Importance of the fat content within the cheese-matrix for blood lipid profile, faecal fat excretion, and gut microbiome in growing pigs

Tanja Kongerslev Thorning; Anne Raben; Nathalie Tommerup Bendsen; Henry Johs. Høgh Jørgensen; Pia Kiilerich; Ylva Margareta Ardö; Janne Kunchel Lorenzen; Karsten Kristiansen; Arne Astrup

doi:10.1016/j.idairyj.2016.04.006

Importance of the fat content within the cheese-matrix for blood lipid profile, faecal fat excretion, and gut microbiome in growing pigs

Tanja Kongerslev Thorning^*, Anne Raben, Nathalie Tommerup Bendsen, Henry Johs. Høgh Jørgensen, Pia Kiilerich, Ylva Margareta Ardö, Janne Kunchel Lorenzen, Karsten Kristiansen, Arne Astrup

^*Corresponding author for this work

7 Citations (Scopus)

Abstract

Cheese and butter have been shown to affect blood lipids differently. This parallel-arm, randomised, controlled study in 36 crossbred growing sows compared the effect of diets with either regular-fat cheese (REG), reduced-fat cheese + butter (RED) or butter (BUT) on blood lipids, faecal fat and energy excretion and gut microbiome in pigs. A 14-d run-in period was followed by 14-d interventions with macronutrient-matched diets. Fasting total cholesterol and HDL-cholesterol after 14 days were higher in REG compared with BUT, but only tended to be higher in RED. Compared with BUT, REG and RED had higher faecal fat excretion. Faecal energy excretion was only higher in REG, and this correlated with a lower microbiome Firmicutes-to-Bacteroidetes ratio. In conclusion, dairy fat consumed as cheese or butter caused different metabolic effects. Differences between reduced-fat cheese+butter and butter were less pronounced than differences between regular-fat cheese and butter, suggesting an impact of the dairy-matrix.

Original language	English
Journal	International Dairy Journal
Volume	61
Pages (from-to)	67-75
Number of pages	9
ISSN	0958-6946
DOIs	https://doi.org/10.1016/j.idairyj.2016.04.006
Publication status	Published - 2016

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Thorning, T. K., Raben, A., Bendsen, N. T., Jørgensen, H. J. H., Kiilerich, P., Ardö, Y. M., Lorenzen, J. K., Kristiansen, K., & Astrup, A. (2016). Importance of the fat content within the cheese-matrix for blood lipid profile, faecal fat excretion, and gut microbiome in growing pigs. International Dairy Journal, 61, 67-75. https://doi.org/10.1016/j.idairyj.2016.04.006

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title = "Importance of the fat content within the cheese-matrix for blood lipid profile, faecal fat excretion, and gut microbiome in growing pigs",

abstract = "Cheese and butter have been shown to affect blood lipids differently. This parallel-arm, randomised, controlled study in 36 crossbred growing sows compared the effect of diets with either regular-fat cheese (REG), reduced-fat cheese + butter (RED) or butter (BUT) on blood lipids, faecal fat and energy excretion and gut microbiome in pigs. A 14-d run-in period was followed by 14-d interventions with macronutrient-matched diets. Fasting total cholesterol and HDL-cholesterol after 14 days were higher in REG compared with BUT, but only tended to be higher in RED. Compared with BUT, REG and RED had higher faecal fat excretion. Faecal energy excretion was only higher in REG, and this correlated with a lower microbiome Firmicutes-to-Bacteroidetes ratio. In conclusion, dairy fat consumed as cheese or butter caused different metabolic effects. Differences between reduced-fat cheese+butter and butter were less pronounced than differences between regular-fat cheese and butter, suggesting an impact of the dairy-matrix.",

author = "Thorning, {Tanja Kongerslev} and Anne Raben and Bendsen, {Nathalie Tommerup} and J{\o}rgensen, {Henry Johs. H{\o}gh} and Pia Kiilerich and Ard{\"o}, {Ylva Margareta} and Lorenzen, {Janne Kunchel} and Karsten Kristiansen and Arne Astrup",

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AU - Thorning, Tanja Kongerslev

AU - Raben, Anne

AU - Bendsen, Nathalie Tommerup

AU - Jørgensen, Henry Johs. Høgh

AU - Kiilerich, Pia

AU - Ardö, Ylva Margareta

AU - Lorenzen, Janne Kunchel

AU - Kristiansen, Karsten

AU - Astrup, Arne

N1 - CURIS 2016 NEXS 273

PY - 2016

Y1 - 2016

N2 - Cheese and butter have been shown to affect blood lipids differently. This parallel-arm, randomised, controlled study in 36 crossbred growing sows compared the effect of diets with either regular-fat cheese (REG), reduced-fat cheese + butter (RED) or butter (BUT) on blood lipids, faecal fat and energy excretion and gut microbiome in pigs. A 14-d run-in period was followed by 14-d interventions with macronutrient-matched diets. Fasting total cholesterol and HDL-cholesterol after 14 days were higher in REG compared with BUT, but only tended to be higher in RED. Compared with BUT, REG and RED had higher faecal fat excretion. Faecal energy excretion was only higher in REG, and this correlated with a lower microbiome Firmicutes-to-Bacteroidetes ratio. In conclusion, dairy fat consumed as cheese or butter caused different metabolic effects. Differences between reduced-fat cheese+butter and butter were less pronounced than differences between regular-fat cheese and butter, suggesting an impact of the dairy-matrix.

AB - Cheese and butter have been shown to affect blood lipids differently. This parallel-arm, randomised, controlled study in 36 crossbred growing sows compared the effect of diets with either regular-fat cheese (REG), reduced-fat cheese + butter (RED) or butter (BUT) on blood lipids, faecal fat and energy excretion and gut microbiome in pigs. A 14-d run-in period was followed by 14-d interventions with macronutrient-matched diets. Fasting total cholesterol and HDL-cholesterol after 14 days were higher in REG compared with BUT, but only tended to be higher in RED. Compared with BUT, REG and RED had higher faecal fat excretion. Faecal energy excretion was only higher in REG, and this correlated with a lower microbiome Firmicutes-to-Bacteroidetes ratio. In conclusion, dairy fat consumed as cheese or butter caused different metabolic effects. Differences between reduced-fat cheese+butter and butter were less pronounced than differences between regular-fat cheese and butter, suggesting an impact of the dairy-matrix.

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DO - 10.1016/j.idairyj.2016.04.006

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SN - 0958-6946

VL - 61

SP - 67

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JO - International Dairy Journal

JF - International Dairy Journal

ER -

Importance of the fat content within the cheese-matrix for blood lipid profile, faecal fat excretion, and gut microbiome in growing pigs

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