Abstract
OBJECTIVE: To evaluate if there is a performance difference in the combined screening for trisomy 21 between the double tests performed before and after 10 + 0 weeks of gestation.
METHODS: The study included all 97 trisomy 21 cases from January 2004 to December 2007, in a screening program where the double test was measured in week 8 + 0 to 13 + 6 and the nuchal translucency in week 11 + 3 to 13 + 6.
RESULTS: As many as 87 of the 97 cases were diagnosed in the screening program (detection rate = 90%). Among the 53 cases having the double test taken before 10 + 0 weeks, no cases were missed [detection rate (DR) = 100%, CI = 0.94-1.00] and among the 44 having the double test taken after 10 + 0 weeks, 10 cases were missed (DR = 77%, CI = 0.65-0.90). This difference in DR was highly significant (P = 0.0009). No difference was observed between false positive rates or median maternal age of the two groups.
CONCLUSION: A significantly higher DR was obtained when the double test was taken early in pregnancy (<10 + 0 weeks), than when it was taken later (>or=10 + 0 weeks). The results could not be explained by a difference in either the false positive rate or the maternal age between the two groups.
| Original language | English |
|---|---|
| Journal | Prenatal Diagnosis |
| Volume | 28 |
| Issue number | 9 |
| Pages (from-to) | 839-844 |
| ISSN | 0197-3851 |
| DOIs | |
| Publication status | Published - 2008 |
| Externally published | Yes |
Keywords
- Adult
- Chorionic Gonadotropin, beta Subunit, Human/blood
- Down Syndrome/diagnosis
- False Negative Reactions
- False Positive Reactions
- Female
- Gestational Age
- Humans
- Middle Aged
- Pregnancy
- Pregnancy Trimester, First
- Pregnancy-Associated Plasma Protein-A/analysis
- Ultrasonography, Prenatal
- Young Adult