Impaired formation of vasodilators in peripheral tissue in essential hypertension is normalized by exercise training: role of adenosine and prostacyclin

Ylva Hellsten; Lasse Gliemann Jensen; Pia Thaning; Michael Permin Nyberg; Stefan Peter Mortensen

doi:10.1097/HJH.0b013e328356dd57

Impaired formation of vasodilators in peripheral tissue in essential hypertension is normalized by exercise training: role of adenosine and prostacyclin

Ylva Hellsten, Lasse Gliemann Jensen, Pia Thaning, Michael Permin Nyberg, Stefan Peter Mortensen

29 Citations (Scopus)

Abstract

OBJECTIVES: This study examined vascular function and the adenosine system in skeletal muscle of patients diagnosed with essential hypertension (n=10) and of normotensive (n=11) patients, before and after aerobic training. METHODS: Before and after 8 weeks of aerobic training, the patients completed experiments in which leg blood flow was determined during infusion of adenosine, acetylcholine and during exercise (20W); muscle interstitial fluid and femoral venous plasma were sampled via microdialysis probes during baseline conditions, exercise and adenosine infusion and resting muscle biopsies were obtained from muscle vastus lateralis. RESULTS: Before training, leg vascular conductance in response to arterial adenosine infusion was similar in the hypertensive and normotensive groups and the individual vascular response was positively correlated to that of both acetylcholine infusion (r =0.66, P<0.001) and exercise (r =0.72, P<0.001). Before training, interstitial adenosine concentrations during exercise and prostacyclin (PGI2) concentrations after adenosine infusion were lower in the hypertensive than the normotensive group (P<0.05). In the hypertensive group, training did not affect the vasodilatory response to arterially infused adenosine but increased the formation of interstitial adenosine and PGI2 and lowered blood pressure. In the normotensive group, training resulted in lower (P<0.05) leg vascular conductance in response to arterial adenosine infusion. CONCLUSION: The present data suggest that essential hypertension is associated with a reduced capacity to form adenosine and PGI2 at the skeletal muscle microcirculatory level, which is likely to contribute to the increased peripheral vascular resistance related to the disease. This impairment in vasodilator formation can be normalized by aerobic training.

Original language	English
Journal	Journal of Hypertension
Volume	30
Issue number	10
Pages (from-to)	2007-2014
Number of pages	8
ISSN	0263-6352
DOIs	https://doi.org/10.1097/HJH.0b013e328356dd57
Publication status	Published - Oct 2012

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Impaired formation of vasodilators in peripheral tissue in essential hypertension is normalized by exercise training: role of adenosine and prostacyclin. / Hellsten, Ylva ; Jensen, Lasse Gliemann; Thaning, Pia et al.
In: Journal of Hypertension, Vol. 30, No. 10, 10.2012, p. 2007-2014.

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title = "Impaired formation of vasodilators in peripheral tissue in essential hypertension is normalized by exercise training: role of adenosine and prostacyclin",

abstract = "OBJECTIVES: This study examined vascular function and the adenosine system in skeletal muscle of patients diagnosed with essential hypertension (n=10) and of normotensive (n=11) patients, before and after aerobic training. METHODS: Before and after 8 weeks of aerobic training, the patients completed experiments in which leg blood flow was determined during infusion of adenosine, acetylcholine and during exercise (20W); muscle interstitial fluid and femoral venous plasma were sampled via microdialysis probes during baseline conditions, exercise and adenosine infusion and resting muscle biopsies were obtained from muscle vastus lateralis. RESULTS: Before training, leg vascular conductance in response to arterial adenosine infusion was similar in the hypertensive and normotensive groups and the individual vascular response was positively correlated to that of both acetylcholine infusion (r =0.66, P<0.001) and exercise (r =0.72, P<0.001). Before training, interstitial adenosine concentrations during exercise and prostacyclin (PGI2) concentrations after adenosine infusion were lower in the hypertensive than the normotensive group (P<0.05). In the hypertensive group, training did not affect the vasodilatory response to arterially infused adenosine but increased the formation of interstitial adenosine and PGI2 and lowered blood pressure. In the normotensive group, training resulted in lower (P<0.05) leg vascular conductance in response to arterial adenosine infusion. CONCLUSION: The present data suggest that essential hypertension is associated with a reduced capacity to form adenosine and PGI2 at the skeletal muscle microcirculatory level, which is likely to contribute to the increased peripheral vascular resistance related to the disease. This impairment in vasodilator formation can be normalized by aerobic training.",

author = "Ylva Hellsten and Jensen, {Lasse Gliemann} and Pia Thaning and Nyberg, {Michael Permin} and Mortensen, {Stefan Peter}",

