Huth, C., Heid, I. M., Vollmert, C., Gieger, C., Grallert, H., Wolford, J. K., Langer, B., Thorand, B., Klopp, N., Hamid, Y. H., Pedersen, O., Hansen, T., Lyssenko, V., Groop, L., Meisinger, C., Döring, A., Löwel, H., Lieb, W., Hengstenberg, C., ... Illig, T. (2006). IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies. Diabetes, 55(10), 2915-21. https://doi.org/10.2337/db06-0600
Huth, C, Heid, IM, Vollmert, C, Gieger, C, Grallert, H, Wolford, JK, Langer, B, Thorand, B, Klopp, N, Hamid, YH, Pedersen, O, Hansen, T, Lyssenko, V, Groop, L, Meisinger, C, Döring, A, Löwel, H, Lieb, W, Hengstenberg, C, Rathmann, W, Martin, S, Stephens, JW, Ireland, H, Mather, H, Miller, GJ, Stringham, HM, Boehnke, M, Tuomilehto, J, Boeing, H, Möhlig, M, Spranger, J, Pfeiffer, A, Wernstedt, I, Niklason, A, López-Bermejo, A, Fernández-Real, J-M, Hanson, RL, Gallart, L, Vendrell, J, Tsiavou, A, Hatziagelaki, E, Humphries, SE, Wichmann, H-E, Herder, C & Illig, T 2006, 'IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies', Diabetes, vol. 55, no. 10, pp. 2915-21. https://doi.org/10.2337/db06-0600
@article{e8ee7ff9f47d4fb1ae3818ce0e80c607,
title = "IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies",
abstract = "Several lines of evidence indicate a causal role of the cytokine interleukin (IL)-6 in the development of type 2 diabetes in humans. Two common polymorphisms in the promoter of the IL-6 encoding gene IL6, -174G>C (rs1800795) and -573G>C (rs1800796), have been investigated for association with type 2 diabetes in numerous studies but with results that have been largely equivocal. To clarify the relationship between the two IL6 variants and type 2 diabetes, we analyzed individual data on >20,000 participants from 21 published and unpublished studies. Collected data represent eight different countries, making this the largest association analysis for type 2 diabetes reported to date. The GC and CC genotypes of IL6 -174G>C were associated with a decreased risk of type 2 diabetes (odds ratio 0.91, P = 0.037), corresponding to a risk modification of nearly 9%. No evidence for association was found between IL6 -573G>C and type 2 diabetes. The observed association of the IL6 -174 C-allele with a reduced risk of type 2 diabetes provides further evidence for the hypothesis that immune mediators are causally related to type 2 diabetes; however, because the association is borderline significant, additional data are still needed to confirm this finding.",
keywords = "Case-Control Studies, Diabetes Mellitus, Type 2, Genetics, Population, Humans, Interleukin-6, Odds Ratio, Polymorphism, Genetic, Promoter Regions, Genetic, Risk",
author = "Cornelia Huth and Heid, {Iris M} and Caren Vollmert and Christian Gieger and Harald Grallert and Wolford, {Johanna K} and Birgit Langer and Barbara Thorand and Norman Klopp and Hamid, {Yasmin H} and Oluf Pedersen and Torben Hansen and Valeriya Lyssenko and Leif Groop and Christa Meisinger and Angela D{\"o}ring and Hannelore L{\"o}wel and Wolfgang Lieb and Christian Hengstenberg and Wolfgang Rathmann and Stephan Martin and Stephens, {Jeffrey W} and Helen Ireland and Hugh Mather and Miller, {George J} and Stringham, {Heather M} and Michael Boehnke and Jaakko Tuomilehto and Heiner Boeing and Matthias M{\"o}hlig and Joachim Spranger and Andreas Pfeiffer and Ingrid Wernstedt and Anders Niklason and Abel L{\'o}pez-Bermejo and Jos{\'e}-Manuel Fern{\'a}ndez-Real and Hanson, {Robert L} and Luis Gallart and Joan Vendrell and Anastasia Tsiavou and Erifili Hatziagelaki and Humphries, {Steve E} and H-Erich Wichmann and Christian Herder and Thomas Illig",
year = "2006",
doi = "10.2337/db06-0600",
language = "English",
volume = "55",
pages = "2915--21",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association",
number = "10",
}
TY - JOUR
T1 - IL6 gene promoter polymorphisms and type 2 diabetes
T2 - joint analysis of individual participants' data from 21 studies
