In Vitro-Produced Pancreas Organogenesis Models In Three Dimensions: Self-Organization From Few Stem Cells Or Progenitors

TY - JOUR

T1 - In Vitro-Produced Pancreas Organogenesis Models In Three Dimensions

T2 - Self-Organization From Few Stem Cells Or Progenitors

AU - Greggio, Chiara

AU - De Franceschi, Filippo

AU - Grapin-Botton, Anne

N1 - Copyright © 2014 AlphaMed Press.

PY - 2015/1

Y1 - 2015/1

N2 - Three dimensional models of organ biogenesis have recently flourished. They promote a balance between stem/progenitor cell expansion and differentiation without the constraints of flat tissue culture vessels, allowing for autonomous self-organization of cells. Such models allow the formation of miniature organs in a dish and are emerging for the pancreas, starting from embryonic progenitors and adult cells. This review focusses on the currently available systems and how these allow new types of questions to be addressed. We discuss the expected advancements including their potential to study human pancreas development and function as well as to develop diabetes models and therapeutic cells. Stem Cells 2014.

AB - Three dimensional models of organ biogenesis have recently flourished. They promote a balance between stem/progenitor cell expansion and differentiation without the constraints of flat tissue culture vessels, allowing for autonomous self-organization of cells. Such models allow the formation of miniature organs in a dish and are emerging for the pancreas, starting from embryonic progenitors and adult cells. This review focusses on the currently available systems and how these allow new types of questions to be addressed. We discuss the expected advancements including their potential to study human pancreas development and function as well as to develop diabetes models and therapeutic cells. Stem Cells 2014.

U2 - 10.1002/stem.1828

DO - 10.1002/stem.1828

M3 - Review

C2 - 25185771

SN - 1066-5099

VL - 33

SP - 8

EP - 14

JO - Stem Cells

JF - Stem Cells

IS - 1

ER -