Improved gait in persons with knee related mobility limitations by a rosehip food supplement: A randomized, double-blind, placebo-controlled trial

TY - JOUR

T1 - Improved gait in persons with knee related mobility limitations by a rosehip food supplement

T2 - A randomized, double-blind, placebo-controlled trial

AU - Ginnerup-Nielsen, Elisabeth

AU - Christensen, Robin

AU - Bliddal, Henning

AU - Zangger, Graziella

AU - Hansen, Lisbeth

AU - Henriksen, Marius

N1 - Copyright © 2015 Elsevier B.V. All rights reserved.

PY - 2015/9/1

Y1 - 2015/9/1

N2 - PURPOSE: To evaluate the efficacy of a specialized rosehip powder nutraceutical on the biomechanical function of the knee joint during walking in individuals with knee-related walking limitations.METHODS: Randomized, participant and outcome assessor blinded trial. Participants with self-reported knee-related walking limitations were randomized (1:1) to receive three capsules/day of either rosehip powder or identically appearing placebo capsules for 12 weeks. At baseline and the 12 weeks follow-up, 3-dimensional gait analyses were performed from which the peak resultant knee moment was selected as primary outcome. Secondary outcomes included sagittal and frontal plane knee joint moments, knee joint kinematics, peaks in the vertical ground reaction forces, and self-selected walking speeds. Analyses were based on ANCOVA with the 'Intention-To-Treat' (ITT) population, defined as all randomized participants using last observation carried forward imputation for missing data.RESULTS: 100 participants were randomized to rosehip (n=50) or placebo (n=50) and defined the ITT population. Of these 94 completed the study (47 in each group). There were statistically significant group differences in the change from baseline in the primary outcome: the resultant knee moment (0.06 nm/kg, 95%CI: 0.00-0.12; P=0.039) and in the peaks in the sagittal plane moments and kinematics during the stance phase of walking with the rosehip group exhibiting greater joint moments and more knee joint flexion during walking than the placebo group.CONCLUSION: A daily intake of rosehip powder for 12 weeks improved important indices of knee joint function and dynamics during walking compared to placebo in persons with knee-related walking limitations.

AB - PURPOSE: To evaluate the efficacy of a specialized rosehip powder nutraceutical on the biomechanical function of the knee joint during walking in individuals with knee-related walking limitations.METHODS: Randomized, participant and outcome assessor blinded trial. Participants with self-reported knee-related walking limitations were randomized (1:1) to receive three capsules/day of either rosehip powder or identically appearing placebo capsules for 12 weeks. At baseline and the 12 weeks follow-up, 3-dimensional gait analyses were performed from which the peak resultant knee moment was selected as primary outcome. Secondary outcomes included sagittal and frontal plane knee joint moments, knee joint kinematics, peaks in the vertical ground reaction forces, and self-selected walking speeds. Analyses were based on ANCOVA with the 'Intention-To-Treat' (ITT) population, defined as all randomized participants using last observation carried forward imputation for missing data.RESULTS: 100 participants were randomized to rosehip (n=50) or placebo (n=50) and defined the ITT population. Of these 94 completed the study (47 in each group). There were statistically significant group differences in the change from baseline in the primary outcome: the resultant knee moment (0.06 nm/kg, 95%CI: 0.00-0.12; P=0.039) and in the peaks in the sagittal plane moments and kinematics during the stance phase of walking with the rosehip group exhibiting greater joint moments and more knee joint flexion during walking than the placebo group.CONCLUSION: A daily intake of rosehip powder for 12 weeks improved important indices of knee joint function and dynamics during walking compared to placebo in persons with knee-related walking limitations.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Biomechanical Phenomena

KW - Dietary Supplements

KW - Double-Blind Method

KW - Female

KW - Follow-Up Studies

KW - Gait

KW - Humans

KW - Knee Joint

KW - Male

KW - Middle Aged

KW - Mobility Limitation

KW - Phytotherapy

KW - Plant Preparations

KW - Rosa

KW - Self Report

KW - Treatment Outcome

KW - Walking

U2 - 10.1016/j.gaitpost.2015.07.001

DO - 10.1016/j.gaitpost.2015.07.001

M3 - Journal article

C2 - 26234471

SN - 0966-6362

VL - 42

SP - 340

EP - 347

JO - Gait and Posture

JF - Gait and Posture

IS - 3

ER -