AU - Huth, Cornelia
AU - Heid, Iris M
AU - Vollmert, Caren
AU - Gieger, Christian
AU - Grallert, Harald
AU - Wolford, Johanna K
AU - Langer, Birgit
AU - Thorand, Barbara
AU - Klopp, Norman
AU - Hamid, Yasmin H
AU - Pedersen, Oluf
AU - Hansen, Torben
AU - Lyssenko, Valeriya
AU - Groop, Leif
AU - Meisinger, Christa
AU - Döring, Angela
AU - Löwel, Hannelore
AU - Lieb, Wolfgang
AU - Hengstenberg, Christian
AU - Rathmann, Wolfgang
AU - Martin, Stephan
AU - Stephens, Jeffrey W
AU - Ireland, Helen
AU - Mather, Hugh
AU - Miller, George J
AU - Stringham, Heather M
AU - Boehnke, Michael
AU - Tuomilehto, Jaakko
AU - Boeing, Heiner
AU - Möhlig, Matthias
AU - Spranger, Joachim
AU - Pfeiffer, Andreas
AU - Wernstedt, Ingrid
AU - Niklason, Anders
AU - López-Bermejo, Abel
AU - Fernández-Real, José-Manuel
AU - Hanson, Robert L
AU - Gallart, Luis
AU - Vendrell, Joan
AU - Tsiavou, Anastasia
AU - Hatziagelaki, Erifili
AU - Humphries, Steve E
AU - Wichmann, H-Erich
AU - Herder, Christian
AU - Illig, Thomas
PY - 2006
Y1 - 2006
N2 - Several lines of evidence indicate a causal role of the cytokine interleukin (IL)-6 in the development of type 2 diabetes in humans. Two common polymorphisms in the promoter of the IL-6 encoding gene IL6, -174G>C (rs1800795) and -573G>C (rs1800796), have been investigated for association with type 2 diabetes in numerous studies but with results that have been largely equivocal. To clarify the relationship between the two IL6 variants and type 2 diabetes, we analyzed individual data on >20,000 participants from 21 published and unpublished studies. Collected data represent eight different countries, making this the largest association analysis for type 2 diabetes reported to date. The GC and CC genotypes of IL6 -174G>C were associated with a decreased risk of type 2 diabetes (odds ratio 0.91, P = 0.037), corresponding to a risk modification of nearly 9%. No evidence for association was found between IL6 -573G>C and type 2 diabetes. The observed association of the IL6 -174 C-allele with a reduced risk of type 2 diabetes provides further evidence for the hypothesis that immune mediators are causally related to type 2 diabetes; however, because the association is borderline significant, additional data are still needed to confirm this finding.
AB - Several lines of evidence indicate a causal role of the cytokine interleukin (IL)-6 in the development of type 2 diabetes in humans. Two common polymorphisms in the promoter of the IL-6 encoding gene IL6, -174G>C (rs1800795) and -573G>C (rs1800796), have been investigated for association with type 2 diabetes in numerous studies but with results that have been largely equivocal. To clarify the relationship between the two IL6 variants and type 2 diabetes, we analyzed individual data on >20,000 participants from 21 published and unpublished studies. Collected data represent eight different countries, making this the largest association analysis for type 2 diabetes reported to date. The GC and CC genotypes of IL6 -174G>C were associated with a decreased risk of type 2 diabetes (odds ratio 0.91, P = 0.037), corresponding to a risk modification of nearly 9%. No evidence for association was found between IL6 -573G>C and type 2 diabetes. The observed association of the IL6 -174 C-allele with a reduced risk of type 2 diabetes provides further evidence for the hypothesis that immune mediators are causally related to type 2 diabetes; however, because the association is borderline significant, additional data are still needed to confirm this finding.
KW - Case-Control Studies
KW - Diabetes Mellitus, Type 2
KW - Genetics, Population
KW - Humans
KW - Interleukin-6
KW - Odds Ratio
KW - Polymorphism, Genetic
KW - Promoter Regions, Genetic
KW - Risk
U2 - 10.2337/db06-0600
DO - 10.2337/db06-0600
M3 - Journal article
C2 - 17003362
SN - 0012-1797
VL - 55
SP - 2915
EP - 2921
JO - Diabetes
JF - Diabetes
IS - 10
ER -
