Impaired transmission in the corticospinal tract and gait disability in spinal cord injured persons

Dorothy Barthélemy; Maria Willerslev-Olsen; Henrik Lundell; Bernard A. Conway; Hanne Knudsen; Fin Biering-Sørensen; Jens Bo Nielsen; Dorothy Barthélemy; Maria Willerslev-Olsen; Hans Magnus Henrik Lundell; Bernard A Conway; Hanne Knudsen; Fin Biering-Sørensen; Jens Bo Holm-Nielsen

doi:10.1152/jn.00382.2010

Impaired transmission in the corticospinal tract and gait disability in spinal cord injured persons

Dorothy Barthélemy, Maria Willerslev-Olsen, Henrik Lundell, Bernard A. Conway, Hanne Knudsen, Fin Biering-Sørensen, Jens Bo Nielsen, Dorothy Barthélemy, Maria Willerslev-Olsen, Hans Magnus Henrik Lundell, Bernard A Conway, Hanne Knudsen, Fin Biering-Sørensen, Jens Bo Holm-Nielsen

61 Citations (Scopus)

Abstract

Rehabilitation following spinal cord injury is likely to depend on recovery of corticospinal systems. Here we investigate whether transmission in the corticospinal tract may explain foot drop (inability to dorsiflex ankle) in persons with spinal cord lesion. The study was performed in 24 persons with incomplete spinal cord lesion (C1 to L1) and 15 healthy controls. Coherence in the 10- to 20-Hz frequency band between paired tibialis anterior muscle (TA) electromyographic recordings obtained in the swing phase of walking, which was taken as a measure of motor unit synchronization. It was significantly correlated with the degree of foot drop, as measured by toe elevation and ankle angle excursion in the first part of swing. Transcranial magnetic stimulation was used to elicit motor-evoked potentials (MEPs) in the TA. The amplitude of the MEPs at rest and their latency during contraction were correlated to the degree of foot drop. Spinal cord injured participants who exhibited a large foot drop had little or no MEP at rest in the TA muscle and had little or no coherence in the same muscle during walking. Gait speed was correlated to foot drop, and was the lowest in participants with no MEP at rest. The data confirm that transmission in the corticospinal tract is of importance for lifting the foot during the swing phase of human gait.

Original language	English
Journal	Journal of Neurophysiology
Volume	104
Issue number	2
Pages (from-to)	1167-76
Number of pages	10
ISSN	0022-3077
DOIs	https://doi.org/10.1152/jn.00382.2010 https://doi.org/10.1152/jn.00382.2010
Publication status	Published - 1 Aug 2010

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Barthélemy, D., Willerslev-Olsen, M., Lundell, H., Conway, B. A., Knudsen, H., Biering-Sørensen, F., Nielsen, J. B., Barthélemy, D., Willerslev-Olsen, M., Lundell, H. M. H., Conway, B. A., Knudsen, H., Biering-Sørensen, F., & Holm-Nielsen, J. B. (2010). Impaired transmission in the corticospinal tract and gait disability in spinal cord injured persons. Journal of Neurophysiology, 104(2), 1167-76. https://doi.org/10.1152/jn.00382.2010, https://doi.org/10.1152/jn.00382.2010

Barthélemy, D, Willerslev-Olsen, M, Lundell, H, Conway, BA, Knudsen, H, Biering-Sørensen, F , Nielsen, JB, Barthélemy, D, Willerslev-Olsen, M, Lundell, HMH, Conway, BA, Knudsen, H, Biering-Sørensen, F & Holm-Nielsen, JB 2010, 'Impaired transmission in the corticospinal tract and gait disability in spinal cord injured persons', Journal of Neurophysiology, vol. 104, no. 2, pp. 1167-76. https://doi.org/10.1152/jn.00382.2010, https://doi.org/10.1152/jn.00382.2010

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abstract = "Rehabilitation following spinal cord injury is likely to depend on recovery of corticospinal systems. Here we investigate whether transmission in the corticospinal tract may explain foot drop (inability to dorsiflex ankle) in persons with spinal cord lesion. The study was performed in 24 persons with incomplete spinal cord lesion (C1 to L1) and 15 healthy controls. Coherence in the 10- to 20-Hz frequency band between paired tibialis anterior muscle (TA) electromyographic recordings obtained in the swing phase of walking, which was taken as a measure of motor unit synchronization. It was significantly correlated with the degree of foot drop, as measured by toe elevation and ankle angle excursion in the first part of swing. Transcranial magnetic stimulation was used to elicit motor-evoked potentials (MEPs) in the TA. The amplitude of the MEPs at rest and their latency during contraction were correlated to the degree of foot drop. Spinal cord injured participants who exhibited a large foot drop had little or no MEP at rest in the TA muscle and had little or no coherence in the same muscle during walking. Gait speed was correlated to foot drop, and was the lowest in participants with no MEP at rest. The data confirm that transmission in the corticospinal tract is of importance for lifting the foot during the swing phase of human gait.",

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AU - Biering-Sørensen, Fin

AU - Nielsen, Jens Bo

AU - Barthélemy, Dorothy

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N2 - Rehabilitation following spinal cord injury is likely to depend on recovery of corticospinal systems. Here we investigate whether transmission in the corticospinal tract may explain foot drop (inability to dorsiflex ankle) in persons with spinal cord lesion. The study was performed in 24 persons with incomplete spinal cord lesion (C1 to L1) and 15 healthy controls. Coherence in the 10- to 20-Hz frequency band between paired tibialis anterior muscle (TA) electromyographic recordings obtained in the swing phase of walking, which was taken as a measure of motor unit synchronization. It was significantly correlated with the degree of foot drop, as measured by toe elevation and ankle angle excursion in the first part of swing. Transcranial magnetic stimulation was used to elicit motor-evoked potentials (MEPs) in the TA. The amplitude of the MEPs at rest and their latency during contraction were correlated to the degree of foot drop. Spinal cord injured participants who exhibited a large foot drop had little or no MEP at rest in the TA muscle and had little or no coherence in the same muscle during walking. Gait speed was correlated to foot drop, and was the lowest in participants with no MEP at rest. The data confirm that transmission in the corticospinal tract is of importance for lifting the foot during the swing phase of human gait.

AB - Rehabilitation following spinal cord injury is likely to depend on recovery of corticospinal systems. Here we investigate whether transmission in the corticospinal tract may explain foot drop (inability to dorsiflex ankle) in persons with spinal cord lesion. The study was performed in 24 persons with incomplete spinal cord lesion (C1 to L1) and 15 healthy controls. Coherence in the 10- to 20-Hz frequency band between paired tibialis anterior muscle (TA) electromyographic recordings obtained in the swing phase of walking, which was taken as a measure of motor unit synchronization. It was significantly correlated with the degree of foot drop, as measured by toe elevation and ankle angle excursion in the first part of swing. Transcranial magnetic stimulation was used to elicit motor-evoked potentials (MEPs) in the TA. The amplitude of the MEPs at rest and their latency during contraction were correlated to the degree of foot drop. Spinal cord injured participants who exhibited a large foot drop had little or no MEP at rest in the TA muscle and had little or no coherence in the same muscle during walking. Gait speed was correlated to foot drop, and was the lowest in participants with no MEP at rest. The data confirm that transmission in the corticospinal tract is of importance for lifting the foot during the swing phase of human gait.

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Impaired transmission in the corticospinal tract and gait disability in spinal cord injured persons

Abstract

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