Abstract
Guanethidine sulphate 40 mg/kg intraperitoneally for 14 days induced chromatolysis and nerve cell death in the superior cervical ganglia of athymic nude (rnu/rnu) LEW/Mol rats and their euthymic (+/rnu) LEW/Mol heterozygous littermates. Histologically the sympathetic ganglia were dominated by an infiltration of small inflammatory cells. By means of monoclonal antibodies these cells were identified. The number of B-lymphocytes increased following guanethidine in both athymic and euthymic rats. The number of T-lymphocytes increased to a great extent in euthymic rats, but was virtually missing in athymic rats. The number of NK-cells and monocytes/macrophages increased in both athymic and euthymic rats. The conclusion is, that guanethidine exerts a direct effect on sympathetic ganglion cells followed by a thymus-independent immune response.
| Original language | English |
|---|---|
| Journal | International Journal of Immunopharmacology |
| Volume | 12 |
| Issue number | 3 |
| Pages (from-to) | 327-30 |
| Number of pages | 4 |
| ISSN | 0192-0561 |
| Publication status | Published - 1990 |
Keywords
- Animals
- Antibodies, Monoclonal
- B-Lymphocytes
- Body Weight
- Cell Count
- Ganglia, Sympathetic
- Guanethidine
- Immunoenzyme Techniques
- Killer Cells, Natural
- Leukocytes, Mononuclear
- Male
- Organ Size
- Rats
- Rats, Mutant Strains
- Rats, Nude
- Spleen
- Sympathectomy, Chemical