In vitro evaluation of the effects of graphene platelets on glioblastoma multiforme cells

TY - JOUR

T1 - In vitro evaluation of the effects of graphene platelets on glioblastoma multiforme cells

AU - Jaworski, Slawomir

AU - Sawosz, Ewa

AU - Grodzik, Marta

AU - Winnicka, Anna

AU - Prasek, Marta

AU - Wierzbicki, Mateusz

AU - Chwalibog, André

PY - 2013/1/23

Y1 - 2013/1/23

N2 - Graphene is a single atom-thick material with exciting potential. It can be used in many fields, from electronics to biomedicine. However, little is known about its toxicity and biocompatibility. Herein, we report a study on the toxicity of graphene platelets (GPs) by examining the influence of GPs on the morphology, mortality, viability, membrane integrity, and type of cell death of U87 and U118 glioma cells. It was found that graphene is toxic to glioma cells, but it activated apoptosis only in the U118 cell line, without inducing necrosis, indicating the potential applicability of GP in anticancer therapy.

AB - Graphene is a single atom-thick material with exciting potential. It can be used in many fields, from electronics to biomedicine. However, little is known about its toxicity and biocompatibility. Herein, we report a study on the toxicity of graphene platelets (GPs) by examining the influence of GPs on the morphology, mortality, viability, membrane integrity, and type of cell death of U87 and U118 glioma cells. It was found that graphene is toxic to glioma cells, but it activated apoptosis only in the U118 cell line, without inducing necrosis, indicating the potential applicability of GP in anticancer therapy.

U2 - 10.2147/IJN.S39456

DO - 10.2147/IJN.S39456

M3 - Journal article

C2 - 23378763

SN - 1176-9114

VL - 8

SP - 413

EP - 420

JO - International Journal of Nanomedicine

JF - International Journal of Nanomedicine

IS - 1

ER -