ImmunoGrid, an integrative environment for large-scale simulation of the immune system for vaccine discovery, design and optimization

Francesco Pappalardo; Mark D Halling-Brown; Nicolas Rapin; Ping Zhang; Davide Alemani; Andrew Emerson; Paola Paci; Laurent Patrice Duroux; Marzio Pennisi; Arianna Palladini; Olivo Miotto; Daniel Churchill; Elda Rossi; Adrian J Shepherd; David S Moss; Filippo Castiglione; Massimo Bernaschi; Marie-Paule Lefranc; Søren Brunak; Santo Motta; Pier-Luigi Lollini; Kaye E Basford; Vladimir Brusic

doi:10.1093/bib/bbp014

ImmunoGrid, an integrative environment for large-scale simulation of the immune system for vaccine discovery, design and optimization

Francesco Pappalardo, Mark D Halling-Brown, Nicolas Rapin, Ping Zhang, Davide Alemani, Andrew Emerson, Paola Paci, Laurent Patrice Duroux, Marzio Pennisi, Arianna Palladini, Olivo Miotto, Daniel Churchill, Elda Rossi, Adrian J Shepherd, David S Moss, Filippo Castiglione, Massimo Bernaschi, Marie-Paule Lefranc, Søren Brunak, Santo MottaPier-Luigi Lollini, Kaye E Basford, Vladimir Brusic

35 Citations (Scopus)

Abstract

Vaccine research is a combinatorial science requiring computational analysis of vaccine components, formulations and optimization. We have developed a framework that combines computational tools for the study of immune function and vaccine development. This framework, named ImmunoGrid combines conceptual models of the immune system, models of antigen processing and presentation, system-level models of the immune system, Grid computing, and database technology to facilitate discovery, formulation and optimization of vaccines. ImmunoGrid modules share common conceptual models and ontologies. The ImmunoGrid portal offers access to educational simulators where previously defined cases can be displayed, and to research simulators that allow the development of new, or tuning of existing, computational models. The portal is accessible at .

Original language	English
Journal	Briefings in Bioinformatics
Volume	10
Issue number	3
Pages (from-to)	330-40
Number of pages	11
ISSN	1467-5463
DOIs	https://doi.org/10.1093/bib/bbp014
Publication status	Published - 2009

Keywords

Computational Biology
Computer Systems
Database Management Systems
Databases, Factual
Drug Design
Humans
Immune System
Major Histocompatibility Complex
Models, Biological
Systems Integration
Vaccines

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/bib/bbp014

Cite this

Pappalardo, F., Halling-Brown, M. D., Rapin, N., Zhang, P., Alemani, D., Emerson, A., Paci, P., Duroux, L. P., Pennisi, M., Palladini, A., Miotto, O., Churchill, D., Rossi, E., Shepherd, A. J., Moss, D. S., Castiglione, F., Bernaschi, M., Lefranc, M-P., Brunak, S., ... Brusic, V. (2009). ImmunoGrid, an integrative environment for large-scale simulation of the immune system for vaccine discovery, design and optimization. Briefings in Bioinformatics, 10(3), 330-40. https://doi.org/10.1093/bib/bbp014

Pappalardo, F, Halling-Brown, MD, Rapin, N, Zhang, P, Alemani, D, Emerson, A, Paci, P, Duroux, LP, Pennisi, M, Palladini, A, Miotto, O, Churchill, D, Rossi, E, Shepherd, AJ, Moss, DS, Castiglione, F, Bernaschi, M, Lefranc, M-P, Brunak, S, Motta, S, Lollini, P-L, Basford, KE & Brusic, V 2009, 'ImmunoGrid, an integrative environment for large-scale simulation of the immune system for vaccine discovery, design and optimization', Briefings in Bioinformatics, vol. 10, no. 3, pp. 330-40. https://doi.org/10.1093/bib/bbp014

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abstract = "Vaccine research is a combinatorial science requiring computational analysis of vaccine components, formulations and optimization. We have developed a framework that combines computational tools for the study of immune function and vaccine development. This framework, named ImmunoGrid combines conceptual models of the immune system, models of antigen processing and presentation, system-level models of the immune system, Grid computing, and database technology to facilitate discovery, formulation and optimization of vaccines. ImmunoGrid modules share common conceptual models and ontologies. The ImmunoGrid portal offers access to educational simulators where previously defined cases can be displayed, and to research simulators that allow the development of new, or tuning of existing, computational models. The portal is accessible at .",

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AU - Pappalardo, Francesco

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AU - Alemani, Davide

AU - Emerson, Andrew

AU - Paci, Paola

AU - Duroux, Laurent Patrice

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AU - Miotto, Olivo

AU - Churchill, Daniel

AU - Rossi, Elda

AU - Shepherd, Adrian J

AU - Moss, David S

AU - Castiglione, Filippo

AU - Bernaschi, Massimo

AU - Lefranc, Marie-Paule

AU - Brunak, Søren

AU - Motta, Santo

AU - Lollini, Pier-Luigi

AU - Basford, Kaye E

AU - Brusic, Vladimir

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ImmunoGrid, an integrative environment for large-scale simulation of the immune system for vaccine discovery, design and optimization

Abstract

Keywords

UN SDGs

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