Identification of plant extracts with potential antidiabetic properties: effect on human peroxisome proliferator-activated receptor (PPAR), adipocyte differentiation and insulin-stimulated glucose uptake

Kathrine B Christensen; Ariane Minet; Henrik Svenstrup; Kai Grevsen; Hongbin Zhang; Eva Schrader; Gerald Rimbach; Silvia Wein; Siegfried Wolffram; Karsten Kristiansen; Lars P Christensen

doi:10.1002/ptr.2782

Identification of plant extracts with potential antidiabetic properties: effect on human peroxisome proliferator-activated receptor (PPAR), adipocyte differentiation and insulin-stimulated glucose uptake

Kathrine B Christensen, Ariane Minet, Henrik Svenstrup, Kai Grevsen, Hongbin Zhang, Eva Schrader, Gerald Rimbach, Silvia Wein, Siegfried Wolffram, Karsten Kristiansen, Lars P Christensen

Department of Biology

50 Citations (Scopus)

Abstract

Thiazolidinediones (TZDs) are insulin sensitizing drugs used to treat type 2 diabetes. The primary target of the TZDs is the peroxisome proliferator-activated receptor (PPAR) gamma, a key regulator of adipogenesis and glucose homeostasis. Currently prescribed TZDs are full PPARgamma agonists, and their use is associated with several side effects. Partial PPARgamma agonists appear to be associated with fewer side effects but may still confer the desired insulin sensitizing action. Extracts from common medicinal/food plants were tested in a screening platform comprising a series of bioassays, including tests for PPARgamma, alpha and delta transactivation, adipocyte differentiation and insulin-stimulated glucose uptake, allowing identification of plants containing potentially interesting PPAR agonists. Twenty-two plant extracts out of 133 were found to increase insulin-stimulated glucose uptake and 18 extracts were found to activate PPARgamma, 3 to activate PPARalpha and gamma, 6 to activate PPARdelta and gamma, and 9 to activate PPARgamma, alpha and delta. Among the 24 different plant species tested in the platform, 50% were shown to contain compounds capable of activating PPARgamma and stimulating insulin-dependent glucose uptake with no or little effect on adipocyte differentiation warranting further studies and characterization. Copyright (c) 2009 John Wiley & Sons, Ltd.

Original language	English
Journal	Phytotherapy Research
Volume	23
Issue number	9
Pages (from-to)	1316-1325
ISSN	0951-418X
DOIs	https://doi.org/10.1002/ptr.2782
Publication status	Published - 2009

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Christensen, K. B., Minet, A., Svenstrup, H., Grevsen, K., Zhang, H., Schrader, E., Rimbach, G., Wein, S., Wolffram, S., Kristiansen, K., & Christensen, L. P. (2009). Identification of plant extracts with potential antidiabetic properties: effect on human peroxisome proliferator-activated receptor (PPAR), adipocyte differentiation and insulin-stimulated glucose uptake. Phytotherapy Research, 23(9), 1316-1325. https://doi.org/10.1002/ptr.2782

Identification of plant extracts with potential antidiabetic properties: effect on human peroxisome proliferator-activated receptor (PPAR), adipocyte differentiation and insulin-stimulated glucose uptake. / Christensen, Kathrine B; Minet, Ariane; Svenstrup, Henrik et al.

In: Phytotherapy Research, Vol. 23, No. 9, 2009, p. 1316-1325.

Research output: Contribution to journal › Journal article › Research › peer-review

Christensen, KB, Minet, A, Svenstrup, H, Grevsen, K, Zhang, H, Schrader, E, Rimbach, G, Wein, S, Wolffram, S, Kristiansen, K & Christensen, LP 2009, 'Identification of plant extracts with potential antidiabetic properties: effect on human peroxisome proliferator-activated receptor (PPAR), adipocyte differentiation and insulin-stimulated glucose uptake', Phytotherapy Research, vol. 23, no. 9, pp. 1316-1325. https://doi.org/10.1002/ptr.2782

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title = "Identification of plant extracts with potential antidiabetic properties: effect on human peroxisome proliferator-activated receptor (PPAR), adipocyte differentiation and insulin-stimulated glucose uptake",

