In Vivo Radionuclide Generators for Diagnostics and Therapy

Patricia E Edem; Jesper Fonslet; Andreas Kjær; Matthias Herth; Gregory Severin

doi:10.1155/2016/6148357

In Vivo Radionuclide Generators for Diagnostics and Therapy

Patricia E Edem, Jesper Fonslet, Andreas Kjær, Matthias Herth, Gregory Severin

Endocrinology and Metabolism

13 Citations (Scopus)

Abstract

In vivo radionuclide generators make complex combinations of physical and chemical properties available for medical diagnostics and therapy. Perhaps the best-known in vivo generator is ²¹²Pb/²¹²Bi, which takes advantage of the extended half-life of ²¹²Pb to execute a targeted delivery of the therapeutic short-lived -emitter ²¹²Bi. Often, as in the case of ⁸¹Rb/⁸¹Kr, chemical changes resulting from the transmutation of the parent are relied upon for diagnostic value. In other instances such as with extended alpha decay chains, chemical changes may lead to unwanted consequences. This article reviews some common and not-so-common in vivo generators with the purpose of understanding their value in medicine and medical research. This is currently relevant in light of a recent push for alpha emitters in targeted therapies, which often come with extended decay chains.

Original language	English
Article number	6148357
Journal	Bioinorganic Chemistry and Applications
Volume	2016
Pages (from-to)	1-9
Number of pages	9
ISSN	1565-3633
DOIs	https://doi.org/10.1155/2016/6148357
Publication status	Published - 2016

Access to Document

10.1155/2016/6148357Licence: CC BY

Cite this

@article{d9a9755546c240b888145943a92d27f1,

title = "In Vivo Radionuclide Generators for Diagnostics and Therapy",

abstract = "In vivo radionuclide generators make complex combinations of physical and chemical properties available for medical diagnostics and therapy. Perhaps the best-known in vivo generator is 212Pb/212Bi, which takes advantage of the extended half-life of 212Pb to execute a targeted delivery of the therapeutic short-lived -emitter 212Bi. Often, as in the case of 81Rb/81Kr, chemical changes resulting from the transmutation of the parent are relied upon for diagnostic value. In other instances such as with extended alpha decay chains, chemical changes may lead to unwanted consequences. This article reviews some common and not-so-common in vivo generators with the purpose of understanding their value in medicine and medical research. This is currently relevant in light of a recent push for alpha emitters in targeted therapies, which often come with extended decay chains.",

author = "Edem, {Patricia E} and Jesper Fonslet and Andreas Kj{\ae}r and Matthias Herth and Gregory Severin",

year = "2016",

doi = "10.1155/2016/6148357",

language = "English",

volume = "2016",

pages = "1--9",

journal = "Bioinorganic Chemistry and Applications",

issn = "1565-3633",

publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - In Vivo Radionuclide Generators for Diagnostics and Therapy

AU - Edem, Patricia E

AU - Fonslet, Jesper

AU - Kjær, Andreas

AU - Herth, Matthias

AU - Severin, Gregory

PY - 2016

Y1 - 2016

N2 - In vivo radionuclide generators make complex combinations of physical and chemical properties available for medical diagnostics and therapy. Perhaps the best-known in vivo generator is 212Pb/212Bi, which takes advantage of the extended half-life of 212Pb to execute a targeted delivery of the therapeutic short-lived -emitter 212Bi. Often, as in the case of 81Rb/81Kr, chemical changes resulting from the transmutation of the parent are relied upon for diagnostic value. In other instances such as with extended alpha decay chains, chemical changes may lead to unwanted consequences. This article reviews some common and not-so-common in vivo generators with the purpose of understanding their value in medicine and medical research. This is currently relevant in light of a recent push for alpha emitters in targeted therapies, which often come with extended decay chains.

AB - In vivo radionuclide generators make complex combinations of physical and chemical properties available for medical diagnostics and therapy. Perhaps the best-known in vivo generator is 212Pb/212Bi, which takes advantage of the extended half-life of 212Pb to execute a targeted delivery of the therapeutic short-lived -emitter 212Bi. Often, as in the case of 81Rb/81Kr, chemical changes resulting from the transmutation of the parent are relied upon for diagnostic value. In other instances such as with extended alpha decay chains, chemical changes may lead to unwanted consequences. This article reviews some common and not-so-common in vivo generators with the purpose of understanding their value in medicine and medical research. This is currently relevant in light of a recent push for alpha emitters in targeted therapies, which often come with extended decay chains.

U2 - 10.1155/2016/6148357

DO - 10.1155/2016/6148357

M3 - Journal article

C2 - 28058040

SN - 1565-3633

VL - 2016

SP - 1

EP - 9

JO - Bioinorganic Chemistry and Applications

JF - Bioinorganic Chemistry and Applications

M1 - 6148357

ER -

In Vivo Radionuclide Generators for Diagnostics and Therapy

Abstract

Access to Document

Fingerprint

Cite this