Impact of Maternal Diet on Offspring Bone Fracture Risk During Childhood

TY - BOOK

T1 - Impact of Maternal Diet on Offspring Bone Fracture Risk During Childhood

AU - Petersen, Sesilje Elise Bondo

N1 - CURIS 2015 NEXS 112

PY - 2014

Y1 - 2014

N2 - Fetal programming is an emerging concept that links environmental conditions during embryonic and fetal development with risk of diseases later in life. A hypothesis for fetal programming of bone health state that peak bone mass may be modified by environmental influences during fetal life, including maternal diet and vitamin D status. However, few studies have investigated whether these factors during pregnancy impact offspring bone health in short as well as in the long term.The overall objective of this thesis was to investigate epidemiologically whether maternal vitamin D status and dietary patterns in two prospective pregnancy cohorts, were associated with offspring risk of bone fractures in childhood.Overall, our studies provided limited support to the hypothesis that fetal bone health is programmed by the maternal vitamin D status and overall diet during pregnancy. However, there were some indications of an increased risk for fractures when the mother consumed a Western diet and had high consumption of artificially sweetened soft drinks. Further, our results indicated that mid-pregnancy use of dietary supplements with high doses of vitamin D increased the risk for offspring fractures.

AB - Fetal programming is an emerging concept that links environmental conditions during embryonic and fetal development with risk of diseases later in life. A hypothesis for fetal programming of bone health state that peak bone mass may be modified by environmental influences during fetal life, including maternal diet and vitamin D status. However, few studies have investigated whether these factors during pregnancy impact offspring bone health in short as well as in the long term.The overall objective of this thesis was to investigate epidemiologically whether maternal vitamin D status and dietary patterns in two prospective pregnancy cohorts, were associated with offspring risk of bone fractures in childhood.Overall, our studies provided limited support to the hypothesis that fetal bone health is programmed by the maternal vitamin D status and overall diet during pregnancy. However, there were some indications of an increased risk for fractures when the mother consumed a Western diet and had high consumption of artificially sweetened soft drinks. Further, our results indicated that mid-pregnancy use of dietary supplements with high doses of vitamin D increased the risk for offspring fractures.

UR - https://rex.kb.dk/primo-explore/fulldisplay?docid=KGL01009082590&context=L&vid=NUI&search_scope=KGL&isFrbr=true&tab=default_tab&lang=da_DK

M3 - Ph.D. thesis

SN - 978-87-89148-27-4

BT - Impact of Maternal Diet on Offspring Bone Fracture Risk During Childhood

PB - Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen

CY - Copenhagen

ER -