Improved skeletal muscle mass and strength after heavy strength training in very old individuals

Rasmus Leidesdorff Bechshøft; Nikolaj Mølkjær Malmgaard-Clausen; Bjørn Gliese; Nina Beyer; Abigail L. Mackey; Jesper Løvind Andersen; Michael Kjær; Lars Holm

doi:10.1016/j.exger.2017.03.014

Improved skeletal muscle mass and strength after heavy strength training in very old individuals

Rasmus Leidesdorff Bechshøft, Nikolaj Mølkjær Malmgaard-Clausen, Bjørn Gliese, Nina Beyer, Abigail L. Mackey, Jesper Løvind Andersen, Michael Kjær, Lars Holm

22 Citations (Scopus)

Abstract

Age-related loss of muscle mass and function represents personal and socioeconomic challenges. The purpose of this study was to determine the adaptation of skeletal musculature in very old individuals (83 + years) performing 12 weeks of heavy resistance training (3 ×/week) (HRT) compared to a non-training control group (CON). Both groups received similar protein supplementations. We studied 26 participants (86.9 ± 3.2 (SD) (83–94, range) years old) per-protocol. Quadriceps cross-sectional area (CSA) differed between groups at post-test (P < 0.05) and increased 1.5 ± 0.7 cm² (3.4%) (P < 0.05) in HRT only. The relative increase in CSA correlated inversely with the baseline level of CSA (R² = 0.43, P < 0.02). Thigh muscle isometric strength, isokinetic peak torque and power increased significantly only in HRT by 10–15%, whereas knee extension one-repetition maximum (1 RM) improved by 91%. Physical functional tests, muscle fiber type distribution and size did not differ significantly between groups. We conclude that in protein supplemented very old individuals, heavy resistance training can increase muscle mass and strength, and that the relative improvement in mass is more pronounced when initial muscle mass is low.

Original language	English
Journal	Experimental Gerontology
Volume	92
Pages (from-to)	96-105
Number of pages	10
ISSN	0531-5565
DOIs	https://doi.org/10.1016/j.exger.2017.03.014
Publication status	Published - 1 Jun 2017

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10.1016/j.exger.2017.03.014

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title = "Improved skeletal muscle mass and strength after heavy strength training in very old individuals",

abstract = "Age-related loss of muscle mass and function represents personal and socioeconomic challenges. The purpose of this study was to determine the adaptation of skeletal musculature in very old individuals (83 + years) performing 12 weeks of heavy resistance training (3 ×/week) (HRT) compared to a non-training control group (CON). Both groups received similar protein supplementations. We studied 26 participants (86.9 ± 3.2 (SD) (83–94, range) years old) per-protocol. Quadriceps cross-sectional area (CSA) differed between groups at post-test (P < 0.05) and increased 1.5 ± 0.7 cm2 (3.4%) (P < 0.05) in HRT only. The relative increase in CSA correlated inversely with the baseline level of CSA (R2 = 0.43, P < 0.02). Thigh muscle isometric strength, isokinetic peak torque and power increased significantly only in HRT by 10–15%, whereas knee extension one-repetition maximum (1 RM) improved by 91%. Physical functional tests, muscle fiber type distribution and size did not differ significantly between groups. We conclude that in protein supplemented very old individuals, heavy resistance training can increase muscle mass and strength, and that the relative improvement in mass is more pronounced when initial muscle mass is low.",

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AU - Bechshøft, Rasmus Leidesdorff

AU - Malmgaard-Clausen, Nikolaj Mølkjær

AU - Gliese, Bjørn

AU - Beyer, Nina

AU - Mackey, Abigail L.

AU - Andersen, Jesper Løvind

AU - Kjær, Michael

AU - Holm, Lars

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Age-related loss of muscle mass and function represents personal and socioeconomic challenges. The purpose of this study was to determine the adaptation of skeletal musculature in very old individuals (83 + years) performing 12 weeks of heavy resistance training (3 ×/week) (HRT) compared to a non-training control group (CON). Both groups received similar protein supplementations. We studied 26 participants (86.9 ± 3.2 (SD) (83–94, range) years old) per-protocol. Quadriceps cross-sectional area (CSA) differed between groups at post-test (P < 0.05) and increased 1.5 ± 0.7 cm2 (3.4%) (P < 0.05) in HRT only. The relative increase in CSA correlated inversely with the baseline level of CSA (R2 = 0.43, P < 0.02). Thigh muscle isometric strength, isokinetic peak torque and power increased significantly only in HRT by 10–15%, whereas knee extension one-repetition maximum (1 RM) improved by 91%. Physical functional tests, muscle fiber type distribution and size did not differ significantly between groups. We conclude that in protein supplemented very old individuals, heavy resistance training can increase muscle mass and strength, and that the relative improvement in mass is more pronounced when initial muscle mass is low.

AB - Age-related loss of muscle mass and function represents personal and socioeconomic challenges. The purpose of this study was to determine the adaptation of skeletal musculature in very old individuals (83 + years) performing 12 weeks of heavy resistance training (3 ×/week) (HRT) compared to a non-training control group (CON). Both groups received similar protein supplementations. We studied 26 participants (86.9 ± 3.2 (SD) (83–94, range) years old) per-protocol. Quadriceps cross-sectional area (CSA) differed between groups at post-test (P < 0.05) and increased 1.5 ± 0.7 cm2 (3.4%) (P < 0.05) in HRT only. The relative increase in CSA correlated inversely with the baseline level of CSA (R2 = 0.43, P < 0.02). Thigh muscle isometric strength, isokinetic peak torque and power increased significantly only in HRT by 10–15%, whereas knee extension one-repetition maximum (1 RM) improved by 91%. Physical functional tests, muscle fiber type distribution and size did not differ significantly between groups. We conclude that in protein supplemented very old individuals, heavy resistance training can increase muscle mass and strength, and that the relative improvement in mass is more pronounced when initial muscle mass is low.

U2 - 10.1016/j.exger.2017.03.014

DO - 10.1016/j.exger.2017.03.014

M3 - Journal article

C2 - 28363433

SN - 0531-5565

VL - 92

SP - 96

EP - 105

JO - Experimental Gerontology

JF - Experimental Gerontology

ER -

Improved skeletal muscle mass and strength after heavy strength training in very old individuals

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