IL-6, but not TNF-α, increases plasma YKL-40 in human subjects

Anders R Nielsen; Peter Plomgaard; Karen S Krabbe; Julia S Johansen; Bente K Pedersen

doi:10.1016/j.cyto.2011.03.014

IL-6, but not TNF-α, increases plasma YKL-40 in human subjects

Anders R Nielsen, Peter Plomgaard, Karen S Krabbe, Julia S Johansen, Bente K Pedersen

64 Citations (Scopus)

Abstract

Plasma levels of YKL-40 are elevated in patients with systemic infection, inflammatory disorders and cancer. Both monocytes/macrophages, neutrophils, and cancer cells have the capacity to produce YKL-40, but the regulation during the inflammatory response is unknown. To study the possible role of interleukin-6 (IL-6) and tumor necrosis factor (TNF)-α in the regulation of YKL-40 plasma levels, we included healthy men, who received either recombinant human (rh)IL-6 (n=6), rhTNF-α (n=8) or vehicle (n=7) for 3. h. The plasma levels of IL-6 and TNF-α reached ~150 and ~18. pg/ml, respectively, during the infusions. Following the IL-6 infusion, the plasma level of YKL-40 increased from ~30 to ~57. ng/ml (p<0.05) at 24. h, and returned to normal values after 48. h. The plasma level of YKL-40 did not change during TNF-α infusion or infusion of vehicle. These data demonstrate that IL-6, but not TNF-α, has a key-role in the regulation of plasma YKL-40 levels during inflammation.

Original language	English
Journal	Cytokine
Volume	55
Issue number	1
Pages (from-to)	152-5
Number of pages	4
ISSN	1043-4666
DOIs	https://doi.org/10.1016/j.cyto.2011.03.014
Publication status	Published - Jul 2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.cyto.2011.03.014

Cite this

@article{ba2cbdabcc804205b1498ad45cc87ab9,

title = "IL-6, but not TNF-α, increases plasma YKL-40 in human subjects",

abstract = "Plasma levels of YKL-40 are elevated in patients with systemic infection, inflammatory disorders and cancer. Both monocytes/macrophages, neutrophils, and cancer cells have the capacity to produce YKL-40, but the regulation during the inflammatory response is unknown. To study the possible role of interleukin-6 (IL-6) and tumor necrosis factor (TNF)-α in the regulation of YKL-40 plasma levels, we included healthy men, who received either recombinant human (rh)IL-6 (n=6), rhTNF-α (n=8) or vehicle (n=7) for 3. h. The plasma levels of IL-6 and TNF-α reached ~150 and ~18. pg/ml, respectively, during the infusions. Following the IL-6 infusion, the plasma level of YKL-40 increased from ~30 to ~57. ng/ml (p<0.05) at 24. h, and returned to normal values after 48. h. The plasma level of YKL-40 did not change during TNF-α infusion or infusion of vehicle. These data demonstrate that IL-6, but not TNF-α, has a key-role in the regulation of plasma YKL-40 levels during inflammation.",

author = "Nielsen, {Anders R} and Peter Plomgaard and Krabbe, {Karen S} and Johansen, {Julia S} and Pedersen, {Bente K}",

year = "2011",

month = jul,

doi = "10.1016/j.cyto.2011.03.014",

language = "English",

volume = "55",

pages = "152--5",

journal = "Cytokine",

issn = "1043-4666",

publisher = "Academic Press",

number = "1",

}

TY - JOUR

T1 - IL-6, but not TNF-α, increases plasma YKL-40 in human subjects

AU - Nielsen, Anders R

AU - Plomgaard, Peter

AU - Krabbe, Karen S

AU - Johansen, Julia S

AU - Pedersen, Bente K

PY - 2011/7

Y1 - 2011/7

N2 - Plasma levels of YKL-40 are elevated in patients with systemic infection, inflammatory disorders and cancer. Both monocytes/macrophages, neutrophils, and cancer cells have the capacity to produce YKL-40, but the regulation during the inflammatory response is unknown. To study the possible role of interleukin-6 (IL-6) and tumor necrosis factor (TNF)-α in the regulation of YKL-40 plasma levels, we included healthy men, who received either recombinant human (rh)IL-6 (n=6), rhTNF-α (n=8) or vehicle (n=7) for 3. h. The plasma levels of IL-6 and TNF-α reached ~150 and ~18. pg/ml, respectively, during the infusions. Following the IL-6 infusion, the plasma level of YKL-40 increased from ~30 to ~57. ng/ml (p<0.05) at 24. h, and returned to normal values after 48. h. The plasma level of YKL-40 did not change during TNF-α infusion or infusion of vehicle. These data demonstrate that IL-6, but not TNF-α, has a key-role in the regulation of plasma YKL-40 levels during inflammation.

AB - Plasma levels of YKL-40 are elevated in patients with systemic infection, inflammatory disorders and cancer. Both monocytes/macrophages, neutrophils, and cancer cells have the capacity to produce YKL-40, but the regulation during the inflammatory response is unknown. To study the possible role of interleukin-6 (IL-6) and tumor necrosis factor (TNF)-α in the regulation of YKL-40 plasma levels, we included healthy men, who received either recombinant human (rh)IL-6 (n=6), rhTNF-α (n=8) or vehicle (n=7) for 3. h. The plasma levels of IL-6 and TNF-α reached ~150 and ~18. pg/ml, respectively, during the infusions. Following the IL-6 infusion, the plasma level of YKL-40 increased from ~30 to ~57. ng/ml (p<0.05) at 24. h, and returned to normal values after 48. h. The plasma level of YKL-40 did not change during TNF-α infusion or infusion of vehicle. These data demonstrate that IL-6, but not TNF-α, has a key-role in the regulation of plasma YKL-40 levels during inflammation.

U2 - 10.1016/j.cyto.2011.03.014

DO - 10.1016/j.cyto.2011.03.014

M3 - Journal article

SN - 1043-4666

VL - 55

SP - 152

EP - 155

JO - Cytokine

JF - Cytokine

IS - 1

ER -

IL-6, but not TNF-α, increases plasma YKL-40 in human subjects

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this