Immunolymphoscintigraphy for metastatic sentinel nodes: test of a model

A H Chakera; B S Nielsen; J Madsen; J Romer; P E G Kristjansen; I Buch; Tina Binderup; C Ingvar; A Nalla; A Kjaer; B Hesse; A H Chakera; Boye S. Nielsen; J Madsen; John Rømer; Paul Ejnar Gremaud Kristjansen; I Buch; T Binderup; C Ingvar; Amarnadh Nalla; Andreas Kjær; B Hesse

doi:10.1155/2011/828151

Immunolymphoscintigraphy for metastatic sentinel nodes: test of a model

A H Chakera, B S Nielsen, J Madsen, J Romer, P E G Kristjansen, I Buch, Tina Binderup, C Ingvar, A Nalla, A Kjaer, B Hesse, A H Chakera, Boye S. Nielsen, J Madsen, John Rømer, Paul Ejnar Gremaud Kristjansen, I Buch, T Binderup, C Ingvar, Amarnadh NallaAndreas Kjær, B Hesse

Endocrinology and Metabolism

Abstract

Aim. To develop a method and obtain proof-of-principle for immunolymphoscintigraphy for identification of metastatic sentinel nodes. Methods. We selected one of four tumour-specific antibodies against human breast cancer and investigated (1), in immune-deficient (nude) mice with xenograft human breast cancer expressing the antigen if specific binding of the intratumorally injected, radioactively labelled, monoclonal antibody could be scintigraphically visualized, and (2) transportation to and retention in regional lymph nodes of the radioactively labelled antibody after subcutaneous injection in healthy rabbits. Results and Conclusion. Our paper suggests the theoretical possibility of a model of dual isotope immuno-lymphoscintigraphy for noninvasive, preoperative, malignant sentinel node imaging.

Original language	English
Journal	International Journal of Molecular Imaging
Volume	2011
Pages (from-to)	828151
Number of pages	7
ISSN	2090-1712
DOIs	https://doi.org/10.1155/2011/828151 https://doi.org/10.1155/2011/828151
Publication status	Published - 2011

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Chakera, A. H., Nielsen, B. S., Madsen, J., Romer, J., Kristjansen, P. E. G., Buch, I., Binderup, T., Ingvar, C., Nalla, A., Kjaer, A., Hesse, B., Chakera, A. H., Nielsen, B. S., Madsen, J., Rømer, J., Kristjansen, P. E. G., Buch, I., Binderup, T., Ingvar, C., ... Hesse, B. (2011). Immunolymphoscintigraphy for metastatic sentinel nodes: test of a model. International Journal of Molecular Imaging, 2011, 828151. https://doi.org/10.1155/2011/828151, https://doi.org/10.1155/2011/828151

Chakera, AH, Nielsen, BS, Madsen, J, Romer, J, Kristjansen, PEG, Buch, I, Binderup, T, Ingvar, C, Nalla, A, Kjaer, A, Hesse, B, Chakera, AH, Nielsen, BS, Madsen, J, Rømer, J, Kristjansen, PEG, Buch, I, Binderup, T, Ingvar, C, Nalla, A, Kjær, A & Hesse, B 2011, 'Immunolymphoscintigraphy for metastatic sentinel nodes: test of a model', International Journal of Molecular Imaging, vol. 2011, pp. 828151. https://doi.org/10.1155/2011/828151, https://doi.org/10.1155/2011/828151

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title = "Immunolymphoscintigraphy for metastatic sentinel nodes: test of a model",

abstract = "Aim. To develop a method and obtain proof-of-principle for immunolymphoscintigraphy for identification of metastatic sentinel nodes. Methods. We selected one of four tumour-specific antibodies against human breast cancer and investigated (1), in immune-deficient (nude) mice with xenograft human breast cancer expressing the antigen if specific binding of the intratumorally injected, radioactively labelled, monoclonal antibody could be scintigraphically visualized, and (2) transportation to and retention in regional lymph nodes of the radioactively labelled antibody after subcutaneous injection in healthy rabbits. Results and Conclusion. Our paper suggests the theoretical possibility of a model of dual isotope immuno-lymphoscintigraphy for noninvasive, preoperative, malignant sentinel node imaging.",

author = "Chakera, {A H} and Nielsen, {B S} and J Madsen and J Romer and Kristjansen, {P E G} and I Buch and Tina Binderup and C Ingvar and A Nalla and A Kjaer and B Hesse and Chakera, {A H} and Nielsen, {Boye S.} and J Madsen and John R{\o}mer and Kristjansen, {Paul Ejnar Gremaud} and I Buch and T Binderup and C Ingvar and Amarnadh Nalla and Andreas Kj{\ae}r and B Hesse",

year = "2011",

doi = "10.1155/2011/828151",

language = "English",

volume = "2011",

pages = "828151",

journal = "International Journal of Molecular Imaging",

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TY - JOUR

T1 - Immunolymphoscintigraphy for metastatic sentinel nodes: test of a model

AU - Chakera, A H

AU - Nielsen, B S

AU - Madsen, J

AU - Romer, J

AU - Kristjansen, P E G

AU - Buch, I

AU - Binderup, Tina

AU - Ingvar, C

AU - Nalla, A

AU - Kjaer, A

AU - Hesse, B

AU - Chakera, A H

AU - Nielsen, Boye S.

AU - Madsen, J

AU - Rømer, John

AU - Kristjansen, Paul Ejnar Gremaud

AU - Buch, I

AU - Binderup, T

AU - Ingvar, C

AU - Nalla, Amarnadh

AU - Kjær, Andreas

AU - Hesse, B

PY - 2011

Y1 - 2011

N2 - Aim. To develop a method and obtain proof-of-principle for immunolymphoscintigraphy for identification of metastatic sentinel nodes. Methods. We selected one of four tumour-specific antibodies against human breast cancer and investigated (1), in immune-deficient (nude) mice with xenograft human breast cancer expressing the antigen if specific binding of the intratumorally injected, radioactively labelled, monoclonal antibody could be scintigraphically visualized, and (2) transportation to and retention in regional lymph nodes of the radioactively labelled antibody after subcutaneous injection in healthy rabbits. Results and Conclusion. Our paper suggests the theoretical possibility of a model of dual isotope immuno-lymphoscintigraphy for noninvasive, preoperative, malignant sentinel node imaging.

AB - Aim. To develop a method and obtain proof-of-principle for immunolymphoscintigraphy for identification of metastatic sentinel nodes. Methods. We selected one of four tumour-specific antibodies against human breast cancer and investigated (1), in immune-deficient (nude) mice with xenograft human breast cancer expressing the antigen if specific binding of the intratumorally injected, radioactively labelled, monoclonal antibody could be scintigraphically visualized, and (2) transportation to and retention in regional lymph nodes of the radioactively labelled antibody after subcutaneous injection in healthy rabbits. Results and Conclusion. Our paper suggests the theoretical possibility of a model of dual isotope immuno-lymphoscintigraphy for noninvasive, preoperative, malignant sentinel node imaging.

U2 - 10.1155/2011/828151

DO - 10.1155/2011/828151

M3 - Journal article

SN - 2090-1712

VL - 2011

SP - 828151

JO - International Journal of Molecular Imaging

JF - International Journal of Molecular Imaging

ER -

Immunolymphoscintigraphy for metastatic sentinel nodes: test of a model

Abstract

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