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T1 - Impaired formation of vasodilators in peripheral tissue in essential hypertension is normalized by exercise training

T2 - role of adenosine and prostacyclin

AU - Hellsten, Ylva

AU - Jensen, Lasse Gliemann

AU - Thaning, Pia

AU - Nyberg, Michael Permin

AU - Mortensen, Stefan Peter

N1 - CURIS 2012 5200 114

PY - 2012/10

Y1 - 2012/10

N2 - OBJECTIVES: This study examined vascular function and the adenosine system in skeletal muscle of patients diagnosed with essential hypertension (n=10) and of normotensive (n=11) patients, before and after aerobic training. METHODS: Before and after 8 weeks of aerobic training, the patients completed experiments in which leg blood flow was determined during infusion of adenosine, acetylcholine and during exercise (20W); muscle interstitial fluid and femoral venous plasma were sampled via microdialysis probes during baseline conditions, exercise and adenosine infusion and resting muscle biopsies were obtained from muscle vastus lateralis. RESULTS: Before training, leg vascular conductance in response to arterial adenosine infusion was similar in the hypertensive and normotensive groups and the individual vascular response was positively correlated to that of both acetylcholine infusion (r =0.66, P<0.001) and exercise (r =0.72, P<0.001). Before training, interstitial adenosine concentrations during exercise and prostacyclin (PGI2) concentrations after adenosine infusion were lower in the hypertensive than the normotensive group (P<0.05). In the hypertensive group, training did not affect the vasodilatory response to arterially infused adenosine but increased the formation of interstitial adenosine and PGI2 and lowered blood pressure. In the normotensive group, training resulted in lower (P<0.05) leg vascular conductance in response to arterial adenosine infusion. CONCLUSION: The present data suggest that essential hypertension is associated with a reduced capacity to form adenosine and PGI2 at the skeletal muscle microcirculatory level, which is likely to contribute to the increased peripheral vascular resistance related to the disease. This impairment in vasodilator formation can be normalized by aerobic training.

AB - OBJECTIVES: This study examined vascular function and the adenosine system in skeletal muscle of patients diagnosed with essential hypertension (n=10) and of normotensive (n=11) patients, before and after aerobic training. METHODS: Before and after 8 weeks of aerobic training, the patients completed experiments in which leg blood flow was determined during infusion of adenosine, acetylcholine and during exercise (20W); muscle interstitial fluid and femoral venous plasma were sampled via microdialysis probes during baseline conditions, exercise and adenosine infusion and resting muscle biopsies were obtained from muscle vastus lateralis. RESULTS: Before training, leg vascular conductance in response to arterial adenosine infusion was similar in the hypertensive and normotensive groups and the individual vascular response was positively correlated to that of both acetylcholine infusion (r =0.66, P<0.001) and exercise (r =0.72, P<0.001). Before training, interstitial adenosine concentrations during exercise and prostacyclin (PGI2) concentrations after adenosine infusion were lower in the hypertensive than the normotensive group (P<0.05). In the hypertensive group, training did not affect the vasodilatory response to arterially infused adenosine but increased the formation of interstitial adenosine and PGI2 and lowered blood pressure. In the normotensive group, training resulted in lower (P<0.05) leg vascular conductance in response to arterial adenosine infusion. CONCLUSION: The present data suggest that essential hypertension is associated with a reduced capacity to form adenosine and PGI2 at the skeletal muscle microcirculatory level, which is likely to contribute to the increased peripheral vascular resistance related to the disease. This impairment in vasodilator formation can be normalized by aerobic training.

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M3 - Journal article

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SP - 2007

EP - 2014

JO - Journal of Hypertension

JF - Journal of Hypertension

IS - 10

ER -

Impaired formation of vasodilators in peripheral tissue in essential hypertension is normalized by exercise training: role of adenosine and prostacyclin

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