Incidence of childhood central nervous system tumors in the Nordic countries

Lisbeth Samsø Schmidt; Kjeld Schmiegelow; Päivi Lähteenmäki; C Träger; T Stokland; Kathrine Grell; G Gustafson; Astrid Sehested; Ole Raashou-Nielsen; Christoffer Johansen; J. Schuz

Incidence of childhood central nervous system tumors in the Nordic countries

Lisbeth Samsø Schmidt, Kjeld Schmiegelow, Päivi Lähteenmäki, C Träger, T Stokland, Kathrine Grell, G Gustafson, Astrid Sehested, Ole Raashou-Nielsen, Christoffer Johansen, J. Schuz

Section of Biostatistics

34 Citations (Scopus)

Abstract

Background: The incidence rates of childhood central nervous system (CNS) tumors in the Nordic countries remain among the highest in the world. Large geographical and temporal variations in the incidence rates of CNS tumors have been reported. Increasing incidence rates would be a public health concern, as they might indicate increased exposure to environmental risk factors. Methods: All 3,983 children 0-14 years of age registered with a primary CNS tumor in 1985-2006 in the national cancer registries of the Denmark, Finland, Norway, and Sweden were identified. Tumors were classified according to the International Classification of Childhood Cancer version 3 (ICCC-3). Join-point analysis was used to detect changes in trends and to estimate annual changes in incidence rates. Results: The mean annual incidence rate of CNS tumors was 42 per million. No statistically significant change in time trends of incidence rates was observed during 1985-2006. Furthermore, the incidence by birth cohort was relatively stable during the study period. Conclusion: The incidence rates of childhood CNS tumors in the Nordic countries remain among the highest in the world. The stable incidence rates during the last 22 years indicate that major changes in environmental risk factors are unlikely.

Original language	English
Journal	Pediatric Blood & Cancer
Volume	56
Issue number	1
Pages (from-to)	65
Number of pages	69
ISSN	1545-5009
Publication status	Published - Jan 2011

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title = "Incidence of childhood central nervous system tumors in the Nordic countries",

abstract = "Background: The incidence rates of childhood central nervous system (CNS) tumors in the Nordic countries remain among the highest in the world. Large geographical and temporal variations in the incidence rates of CNS tumors have been reported. Increasing incidence rates would be a public health concern, as they might indicate increased exposure to environmental risk factors. Methods: All 3,983 children 0-14 years of age registered with a primary CNS tumor in 1985-2006 in the national cancer registries of the Denmark, Finland, Norway, and Sweden were identified. Tumors were classified according to the International Classification of Childhood Cancer version 3 (ICCC-3). Join-point analysis was used to detect changes in trends and to estimate annual changes in incidence rates. Results: The mean annual incidence rate of CNS tumors was 42 per million. No statistically significant change in time trends of incidence rates was observed during 1985-2006. Furthermore, the incidence by birth cohort was relatively stable during the study period. Conclusion: The incidence rates of childhood CNS tumors in the Nordic countries remain among the highest in the world. The stable incidence rates during the last 22 years indicate that major changes in environmental risk factors are unlikely.",

author = "Schmidt, {Lisbeth Sams{\o}} and Kjeld Schmiegelow and P{\"a}ivi L{\"a}hteenm{\"a}ki and C Tr{\"a}ger and T Stokland and Kathrine Grell and G Gustafson and Astrid Sehested and Ole Raashou-Nielsen and Christoffer Johansen and J. Schuz",

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T1 - Incidence of childhood central nervous system tumors in the Nordic countries

AU - Schmidt, Lisbeth Samsø

AU - Schmiegelow, Kjeld

AU - Lähteenmäki, Päivi

AU - Träger, C

AU - Stokland, T

AU - Grell, Kathrine

AU - Gustafson, G

AU - Sehested, Astrid

AU - Raashou-Nielsen, Ole

AU - Johansen, Christoffer

AU - Schuz, J.

PY - 2011/1

Y1 - 2011/1

N2 - Background: The incidence rates of childhood central nervous system (CNS) tumors in the Nordic countries remain among the highest in the world. Large geographical and temporal variations in the incidence rates of CNS tumors have been reported. Increasing incidence rates would be a public health concern, as they might indicate increased exposure to environmental risk factors. Methods: All 3,983 children 0-14 years of age registered with a primary CNS tumor in 1985-2006 in the national cancer registries of the Denmark, Finland, Norway, and Sweden were identified. Tumors were classified according to the International Classification of Childhood Cancer version 3 (ICCC-3). Join-point analysis was used to detect changes in trends and to estimate annual changes in incidence rates. Results: The mean annual incidence rate of CNS tumors was 42 per million. No statistically significant change in time trends of incidence rates was observed during 1985-2006. Furthermore, the incidence by birth cohort was relatively stable during the study period. Conclusion: The incidence rates of childhood CNS tumors in the Nordic countries remain among the highest in the world. The stable incidence rates during the last 22 years indicate that major changes in environmental risk factors are unlikely.

AB - Background: The incidence rates of childhood central nervous system (CNS) tumors in the Nordic countries remain among the highest in the world. Large geographical and temporal variations in the incidence rates of CNS tumors have been reported. Increasing incidence rates would be a public health concern, as they might indicate increased exposure to environmental risk factors. Methods: All 3,983 children 0-14 years of age registered with a primary CNS tumor in 1985-2006 in the national cancer registries of the Denmark, Finland, Norway, and Sweden were identified. Tumors were classified according to the International Classification of Childhood Cancer version 3 (ICCC-3). Join-point analysis was used to detect changes in trends and to estimate annual changes in incidence rates. Results: The mean annual incidence rate of CNS tumors was 42 per million. No statistically significant change in time trends of incidence rates was observed during 1985-2006. Furthermore, the incidence by birth cohort was relatively stable during the study period. Conclusion: The incidence rates of childhood CNS tumors in the Nordic countries remain among the highest in the world. The stable incidence rates during the last 22 years indicate that major changes in environmental risk factors are unlikely.

M3 - Journal article

SN - 1545-5009

VL - 56

SP - 65

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

IS - 1

ER -

Incidence of childhood central nervous system tumors in the Nordic countries

Abstract

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