TY - JOUR
T1 - Impact of dietary exposure to food contaminants on the risk of Parkinson's disease
AU - Petersen, Maria Skaalum
AU - Halling, Jónrit
AU - Bech, Sára
AU - Wermuth, Lene
AU - Weihe, Pál
AU - Nielsen, Flemming
AU - Jørgensen, Poul J
AU - Budtz-Jørgensen, Esben
AU - Grandjean, Philippe
N1 - Keywords: Aged; Aged, 80 and over; Case-Control Studies; Confidence Intervals; Diet; Environmental Exposure; Female; Food Contamination; Humans; Male; Neurologic Examination; Occupational Diseases; Odds Ratio; Parkinson Disease; Risk; Sex Factors
PY - 2008
Y1 - 2008
N2 - This study aimed to investigate the association of Parkinson's disease (PD) with dietary exposure to polychlorinated biphenyls (PCBs) and methylmercury (MeHg) in a community with increased exposure levels. A total of 79 clinically verified idiopathic PD cases and 154 controls matched by sex and age were examined in this case-control study in the Faroe Islands. Blood and hair samples were collected and a questionnaire recorded lifetime information on residence, dietary habits, smoking history, and occupational exposure to solvents, pesticides, and metals. Both unconditional and conditional logistic regression analyses were used to estimate the odds ratio (OR) and 95% confidence interval (CI) in regard to relevant exposure variables. Increased ORs for dietary intakes of whale meat and blubber during adult life were statistically significant. The ORs for occupational exposure to solvents, pesticides and metals also suggested an increased risk for PD. Current serum concentrations of summation operator PCB and related contaminants suggested slightly increased ORs, although only beta-hexachlorocyclohexane (beta-HCH) was statistically significant. Increased intake of whale meat and blubber in adult life was significantly associated with PD, thus suggesting a positive association between previous exposure to marine food contaminants and development of PD.
AB - This study aimed to investigate the association of Parkinson's disease (PD) with dietary exposure to polychlorinated biphenyls (PCBs) and methylmercury (MeHg) in a community with increased exposure levels. A total of 79 clinically verified idiopathic PD cases and 154 controls matched by sex and age were examined in this case-control study in the Faroe Islands. Blood and hair samples were collected and a questionnaire recorded lifetime information on residence, dietary habits, smoking history, and occupational exposure to solvents, pesticides, and metals. Both unconditional and conditional logistic regression analyses were used to estimate the odds ratio (OR) and 95% confidence interval (CI) in regard to relevant exposure variables. Increased ORs for dietary intakes of whale meat and blubber during adult life were statistically significant. The ORs for occupational exposure to solvents, pesticides and metals also suggested an increased risk for PD. Current serum concentrations of summation operator PCB and related contaminants suggested slightly increased ORs, although only beta-hexachlorocyclohexane (beta-HCH) was statistically significant. Increased intake of whale meat and blubber in adult life was significantly associated with PD, thus suggesting a positive association between previous exposure to marine food contaminants and development of PD.
U2 - 10.1016/j.neuro.2008.03.001
DO - 10.1016/j.neuro.2008.03.001
M3 - Journal article
C2 - 18455239
SN - 0161-813X
VL - 29
SP - 584
EP - 590
JO - NeuroToxicology
JF - NeuroToxicology
IS - 4
ER -
