In Vitro Maturation and Culture of Human Oocytes

Jennifer R. Gruhn, Stine Gry Kristensen, Claus Yding Andersen, Eva R. Hoffmann*

*Corresponding author for this work
2 Citations (Scopus)

Abstract

We describe the collection, culture, and ex vivo, in vitro maturation of germinal vesicle (GV) oocytes obtained from human small antral follicles (hSAFs). hSAFs contain fully grown GV oocytes and have the advantages that they are more numerous than large or mature follicles, which are used in IVF treatment. hSAFs can be obtained directly from human ovarian tissue without exogenous gonadotrophin stimulation and therefore allows studies of oocytes even from young women and girls. The method described here was developed to study human female meiosis but could in theory also be used for fertility treatment.

Original languageEnglish
Title of host publicationMouse Oocyte Development : Methods and Protocols
EditorsMarie-Hélène Verlhac, Marie-Emilie Terret
Number of pages8
PublisherHumana Press
Publication date2018
Pages23-30
ISBN (Print)978-1-4939-8602-6
ISBN (Electronic)978-1-4939-8603-3
DOIs
Publication statusPublished - 2018
SeriesMethods in Molecular Biology
Volume1818
ISSN1064-3745

Keywords

  • Aneuploidy
  • Cumulus oocyte complex
  • Germinal vesicle
  • Human small antral follicles
  • In vitro maturation
  • Meiosis
  • Metaphase II

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