abstract = "Thiazolidinediones (TZDs) are insulin sensitizing drugs used to treat type 2 diabetes. The primary target of the TZDs is the peroxisome proliferator-activated receptor (PPAR) gamma, a key regulator of adipogenesis and glucose homeostasis. Currently prescribed TZDs are full PPARgamma agonists, and their use is associated with several side effects. Partial PPARgamma agonists appear to be associated with fewer side effects but may still confer the desired insulin sensitizing action. Extracts from common medicinal/food plants were tested in a screening platform comprising a series of bioassays, including tests for PPARgamma, alpha and delta transactivation, adipocyte differentiation and insulin-stimulated glucose uptake, allowing identification of plants containing potentially interesting PPAR agonists. Twenty-two plant extracts out of 133 were found to increase insulin-stimulated glucose uptake and 18 extracts were found to activate PPARgamma, 3 to activate PPARalpha and gamma, 6 to activate PPARdelta and gamma, and 9 to activate PPARgamma, alpha and delta. Among the 24 different plant species tested in the platform, 50% were shown to contain compounds capable of activating PPARgamma and stimulating insulin-dependent glucose uptake with no or little effect on adipocyte differentiation warranting further studies and characterization. Copyright (c) 2009 John Wiley & Sons, Ltd.",

author = "Christensen, {Kathrine B} and Ariane Minet and Henrik Svenstrup and Kai Grevsen and Hongbin Zhang and Eva Schrader and Gerald Rimbach and Silvia Wein and Siegfried Wolffram and Karsten Kristiansen and Christensen, {Lars P}",

note = "Keywords medicinal plants • food plants • type 2 diabetes • peroxisome proliferator-activated receptors (PPARs) • adipocyte differentiation • glucose uptake",

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AU - Christensen, Kathrine B

AU - Minet, Ariane

AU - Svenstrup, Henrik

AU - Grevsen, Kai

AU - Zhang, Hongbin

AU - Schrader, Eva

AU - Rimbach, Gerald

AU - Wein, Silvia

AU - Wolffram, Siegfried

AU - Kristiansen, Karsten

AU - Christensen, Lars P

N1 - Keywords medicinal plants • food plants • type 2 diabetes • peroxisome proliferator-activated receptors (PPARs) • adipocyte differentiation • glucose uptake

PY - 2009

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N2 - Thiazolidinediones (TZDs) are insulin sensitizing drugs used to treat type 2 diabetes. The primary target of the TZDs is the peroxisome proliferator-activated receptor (PPAR) gamma, a key regulator of adipogenesis and glucose homeostasis. Currently prescribed TZDs are full PPARgamma agonists, and their use is associated with several side effects. Partial PPARgamma agonists appear to be associated with fewer side effects but may still confer the desired insulin sensitizing action. Extracts from common medicinal/food plants were tested in a screening platform comprising a series of bioassays, including tests for PPARgamma, alpha and delta transactivation, adipocyte differentiation and insulin-stimulated glucose uptake, allowing identification of plants containing potentially interesting PPAR agonists. Twenty-two plant extracts out of 133 were found to increase insulin-stimulated glucose uptake and 18 extracts were found to activate PPARgamma, 3 to activate PPARalpha and gamma, 6 to activate PPARdelta and gamma, and 9 to activate PPARgamma, alpha and delta. Among the 24 different plant species tested in the platform, 50% were shown to contain compounds capable of activating PPARgamma and stimulating insulin-dependent glucose uptake with no or little effect on adipocyte differentiation warranting further studies and characterization. Copyright (c) 2009 John Wiley & Sons, Ltd.

AB - Thiazolidinediones (TZDs) are insulin sensitizing drugs used to treat type 2 diabetes. The primary target of the TZDs is the peroxisome proliferator-activated receptor (PPAR) gamma, a key regulator of adipogenesis and glucose homeostasis. Currently prescribed TZDs are full PPARgamma agonists, and their use is associated with several side effects. Partial PPARgamma agonists appear to be associated with fewer side effects but may still confer the desired insulin sensitizing action. Extracts from common medicinal/food plants were tested in a screening platform comprising a series of bioassays, including tests for PPARgamma, alpha and delta transactivation, adipocyte differentiation and insulin-stimulated glucose uptake, allowing identification of plants containing potentially interesting PPAR agonists. Twenty-two plant extracts out of 133 were found to increase insulin-stimulated glucose uptake and 18 extracts were found to activate PPARgamma, 3 to activate PPARalpha and gamma, 6 to activate PPARdelta and gamma, and 9 to activate PPARgamma, alpha and delta. Among the 24 different plant species tested in the platform, 50% were shown to contain compounds capable of activating PPARgamma and stimulating insulin-dependent glucose uptake with no or little effect on adipocyte differentiation warranting further studies and characterization. Copyright (c) 2009 John Wiley & Sons, Ltd.

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DO - 10.1002/ptr.2782

M3 - Journal article

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SN - 0951-418X

VL - 23

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JO - Phytotherapy Research

JF - Phytotherapy Research

IS - 9

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Identification of plant extracts with potential antidiabetic properties: effect on human peroxisome proliferator-activated receptor (PPAR), adipocyte differentiation and insulin-stimulated glucose uptake

Abstract

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