eikenella corrodens n=21; and Kingella spp, n=27.CONCLUSIONS: This is the first study on the incidence of HACEK bacteraemia in a large surveillance population and may inspire further studies on the HACEK group. Haemophilus spp other than Haemophilus influenzae accounted for most cases of HACEK bacteraemia in Denmark, with Aggregatibacter spp in second place.

AB - OBJECTIVES: Bacteria with common microbiological and clinical characteristics are often recognized as a particular group. The acronym HACEK stands for five fastidious genera associated with infective endocarditis (Haemophilus, Aggregatibacter, Cardiobacterium, Eikenella, and Kingella). Data on the epidemiology of HACEK are sparse. This article reports a 6-year nationwide study of HACEK bacteraemia in Denmark.METHODS: Cases of HACEK bacteraemia occurring during the years 2010-2015 were retrieved from the national Danish microbiology database, covering an average surveillance population of 5.6 million per year.RESULTS: A total of 147 cases of HACEK bacteraemia were identified, corresponding to an annual incidence of 0.44 per 100000 population. The annual incidence for males was 0.56 per 100000 and for females was 0.31 per 100000. The median age was 56 years (range 0-97 years), with variation among the genera. One hundred and forty-three isolates were identified to the species level and six to the genus level: Haemophilus spp, n=55; Aggregatibacter spp, n=37; Cardiobacterium spp, n=9; Eikenella corrodens n=21; and Kingella spp, n=27.CONCLUSIONS: This is the first study on the incidence of HACEK bacteraemia in a large surveillance population and may inspire further studies on the HACEK group. Haemophilus spp other than Haemophilus influenzae accounted for most cases of HACEK bacteraemia in Denmark, with Aggregatibacter spp in second place.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Aggregatibacter

KW - Bacteremia/diagnosis

KW - Cardiobacterium

KW - Child

KW - Child, Preschool

KW - Denmark/epidemiology

KW - Eikenella corrodens

KW - Endocarditis, Bacterial/diagnosis

KW - Female

KW - Haemophilus

KW - Humans

KW - Incidence

KW - Infant

KW - Kingella

KW - Male

KW - Middle Aged

KW - Retrospective Studies

KW - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

KW - Young Adult

U2 - 10.1016/j.ijid.2018.01.025

DO - 10.1016/j.ijid.2018.01.025

M3 - Journal article

C2 - 29408674

SN - 1201-9712

VL - 68

SP - 83

EP - 87

JO - International Journal of Infectious Diseases

JF - International Journal of Infectious Diseases

ER -

Incidence of HACEK bacteraemia in Denmark: A 6-year population-based study

Abstract

Keywords

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